The distribution and temporal course of fiber degeneration after heidecortication in the albino rat

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NAME AND ADDRESS

DATE

E0RTM1SKS i’lvEii m u v m z i n

m s

msmxwmxm

m m m

&m m m m & z

qobhsb of

m m i m & r i m a t o h stBasacoBTxcAno*

X* TUB

kt&im BAT

a mmmsh'tim r a i s m

xi im

to tbs m u s m m m m m ,

m m m w x u m m ot tbb kbqox8b«sb» for fcfc* faeaiau lu a

le n ti© u te ri# *

fiee* (*4§) supported the above v i m » whim he noted teat

area 4 projected in to tte p u t* * * * an# the ©end* te

mnd, ptttaaen

eend th e ir fib e r * mainly into tee pallidum* O w material tee e©» firmed e eertieal connection to tte striatum*

i* tee# noted teat tte teterife*© tester pteav# of

tele ©truetwo Xoeea many fine Jteere after ©orfcl cal ablation* We teve likewise noted little evidence for striatal oomec%£*&* eat*!#* tee pallltesi*

Eeeewer, our meter lei wee m t

suited for ferreting out atrtetettetemle or itetaM-strait* reletieteMpe*

He tewo reported « significant increase- In

tee fiber tegeeeretiom of tee pallid.m after striatal injury. Ite connection® of tee pall 1 d m are m m f an# somewhat ©ompteau

lam son* Earnest and leasst* {*41) after lesion# te

tte ptei t e ® in tee monkey m m

to tee following conclusion#,

teey fteMl teat tee pallldaa gave rite to neat if «et « H of

tee fiber* of tte ana# and faaelm&as teatlealarl#*

they

note# teat tte vest majority of tteae fiber* run ©aiateXward

a# far aa tee m field of Forel* teen t a n d©r*ally ate let©rally in tte faealMla* tealaadatta to end in tte nucleus vaatraXI* anterior of tee teateras*

ffcioe# investigator#

etato teat# *i» a w Martel material# *#ifc become# ©tear

th a t tte

num ber o f n .fe r a w h it e re a c h th e t h a l e I n

way la w r y Xar^#-***

th is

teay also reported that te© pallidum

p W - rl$# to fiber©

to tee eu1 totec&mX# nuoleua and

hypeteeXaaawa * ftef Xlkowta# t e w found large n t e b w e of fi­ bers aeoetein^ f&&&. the mbefcimtla nigra to tea pallidum# Bod tea {*40} tea reported ©triato-teax&ml#, atriaietaewtaX* atrteto-ambteelaial# sad ateteteteg»-atal ©osmeat i m e In tte

aerebtaeff {f40) studying tea lama-

etriate e#m#@tlsme has m # M » i

teats

tea fibre# teaXeswairleee m t eminent dan# 1# noyau m w &4 at tea* la p u t m m m at M l t a a a t da trola ooyeoa

ttete®&wa#*« ^ t?n ##ntln$«^t pern emeitereble eat l a m du noyau euatwa-l mfcerm#, etahXleaa&t mn« conned on afferent# itelreet* eatre l feoo«# elmguXair# antorieure at la atrie turn* $m eeatiagaat pin# eeaelteretole xe*t lean 4m aejram ventral later®#| c# aeyim *«t rail#* iteatre pert, a l*ee*ree frontal# ajpemaatr# in ttefc te he® ale# oteervai e eenalterabl# e#n~ nettle a be tween the £;*aXi*ta end tte teeluue# noted direct f i b w e in an w n l

Shi# author

amponant to the ventral an­

terior u m l m M and via tee feeeietslwe X#afciwXarl*-te#ei*alu* ttelteleme t# tte lateral tealaaie nmolene*

Be Xiteewiea noted

fiber* t m m tte pallltett to tee fcypotheisms* and eomeXteed teat r n m m i# a alaaa iiterwtetimifeip between tte atrlopill 1 d m , tee fealaxM

hfpotmimmum*

0*mJ> ate leauXXoeh (*te) f e m l direfct eortioe-pallliml

66*

from « m

# -actd-po**!*!? 4 a&d 4*

lo s * tn d . WeaJUty ( f 4&) a f t e r an latandad ab latio n o f tte a w t a * m & stria in® i» three rahfeite .aaaolndad that all tor#aX tteliitle nnc-Xai iteln^tng thoae of tte ^iidxs.na tastderaaiit

nail d#it*teiNkhian« *$wo of tteee aalsaXa 'aurvlvsd .ifc.dtoya aad-cma If-*

Thm& -fmm rapwftad

m 4 l f t nmmm in tte

4agr^@ of dtoganaaaation tetvaaa the a# tvo- -anrviva! tisaejs* With ten antes! a tevipg only aav ta*.'aattrjpatad* tteaa author* eonetoda that .iter* •■■:****■ . 011X7 a f**r aXaiaamt* ah.Xeh oan eo&aaiv^ algly Aapactd upon atelattm or amyttoXs *

afta*Aa*f*» oanttw ■wdia&m*

fte-ea n m tte pnmfmm**

ml%tz it# m m l m w n t

ajratMi* lntarw 4 i0 4 »taXia and tte rtemteldali** -It «a& te -aafead that in ftftff eata vtev* tter* w&# a stated raiaevaX. of tte w r t e a ate striate* tear a w*e liteviaa injury from sllgte

4a aateaaiva to tte fallxdto*

ftea# authors* teliavta$ tte

f a l l 14m to h# a p art o f t t e hfpotteXamu# te v * dieragardad this iwoXvmaaht of tte paXXiitm In aaaft ®&*#«

Xterafore*

tteir £i**di»$ that tte ssidXina auolat art involved eenid ?«ty

♦daily te to* te tte Xntelvamnt of tte pall 1d m vfoleh la note ■naated via tte Inferior tteX&mlo patoncX* to tte nmtni of tte aid! tea ratter tten being too to injury to tte earte* or atria** turn a a ttiay tellavad* In 4 M a atuiy it.hat t e m eo&atatabtly -Betad that «uftar

and' temitoeorti e&Mon pin a hmlatrlateotowgr a Xar§a

prmpmtlm of tte ttelamla radiation* persist* ftera

1# a fiatetitetiv* Xes« of fiters tet from the qualitative standpoint the teste radiatlsfiaX pattern is aaintaiaed*

ftesw fiters* per41 eul

the a* t® tte anterior nuclei, are

not fte&g*# simply dy astetetng tte poateparativ© survival |time#

Hatter* tte fiber pattern at 144 days seams more ia-

tensive &®m to tte atrophy ate loss of cellular elements of tee thalamus* eloaelf $*ated«

tte spaces in between tee fibers are teen more After tte dleappMranea of cortical fibers,

it can be seen teat moat of tte®* remaining fascicles are In­ terrelating tee ttelimie ate pallidum*

these bundles can be

teased tteeagh tee degenerate# capsule Into tte rentes lie wanteeXa tore lie wtere teey appear to congregate * Otter fiber# no*# Into the medial {port of the capsule* run eaudally fop 8o;:..e distance on# than contribute many fltort to the onoo

lentiaularl* on# seme to the inferior thalamic peduncle. That theaa remaining fibers or* related to the pallidum to further

•widen®## by th* dot* obtain*# from th# too animal® with dl» root loot on* to th* pell law®.

In these brains, which *#r#

stained with silver, It wee no tad that the thalamic radio tlono war# quit# filled with degenerated fibers, where# s> after hemldecertication or atrlateatonf there o w e always more nornol than detenunoting fibers,

in one ease where only the medial

ed.;e of the pallidum was intact, fibers could be traced fro® this portion eou dally into the medial pari of the capsule and from there into the hypothalamus and medial thalamus. On the other hand the remaining radiations were filled with degenerating fibers.

In thne earn# two brain# degenerating

fibers were traced into the subthalamic nucleus of buys, the aon* iacerte and th* substantia nigra*

The nigral degenera-

fcioa mm mmb mor* tern test m m w ith ©arti©*! mw&mX aim*. In tea®* mmm to* brmltxm 4*gm#r*tl*n was note# in th* rteoW t W l i i tarateteaXi® ate anterior milaXi®#

tea 4*g*tt*r*tion

in tel* last atrnotmr* 1* only Mao»u*X in that 14 appaar* 5 day* *teU*JP’ttea with ©wtteal a&utten*

te* • x m r l m n t

mhmmtn th* tsailitl part of te® fNtiUMm was intact shewed tea*'4##NMii*UM in th*** mlilln* mate! tern #14 tte

&m

tear® *11 ©I tte pmXll$mm was #jEt&r**t*&«

in maw to* Mtehl- ate#!*®1 with i M t e U i t e t e r *up**~ lap©**# m m f mute® pw*vian* teteiaoortleation nr® tev* foam# ramlte ©*n*l©t*nt with tte#®- of tte allvar prop® ration®# laving f w n # teat tte teraiil gyanvl#® m

longer stain altar

§ a n t i t m ©an ©©mini* teat tea gr*at**t part ©I tte' $***«► nlmm ©te*nr*4 war* of etrio pallidal origin*

teg*n*r*tiag

ayalln *a® »tete®4 in all ter** antar lor nuclei ate to* tearl**t in tte anterior nt*Atelft*»

toamil** war® -tr***4 into tte

parataGialie, m*41*11 ®# mteedin®* vantralia a*41*li*> p*ra~ *** {*4?} tea m t e

tea Interesting ©te*rv*tlon that ©*a~

£ l m m a finding of Stetlar (a* ©noted hy

teat osaiopftll-

1© granni*® ©t o often te ®*®n in ahromtelytl© nerv® ©*11®*

fte* author m g $ * * t * this a® a y©**lbte now m t t e # ©I iiantitying I n t e r c o m * a t ion* within te® ©toteal n® ****** »y«t*iu

w*

Haw* ©teanrai tel* phenomenon ©maiataiitly in our experimental lw©M

preparation®#

lotaw*

it always ******* ©a tete *14**

In tea m a a a tear® w ® ter* ©tear*®# it*

w® 4® not tell*** that

tte* 1* a m l tabla procodtir*, since than* tev# teen **®n In **11® *f m l » l

©n tte a o m a l alia*

69.

feeeiewleri©, rto#b©16ftli©» ventral!©

ventral*

In wentra&ftterelie*. raraveterltolerie pmrrn rotundoeellulert®, mtornmlmmlm w m X m m m ©te tte Mtetanti* nigra* ■ Hone ©mild to feute in tte m m

invent**

toehte# the m

fitera m m mi

er ©trial®! origin

le Sj^eeeihl# to m m r t m l n glreefcx? *

However* fra# w

MieFlal we tew© m t # 6 that ©irlrattela$d©

other

mmmmtolmm era

not a* © M teewf * where©** thee# interaenneetlng the ttelesm©

mm& pmMMum

mm

mnmh mmm mxtommmtwo* ften* It ©oaaa fair

to esmolte© ttet tte ©tew© mmmlrnt m m tte fNt&lMiin*

ran-raoied pratehly to

If toi© he $e* then it fell owe the! mmlf the

rami###* tatora&l**. ©te teuton let# to6l*» 6© not receive iton ew give off titrate fttera to toe p#lll6w«

thee# fine*

luge era ©eneeMnt with tte phretetoglee! tnterprateii©**© era* eemied ra ©enttf e # M # m i # g tte interr©la11on©hi p« of tte ©ora teat# etrie%wa&f palMdnm* teatem© m m

porter*

tte ©teene© of Her ©hi Regeneration in tte ineert© tout presence in ©liver eerie© of Regeneration of toe fttera in­ tit©#to© ttet tte©# era pmtomtolj llgMiar w$felinetoR or nmayeMnetoi fitera. 6.

ieneraX Oeaelti©ration#

Hi to tte# etotir we here teen ©hi© to mmll&m tte eigniflcent eRventogee of m t e i e c toe ratr© grade cell ^generation* get*tot* #te tieJftX properetione.

Ieoh to-otai### give® e differ­

ent pi©tore or mmpmmto of the m m pr&hXmm* taraleti#© wrabtottobl# wito the ©there*

tech contribute# with retrograde cell

ehenge# era le ehle to 6#t©raUft# toeleiaoeorti cel connection©.

VM IpMrablsn*

abate first a platers of bha m^raXin$t#a fibsr te~ It- to ■partismlarXf teaateagaaaa sloea tea Sagan*

arat%®m it ssaa on an wsfcaiiiaii of ©Xaar be ©kgroote, teus aaabltef ® m to mm salts rapMlf tea ilrastiot* o f passaga ©f tea lajorte flbara*

Wlte th* £*jal sllrsr stain 0 1 it

Alii to s#$ tfatalls thick © mm® % ba #aaas$ from the abort pMatewsau

first of all* both w$oltnm%o& nut an^alinattti

fibars tan ba tt#n

tear art tegaasraMng*

arablng flbars m m m m m m

m

ftesa Sagan-

of norm! fibs**)

stesa both Sagan « a ting an* norml fibara art sfcal&*4«

Urns

ana it tbit to gtbamXna ratter praaiaslgr white flter grasp# art affa#ta$ by tea laalatt* an# w M t e m m ln normal.

tbit

faster mw&m- tea amlraia o f bteat pwmpmmtkonm mate m m tlma mm^mtn^ than it tea ate% ®f tea Martels.

Howars? 9

tea astww t$ m iavslwad it » p t M by tea a«#rs inferastlaftSMaiauMU

ftesa m U X m m prtpinbiont art tit© awlbad it not*

lag tea dropping ott of ft bar* a te ** atari? all tea fiber# art stain#*• It steal# ta- palate# oat that tea OajsX s ta in a ttt; h a rt s ta in * p rta a rtl? « *•» * * i t a o a lj t faw dsnarite# lasitea#*

BMW***, om m m flat Oajal states aoltebla for

i m « » SsnSrtta* or toll States*

Ste ailvar stain* feart a

at m i t t tawantag* orsr otter baste!****® in teat ana eaa

a m t U y tetas»te* tea glffaransa bafcwaa** trawMtla ate tens iiUcvlci ds^pmstetlsn*

It is t e U s w d teat tea larshi ate

Csjal te s ta te * * * a r t parbttalarlr state* to btiag naa# to * gates* to atippXawanb sate otter in a afcteg susb as tea ona

pratamte# tiara*

TU

Vim m tom M t o m t w m mmm&Mm tom t l t o i ®mmmm%imm t o * t m m % tom m t o t o A w t a j s * m m l m m

mmUrn m m

Wmm m m

wmlum*

U>

mm

tta&mM*

fftra*

m m m m m t t m ® mf

tea wmptofamto# A to m tt) tom %-mmmt mmwm «f to$mnmm~ ttog f l M r * An* if) m m m m t o m m mi m ®

tn

to' ®%m€t t o m m 'to m m

4# t o t o m wmtm tom t o m -

£lm$* tfp M # t

{ ! ) - tw adfatoiftiM tlesi*

m to jm to to t o

it|

«nfl

m % tom

m i

teay

Cf) U m m M m m tt * m i C4) i» « t * t i* io ^ x it ia a *

#44# m . &

to to to m * % im to & m % *

p m m 4 % M w m & state* 1 m m tom. nmto* nte,

isfsl ami lirifei *

m toMto** tf OH?*

ttasa# uti^ tt»is~

in -m&m is fsiastofcta* tom tta#

flfr#*S &ik#wit# a mmmliatlm. mm bam wmm batmaam th# 1m® of ■■mmUmm $ m m m

boon

sad a m b l m ^ b h a l M M a osiuttotis&s*

t t m m hovo

with Mtwsgwodo m i l ovldottoo# of thalam*amwtl*

m l ositMStlsM* aXmm of tbm

ttok m o i m * haw baan Sise#***# with # w m XI tow# tw o *

1# $**## m p m t m r n ih# p m m i a f e m M * of isaop ttbawa In bha

tabtan wfcl#h mt&mnam hma ladle&toi ##* pnlli** 4ml tm aamrnmHaWf E^wSjatotol i«mw#& of tto otptstmi Mss tto&Ml* m 4

to&to fam £ % b m a t m m f M a i t w l m i t H f i m set tto&s paint 1# m b p m l X M m st9M§

to i&o W m l m m m *

almrnw « & *

Aft#** loatam to tfe*

m w m m m t t m m bmva b a m #fe##nr#d*

fhasa

hsiro M a n oowoiistod with sfcyrsta&M^ssl tod « m i w i l M l roporta of .sthar l&vMttgsto##*

>*ttld#Mitsais«6 § toforMtioo*

fhoy

Hut Mm s M

stain# of I w i M &omiotrio«*

mmbfa* mibm aertlosl m m m l jmv’s baa® w r y shorn that isoot #f th# fc&sloisio iraeXol

h o w sfcplogMOltfsul m m m w M w # #

this has *•#» shown f*rtlm»

Imlf fm am* of fM'a&43J»# mtfUft* » 1# iM&lsw* bmt % m m

mm

jstl&Xy & & ! % * * % in n s t w s *

to nmmmaaba® t w i n sts*

m i m l y to tho paMltes*

»•

s t r i s t m oppsora to

Csmtsstisii* to othor

partlooXorXy tfco b a g m m b m ^ b m m tom found.

W U N M , G« B* on# BIB V. B 0 R 8 U ?

1902

On the pallia-teetal

or eertleo-meseneephiiXte system of floors*

Brain* 25 s

436-445. BOg&AM* p.

1940

opossum.

Stud loo on the dlimcephalon of the Virginia

fart II*

7Sae fiber connections In normal an#

experimental notorial* GAJAL* a* l&llOB It 1910

J* Comp. Beur.* 721207-297.

la a formulas dal proeeder dal ultra-

bo da plata redneie*

frab. M b . love#b. Biol. Univ.

Madrid* 8*1-26. «,«»»«* 1911

Bletolegle du systems mervenx da 1* horns at das

vertebra#* '»*»'»«» I M S torn,

Faria* A* lelelna* 2 Vela** pp. 1979.

Begeaoratl©** an# raganaratlon of the nervous ayowan#* by B. M* Bay.

London* Oxford Univ. Fra aa*

2 vola.* pp. 769* —

- an# F. da GAS$B0

1955

Blemautea da teenies ml orogre-

flea dal slstsma narvloao. CLAEK* W. 1. La G&OS

1952

connections In the rat. Land*

7ipografla artistic#* Madrid.

An experimental study of the lamia Phil. W a n s , of Soy. See. of

B* 222*1-20.

COMBS* C. MURPHY

1949

Fiber and sell degeneration In the

albino rat brain after hemidaeortieation.

J. Gemp.

SOW.* 90*575-402. M V B M ? c m f H. A. with silver.

1930

Block staining of nervous tissue

Stain W e b . 3*139-147.

74.