The first work of its kind, The History of Medications for Women: Materia medica woman is a richly detailed, far-ranging
205 110 241MB
English Pages 471 [472] Year 2001
Table of contents :
Cover
Half Title
Title Page
Copyright Page
Table of Contents
Dedication
Acknowledgments
Section 1
1. Introduction
The evolution of materia medica woman
The scope of materia medica woman
Research: Problems and solutions
Presentation
Highlights of materia medica woman
Conclusion
Section 2 — Origins
2. The Prescription
The origin of the prescription
The origin of the Rx symbol
References
3. Ergot
Introduction
Introduction of ergot into official medicine
The modern use of ergot
References
4. Lettuce
The lettuce plant
History of lettuce
Historical uses of lettuce
Current use of lettuce
References
5. Mummy Medicine
Wolveridge’s mummy medicine
Mummification
Mummies as medicine
A selection of mummification agents
References
Section 3 — Chronology
6. Assyria
Introduction
The archeological story
The basis of the Assyrian medical system
Fertility and childbirth
The Assyrian herbal
Materia medica in ancient Assyria
References
7. Egypt
Introduction
The basis of the ancient Egyptian medical system
The ancient healers
Ancient Egyptian treatments
Fertility and childbirth
Female disorders
Male disorders
The medical papyri
Examples of women’s materia medica in ancient Egypt
Glossary of ancient Egyptian fertility deities
References
8. Biblical Times
History of the Bible
Biblical medicine
Botany of the Bible
Obstetrics and gynecology in the Bible
A selection of biblical materia medica for women
References
9. Greece and Rome
Introduction
Mythology and Greco-Roman medicine
Medicine in the early classical period
Alexandria
The Greco-Roman period
Medications for women
Examples from Soranus’ materia medica
Glossary of Greco-Roman medical terms
References
10. Byzantium
Introduction
Oribasius of Pergamum
Aetius of Amida
Alexander of Tralles
Paul of Aegina
A selection of Byzantine materia medica for women
Medications for women prescribed by Aetius of Amida
References
11. The Arab Influence
Introduction
Arabian obstetrics and gynecology
Arabian materia medica
Serapeon the Elder
Rhazes
Haly Ben Abbas
Avicenna or Ibn Sina
Albucasis
Avenzoar
Averröes
Safavid medical practice
Arab medicine in the early twentieth century
A selection of Arabian materia medica for women
Arabian drugs and their uses recorded in Francis Adams’ Paul of Aegina
References
12. The Late Middle Ages
Introduction
John of Arderne’s De Arte Phisicali et de Cirurgia
A Leech Book or Collection of Recipes
Medieval Woman’s Guide to Health
A selection of medieval materia medica for women
References
13. The Sixteenth Century
Introduction
The Little Book for Women
Der Schwangern Frauen und Hebammen Rosengarten
The Byrth of Mankynde
De Conceptu et Generatione Hominis or The Expert Midwife
Walter Cary’s A Boke of the Properties of Herbes
William Turner’s Herbal
Turner’s A Booke of the Natures and Properties... of the Bathes
Gerard’s Herball
Paracelsus: A change of direction
A selection of materia medica from the sixteenth century
The Byrth of Mankynde materia medica
References
14. The Seventeenth Century
Introduction
Culpeper’s Directory for Midwives
Culpeper’s Pharmacopoeia Londinensis: or the London Dispensatorie
Culpeper’s A Key to Galen’s Method of Physick
Culpeper’s The English Physician Enlarged
Nicholas Culpeper: A biography
James Wolveridge’s Speculum Matricis: or The Expert Midwives Handmaid
François Mauriceau and The Diseases of Women with Child
A selection of seventeenth century materia medica
References
15. The Eighteenth Century
Introduction
Obstetrics, gynecology and materia medica in the eighteenth century
Fielding Ould’s A Treatise of Midwifery
Fielding Ould (1710–1789): A biography
Carl Linnaeus’ Materia Medica
Carl Linnaeus (1707–1778): A biography
William Smellie’s Treatise on the Theory and Practice of Midwifery
William Smellie’s A Collection of Cases and Observations in Midwifery
William Smellie’s A Collection of Preternatural Cases and Observations in Midwifery
William Smellie (1697–1763): A biography
A selection of eighteenth century materia medica
References
16. The Nineteenth Century
Introduction
Samuel Bard’s A Compendium of the Theory and Practice of Midwifery
Samuel Bard (1742–1821): A biography
Charles Meigs’ The Philadelphia Practice of Midwifery
The Pseudo-Aristotle series
Charles West’s Diseases of Women
Henry MacNaughton Jones and Uterine Therapeutics
Sidney Ringer’s Handbook ofTherapeutics
A selection of nineteenth century materia medica
References
17. The Twentieth Century
Introduction
Obstetrics and gynecology in the early twentieth century
Twentieth century advances in obstetrics and gynecology
A selection of twentieth century materia medica — Individual drugs
A selection of twentieth century materia medica — Drug groups
A selection of twentieth century materia medica — Drugs in pregnancy
Epilogue
A selection of twentieth century ‘alternative medications’
References
Section 4 — Special Subjects
18. Anesthesia and Analgesia and the Curse of Eve
Introduction
Midwifery in the pre-anesthetic days of the early 1800s
Controversies — medical and moral
Comparison between anesthesia and no anesthesia in labor in the nineteenth century
Other inhalation agents
Twilight sleep
Sedatives
Local and conduction analgesia
Anesthesia and maternal mortality
Biographies
Epilogue
References
19. Antiseptics, Antibiotics and Chemotherapy
Introduction
Childbed or puerperal fever
Tuberculosis
Venereal disease and its treatment
Acquired immune deficiency syndrome (AIDS)
Antisepsis
Chemotherapy
Antibiotics
A selection of antimicrobial agents
Biographies
Postscript
References
20. Blood Transfusion and Rhesus Disease
Introduction
Mythology
The early days
Blood pressure
Anticoagulants
Methods of transfusion
Blood groups
Blood transfusion in obstetrics
Congenital hemolytic disease — rhesus disease
References
21. Eclampsia
Introduction
Older treatments
Modern Treatments
Biographies
References
22. Family Planning
Introduction
Contraception through the ages
The condom
The ‘birth control’ movement
Marie Stopes’ Contraception
The legal ‘position’ of contraception in Britain, France and America
Hormonal contraception
Other forms of contraception
References
23. The Menopause
Introduction
The menopause and life expectancy
Menopause through the ages
A selection of treatments to induce menstruation
The twentieth century
Sex organ therapy, old and new
Other landmarks in hormonal therapy
Hormonal therapy: benefits and risks?
Medical, nonhormonal treatment
The menopause in various cultures
Complementary medicine
Traditional Chinese medicine
Conventional medicine and recent progress
Epilogue
References
24. Uterine Stimulants
Introduction
Uterine stimulants for labor
Oxytocin
Sparteine
Quinine and the OBE
Prostaglandins
The induction of labor
Biographies
References
Section 5 — Civilizations
25. The Orient
Introduction
China
Early medical development
A selection of Chinese materia medica
India
The Indian materia medica
A selection of Indian materia medica
References
26. The Americas
Introduction
The native North Americans
European discovery of the Americas
Colonial medicine
The nineteenth century
The twentieth century
Selected American Indian medicines
References
Section 6 — Appendices
Therapeutical Classification of Remedies
Abbreviations Commonly Used in Prescriptions
Sources of Illustrations
Index
THE HISTORY OF
MEDICATIONS
FOR WOMEN
Materia medica woman
THE HISTORY OF
MEDICATIONS
FOR WOMEN
Materia medica woman
Michael J. O'Dowd Consultant Obstetrician Gynaecologist
Portiuncula Hospital, Ballinasloe, Co. Galway, Ireland
CRc press ell! @
Taylo r & Fran cis Group Boca Raton London New York
CRC Press is an imprint of th e Taylor &; Fra ncis Grou p, a n informa business
Library of Congttss Cataloging-in-Publication Data O·Dowd. Michael J. The history of medications for women I by M.J. O·Dowd. p.; em. Includes bibliographical references and index. ISBN 1-85070-002-8 (a1k. paper) I. Materia medica-History. 2. Women-Medical care- History. I. Tide. [DNLM: I. Drug Therapy-history. 2. Genital Di=. Female-history. 3. Alternative Medicine. 4. Genital Oi=. Female-n- nigrum (pepper) 115, 149
pistachio (Pistada tn-tbinthus) 42, 46
Pistada lmtiscus 70
pituitary extract 380--381
Place, Francis 348
placenta 52, 171, 399
biblical references 68
deliveryof92, 212,380,419
medicinal use of 5, 369, 398-399
retention of 149-150, 175, 220, 401
plaisters 181
Planned Parenthood Federation, USA 353
plantain (Plantago) 42, 46, 1SO, 1S1
Pkxaura homoma/Ja 416
Pliny the Elder 71, 78, 84-85, 88, 91, 228
podalic version 145, 333-334
podophyllotoxin 137
Podophyllum ptiatum (may apple) 71, 137
Polygaia tmuifoli4 (Siberian milkwort) 395
polymyxin B 313
pomegranate (Punica granatum) 1SO, 395
as contraceptive 74, 86
biblical references 73-74
pompholyx 190--191
poppy (Papawr) 56, 78-79, 164,284, 39S-396
as aphrodisiac 39
menstrual problem treatment 43
Populus gikadmis 70
Porter, Flint 327
postpartum hemorrhage 132- 133, 167, 220, 226, 419
blood transfusion 324
ergot use 6, 1S, 18, 20
poultices 18 I
pregnancy 174, 18S-186, 227
Ancient Egypt S1, 52, 57
biblical references 67, 69
BUtchkin tkr Schwangtrm Fraum (Little Book for
Women) 142
Dt Conc~tu n Gmn-ationt Hominis (The Expert
Midwife) 152-1 56
Dn- Schwangn-n Fraum und Htbammm Rosmgartm 142- 145
diabetes and 260--261
diagnosis of 52, 57, 58, 81, 114
folic acid and 247
HIV infection and 306-307
medications to avoid 224
multiple pregnancy 69
na~vorrUting186,207,219
teratogens 266-267
thyroid function and 262-263
see also childbirth; labor; midwifery
premature ejaculation 401
premature labor
biblical references 68
drug treatments 258-259
premenstrual syndrome (PMS) 246
Prescort, Oliver 17-18
prescriptions 50
abbreviations used in 429-436
origin of 11, 36
preserves 180
Pritchard, Jack 337
procaine 289
progesterone 5, 251-252, 355,370--371, 416-417
cancer therapy 253
isolation of 355
oral contraception 3SS-356
preterm labor treatment 258
progressive pernicious anemia 246
prolapse I 55, I 73, 200, 208, 227
Ancient Egyptian remedies 58
Byzantine remedies 98
Chinese remedies 401
Greco-Roman remedies 92
Prometheus 78
Prontosil6, 298, 303, 309, 312, 314
propantheline bromide 254
prostaglandin synthetase inhibitors 258
prostaglandins 382-384, 415-416
intracavemosal injection 25~257
prostaglandin E 1 deficiency 246
prostitution, biblical references 70
prothrombin levels, neonate 250
protoveratridine 336
Pruntlla vulgaris 82
Prunus dukis (almond) 188-189
Prunus pmica (peach) 398
Pseudo-Aristode hand-book series 223-224, 366
pseudomenopause, endometriosis treatment 252
pseudopregnancy, endometriosis treatment 252
Ptnwarpus draco 135
puerperal fever 150, 227, 297-303, 309
as contagious disorder 299-302
puerperium 167, 187- 188, 220
Ancient Egypt 52-53, 58
biblical references 69
451
A History ofMtdications for WOmtn
Chinese medicine 40 1
pulsology 392
Punica granatum see pomegranate
purgatives 221, 229
pyocyanase 309-310
Pythagoras 24
Qunrus infoaoria 103
quicksilver see mercury
quinine 5, 234
labor induction 228-229, 235, 382
radiotherapy 253-254
Rail, Theodore 16
Raloxifen 375
rape, biblical references 70
Raynold, Thomas 71, 73, 74, 134, 138, 211, 299
Tht Byrth ofManltynde (The Woman's Book)
146-152, 166-167
Read, Charles 254
Read, Grandey Dick 281
Red Emperor, Shen Nung 390-391
respiratory distress syndrome (RDS) 259-260
Reye, Ralph 244
Reye syndrome 244
Rhazcs 110-111, 115, 344-345
rhesus disease 317,325-328
investigations 326-327
prevention 328
treatment 327-328
rhesus monkey 326
rheumatic fever 243
Rhind, William 135
RhoGam (anti-0 immunoglobulin) 5, 325,
326,328
rhubarb (Rhtumpalmatum) 118-119,395
Ricci, James V. 97, 98-99, 345
Ricinus communis see castor oil plant
Riddle, John 74
Ringer, Sidney 226
Handboolt ofThmzptutics 226-227
rock rose (Cistus incanus) 164
Rodeck, Charles 327
Rohde, Eleanour Sinclair 157
Rome see Greco-Roman period
rose ofJericho (Anastatica hinochuntica) 164
rose of Sharon 164
rose (Rosa) 43, 44, 164-166
apothecaries' rose (R. gallica) 165
R. cmtijlora 165
R. tiamasctna 165
Rosslin, Eucharius 6, 142-145
Dtr Schwangtrn Fraum unJ Htbammm Rounga~142-145
452
Tht Byrth ofManltynde (The Woman's Book) 146-152. 166-167, 380, 412
Rosslin, Eucharius, Jr 145
Rotunda Hospital, Dublin 197, 279, 280
Rouyer, Pierre 50-51
Rowland, Beryll3, 105, 130
rubber 31
rubella 242, 267
congenital rubella syndrome 249
vaccine 248-249
Rubia cortlifolia (Indian madder) 406
RubiA manjista (madder of Bengal) 406
Rubia tinaoria 406
Rubin, Isidor Clinton 254
rue (Ruta gravtolms) 91, 137, 142, 149, 379
as contraceptive 86, 91
Rueff, Jacob 13
Dt Conctptu tt Gmtrationt Hominis (The Expen Midwife) 152-156
Rumtx alpinus (Monks rhubarb) 119
rupture of membranes
Assyrian remedies 44, 47
labor induction 339
Rx symbol 11-13
rye (&cale ctrtale) 15, 16-17
sabadilla (Schomocaulon officina/is) 336
Safavid medical practice: 113
saffron (Crocw sativus) 31, 43, 142, 166
sagapen 178
sage (Salvia officina/is) 374
St Anthony's fire (ergotism) 16-17, 158
StJohn's won (Hyptricum pnforatum) 374
St Valentine 188-189
salep 160
Salernitanus, Nicolas 124
Salerno, Italy 123-124
salicin 243, 410
Salicornia 38
salicylic acid 217,243-244
Salix alba (willow) 217, 243, 395
Sa/sola !tali 38
Salvarsan 308, 314
Salvia officina/is (sage) 374
Sanger, Margaret Higgins 343, 348-349, 353, 355
sanicle (Sanicula turopua) 160
saponins 373, 416
sarsaparilla (Smilax) 159
sassafras (Sassafras albidum) 412
satyrion (Orchis) 160
Sauronatae 164
Savill, Thomas D. 367
savin (funiptrUS sabina) 45, 137, 379
Schiller test 242
lntkx
schistosomiasis 53 Schleifer, Leonard 16
A Co/kction ofPmnnatura/ Ozses ana Obsnvatiom in MUiwifrry 209
Schomocaulon officina/is (sabadilla) 336 Schofield, F.S. 265 scopolamine 40-41, 283, 284 as sedative 286 scopoletin 41 0 &cak cn?ak (rye) 15 &cak cornutum 16 sedatives 157, 286-288 awalgesia 288 avenin (Brornethol) 288 barbiturates 287 chloral hydrate 286 ether-oil 287 lenuce 24 morphine 286 opium 286 paraldehyde 287-288 pentazocine 288 pethldine/meperidine/demerol 288 phenothlazines 287 recral sedatives 287 scopolamine 286 see also analgesia; anesthesia selective estrogen receptor modulators (SERMs) 375 &li mllSSilimse (silver montanum) 149 semen 51, 350 Semmelweis, lgnaz Philipp 302-303 Senecio aumiS (golden ragwortlsquaw weed) 410 Serapeon the Elder 110, 115 Sertiirner, Friedrich Wtlhelm 78, 217 Serullas, Georges Simon 233 Seth 12, 23-24, 55 sex organ therapy 369-370 sexual hygiene, biblical references 66 Shah, Mazar H. 111, 112 Shaw, Wilfred 368 Shen Nung (The Red Emperor) 390-391 shepherd's purse (Ozpsella bui'S4-pastoris) 137-138, 161 Shippen, William, Jr 197 shittah 73 Siberian ginseng (Ekutherococcus smticosus) 398 Siberian milkwort (Polygala tmuifo/ia) 395 Siddah medicine 403 sildenafil (Viagra) 257- 258 silver montanum (&li massilimse) 149 Simpson, James Young 6, 217, 275, 276-282, 331, 415 biography 29(}....292 Sims, James Marion 225, 233 Sloane Manuscript No. 2463 13(}....139 Smellie, William 195, 196
biography 209-211
A Co/kerion ofCues ana Obsnvations in
MiJwifrry 209
Treatise on the Theory ana Practice ofMUiwifrry 205-209 Smilax 159,412 Smithells, R. W. 247, 249 Snow, John 275, 279, 282 biography 293 Solanum sp. 40, 42 Soranus of Ephesus 6, 71, 83,86-89,91, 102, 104, 105, 136,164,165,166,211,299,344.361,366,379 materia medica 91-92 southernwood (Artemisia abrotanumlarbomcms) 87, 150 sow-bread (Cyclamm) 161 soy (Glycine soja) 373 spa waters 159-160, 225 sparteine 381-382 Spencer, Herbert R. 182, 183 sperm whale (Physmr macrocephalus) 139 spermaceti 139 spermatorrhea 227 spinal analgesia 289-290, 338 Spirua ulmaria (meadowsweer) 243 spongia somnifera 124 squaw vine (Mitchtlla repnu) 410 squaw weed (&nt:cio aumiS) 410 Squire, William Wyatt 101, 102, 103, 115, 118, 229 Stachys officina/is (betony) 156, 160 Stachys pa/ustris 82 star anise (!Uicium verum) 395 Stearns, John 6, 17, 18, 217, 414 biography 384 sterility see infertility sterilization 350, 356 stilbestrol 252, 370 stillbirth 151 stinging nettle (Urtica tlioica) 38-39, 43 Stone Age 360 Stopes, Marie Carmichael 343, 348, 354 Contrttception 349-352 storax 43, 45-46 Streptomyces 312-313 streptomycin 267, 312, 417-418 Stroganov, Vasili Vasilievich 335-336 biography 340 Strychnos toxiftra 290 Strynchos nux-vomica 416 stypticin 2 51 styptol251 styrax (Styntx officina/is) 31, 43, 45-46 Styntx calamitis 178 sudorifics 221 sulfonamides 305, 312 Sun Szu-Miao 393
453
A History ofMtdications for WOmm
sweet dover (M~Iilotus) 264-265
sweet William (Armnilt rubra latifolilt) 161
sweetcorn (aa mays) 41 0
syntocinon 20
syntometrine 20
syphilis 116, 158-159, 267, 304,411
treatments 5, 6, 116-117, 158-159, 207, 227,
304,308,311,411-412
syrmaea 31
syrups 180
tamarind ( Tamarindus indica) 150, 159
tamarisk ( Tamarix) 44, 46
tampons, medicated 98, 100
Tao 'Way ofLift 392
tarragon (Artmrisilt dracunculus) 88
Tauret 52, 61
taxanes 253
Taxol6, 39, 253,418
Taxus baccata (common yew) 418
Taxus brrvifoli4 (Pacific yew) 39, 253, 418
teratogens 266-267
terebinthae oleum 40
testicular disease 126, 159
Ancient Egyptian remedies 58
tetracyclines 267, 312
thalidomide 249-250, 266, 267
Theophrastus 81-82
thiopentone 337
Th/4spi burs4-pastoris 137
Thompson, Reginald Campbell37-38, 39-46
Thompson, Samuel 217
thrush 227
Greco-Roman remedies 92
thyroid gland 261-264
hyperthyroidism 263-264
hypothyroidism 263
pregnancy and 262-263
thyrotoxicosis 263-264
thyroxin 261-262
Ttlt, Edward 363
tincture of iodine 233
tobacco 412
topoisomcrase inhibitor 253
touching 207
toxoplasmosis 267
trancxamic acid 251
tribromethanol 337
trichlorethylene 283
trichomoniasis 305
TrigoMi14fomum-grucum (fenugreek) 39, 51, 52, 148
TriUium autum (birth root) 138, 409-410
trimethadione 267
Triticum sp. (com) 46
454
troches 181
Trotula of Salerno 123-124, 133
ru-lal46
tuberculosis 303-304
tubocurarine 416
Turner, Daniel 347
Turner, William 117, 138, 164, 166, 225
Boolr~ ofth~ Natrms and Propmin... ofth~ Bathn 159-160
Hn-ba/157-159 nupcntine31,40,42,46
Tweedy, Hastings 335
biography 340
twilight sleep 283-286
twin pregnancy, biblical references 69
Tyler-Smith, W. 363
tyramine 19
Unani-libb medicine 403-404
ungcntum diapompholigos nichili 191
ungentum gallae 104
unstable bladder 254
Urtica dioica (stinging nettle) 38-39, 43
Ustilago maydis 15
Ustilago uac (com smut) 410
uterine disease 98, 129, 131-132, 157, 158, 173,
209,224,227
American Indian remedies 419
Ancient Egyptian remedies 54-55, 58
Arabian remedies 120
Assyrian remedies 44-46, 47
Byzantine remedies 98, 103, 104
carcinoma 98, 241
see also cervical cancer
discharges 225
Grcco-Roman remedies 92
inversion 220
sec also prolapse; puerperal fever
uterine stimulants see oxytocics
uterus 171, 185
vagina 171, 185, 198
diseases of 227
vaginal examination 199
vaginal pessaries, medicated 100-101
vaginismus 225
Valmana officina/is 82
valerianate of zinc 365
Valium 338
valproic acid 267
van Swieten, Gerhard 197
varicella 267
vasectomy 350, 357
venereal disease 159, 304-305
Jnda
American Indian remedies 419
Assyrian remedies 46, 47
biblical references 70
Greco-Roman remedies 92
see also specific diseases
Venus 24
veratrone 336
V..,-atrum album (white hellebore) 81, 86, 336
V..,-atrum viritk (green hellebore) 336
V..,-bma officina/is (vervain) 191-192
version 145, 333-334
vervain ( V..,-bma officina/is) 192-192
Vesalius, Andreas 152-153
Viagra 257-258
Viburnum opulus (cramp bark) 410
Viburnum prunifolium 251, 410
Vinca roua (periwinkle) 253, 418
violet (Viola odorata) 155
Vuag. R. 256
virginity, test for 124-125
vitamin A 267,306
vitamin K 250
Vitex agnus castus (chaste nee) 39, 46, 158, 227, 373-374
Vitis labrusca 40, 44
Vitis vinifrra (grape) 91
vomiting. in pregnancy 186, 207, 219
von Bayerland, Ortolff 141, 142
Buechkin tin Schwangnm Frauen (Little Book for
Women) 142
von Hohenhcim, Thcophrasrus Philippus Aurcolus Bombasrus
see Paracclsus
von Hoorn, Johan 164
von Rokiransky, Carl 252
von Ziemsscn, Hugh Wilhelm 321-322
vulvitis 227
Wallis Budge, Ernest A. 27-28
warfarin 265, 266-267
wax 31, 138-139
weights and measures 177
West, Charles 224
Diseases ofWomen 224
White, Charles 234, 300
white lily (Lilium candit/um) 148, 162-163
White, Priscilla 261
white wine 31
Whitridge Williams, John 232, 235, 260, 324, 339
Wiener, Alexander 326
Wilbush, Joel 362
wild pea40
Wilde, William R. 137
Williams, John 246
willow bark (Salix alba) 217, 243, 395
Wilson, Robert 359, 371
Ftminin~ Fom~L"T 371-372
windflower {AntmoM pulsatilla) 43-44
wine 91, 161
palm 31
white 31
wintergreen ( Gaulthma procumbms) 243
Wise, Thomas A. 404
Wolveridge, James 3, 27-31, 71. 103, 105, 114, 115, 118,
135. 137. 139. 182, 188-192, 331, 332
Matricis (The Expert Midwives Handmaid)
182-184
wormwood (Artnnisia absinthium) 87
Wren, Sir Christopher 318-319
Sp~culum
Yellow Emperor, Huang 1i 391
yew (Taxus baccata) 418
yohimbine 258
Young. James Harvey 236
aa mays (sweetcorn) 41 0 Zhou Dynasty 391-392
Zidovudine 305-306, 307
zinc oxide 190-191
Zingib..,- officinak (ginger) 203, 397-398
455