Nuclear Medicine Hotlab for NM technology students personal notes by khalid jassim [1 ed.]

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EXAM Q1 Generator Elution Generator Elution: We Need: saline vial, empty 11ml vial for Tc 99m & lead shield, forceps, alcohol wipe. 1- Wipe the saline vial , then insert on its [lace on the generator 2- Wipe 11ml vial , insert it inside lead shield, then insert it on the generator. 3- After 2-3 min or after the bubbles on the saline vial stops, remove Tc99m vial and recap the generator needle. 4- Insert Tc99m vial in the dose calibrator, measure activity, print label return vial in the lead shield & stick the label on it. Elution Concentration: E.X: 38.8 mCi in 10 ml @ 9:00 am

=38.8/10= 3.8 mCi in 1 ml @ 9:00 am

Elution Quality Control: QC 1: Radio Nuclide Purity (99Mo Break Through (ASSAY)): 1234-

Insert Empty lead on Dose calibrator & measure. Insert Tc99m vial in lead, then Insert on Dose calibrator& measure. Insert Empty plastic dipper on Dose calibrator & measure. Insert Tc99m vial in plastic dipper, then Insert on Dose calibrator& measure.

• For QC2 & QC3: Draw 0.03ml of Elution in Insulin Syringe.

QC 2: Chemical Purity (ALUMINA Break Through): 1- From ALUMINA Break Through QC kit, Take one strip 2- Add a drop of standard AL3 on the strip 3- Add a drop of Tc99m elution on the strip AL3 should be < 10 Tc99m

QC 3: Radio Chemical Purity : Impurities Are: ( Free Tc99m, Hydrolyzed Tc02, Tc labelled to other compounds) 1- Add 0.1ml of Acetone on a vial 2- Add a drop of Tc99m elution on a RED strip bottom line 3- Put the strip on the Acetone Vial 4- Wait until it move to the top line 5- Cut the strip on the middle line & put the two strips on two tubes & measure them. Background

0.8

Top free TCO4-

8.8

8.8 - 0.8 = 8

Bottom TCO2-

1.2

1.2-0.8=0.4

=8/8.4*100=95.2 %

Generator Page 2

EXAM Q2 KIT Prepration Prepare HIDA for two patients, 1st pt will be injected @ 10:30 am, 2nd pt will be injected @ 12:00 am,Now the time is 9:00am? ANSWER: • Take vial from the fridge, check Expiry Date • Put it in shield and swap it.

Calculate PT Dose: Adult Dose for HIDA is (5 mCi)

A = Ao e-λt/T half

• For 1st pt we should draw now

• For 2nd pt we should draw now

5.9 + 7 = 12.9 + 10% = 13 mCi , Min activity in HIDA kit is 10 mCi & Max activity is 40 mCi, so we add about 20 mci to HIDA vial.

Calculate Elution concentration NOW: Elution Concentration is 3.8 mCi in 1 ml @ 9:00 am , NOW TIME is 9:30am Volume of activity that we should add to HIDA vial @ 9:30am =

KITS Page 3

• Draw 5.57 ml from elution & add to HIDA vial, draw same amount of air, discard the syrnge. • Print label • Shake and incubate for about 30 min

Qc for HIDA: 123456-

Draw 0.03ml from Tc 99m HIDA vial in Insulin Syringe. Add 0.1ml of H2o on a vial Add a drop on a blue strip bottom line Put the strip on the H2o Vial Wait until it move to the top line Cut the strip on the middle line & put the two strips on two tubes & measure them.

7891011-

Add 0.1ml of 20%Nacl on a vial Add a drop on a orange strip bottom line Put the strip on the 20%Nacl Vial Wait until it move to the top line Cut the strip on the middle line & put the two strips on two tubes & measure them.

Draw Dose for the two patients : Tc 99m HIDA activity 18.3 mCi in 5.6 ml @ 9:30 am , NOW TIME is 9:42am Tc 99m HIDA concentration = 18.3/5.6=3.2679 3.26 mCi/ml • For1 st pt we should draw now

•

• For 2nd pt we should draw now

• Draw the dose for the two pt, & put it in a shield

KITS Page 4

Dose Calibrator QC

A-ACCURACY: • • • •

To show that the Dose Calibrator give correct reading through entire scale. Done annually Should be within -+ 5% of the standard Different long half-life sources with different energies (Low Co57-MED Cs137, Ba133-High Co60) can be measured with the dose calibrator and their value is compared to the expected calculated value.

B-CONSTANCY (PRESICION): • • • •

To show that the Dose Calibrator give reproducible reading on all various isotope setting. Done daily Should be within -+ 5% Cs137 with T half of 30 years, is measured daily

C-LINERATY: • To show that the Dose Calibrator reading is linear from • Tc99m Is measured until it reach 30 , about 96 hr

D-GEOMETRY: • To show that the Dose Calibrator give correct reading regardless of size or geometry. • Done after repair or moving the DC • Done in two ways: 1. 25 Tc99m Is measured, then dilated in (1,2,3,4,5,6,7,8,910 ml Saline) & measured 2. 20 mCi Tc99m Is measured at different distance in DC ( bottom, 2, 4, 6 cm)

Dose Calibrator Page 5

Kits Table #

KIT

MANUFACTU RER

ACTIVITY ADDED TO VIEL mCi

VOLUME ml

STD

MIN

MAX

STD volume

MIN

MAX

1

DMSA

curium

100

1

6

2

MAG-3

curium

80

3

10

3

MDP/HDP

curium

500

3 to10

4

DTPA

curium

5

HIDA

Polatic

6

MIBI

curium

7

Tin Colloid

Polatic

2.7

27

Nano Colloid

Rotop

5

150

1

5

MAA

curium

2.5

100

2.5

10

8

9

300 10

40

2

300

50

Kits Table Page 6

10

5

INCUBATIO N

SHIELF LIFE

MINUTE

HOURS

15-10

ADULT PATIENT DOSE

PEDIATRIC DOSE

mCi

MIN mCi

0.5

NOTES

max localization 3-6 hr, shake 5 min

8hr

>95%

0.8-3.2 mci

8hr

>94%

1-5 mci, baby min .4 0.4 mci

Boil 10-Cool 10 min upright

8--20, baby min 1 mci

Delay at least 2 hr

1

15-30

8hr

renal 1-10 mci

30

5hr

3-5 mCi, baby min .5 0.5 mci

shake 2 min

PARA 13.5-18.9

Boil 10-Cool 10 min upright

1 to 3

10hr

5

QC

20

15

>94%

4hr

2.1

4-5.4mCi

ge 1 mci soilid in eggs

0.2-0.3 ml per injection

6 hr

>95%

Lymph-Sentinal 0.5-2.97 per injection site

8hr

>90%

1-5 mci

0.27

DO NOT VENT, 18 g needle,

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