Neuroblastoma: Clinical and Surgical Management [1st ed. 2020] 978-3-030-18395-0, 978-3-030-18396-7

This book addresses neuroblastoma, a type of embryonic tumor derived from neural crest cells and one of the most frequen

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Neuroblastoma: Clinical and Surgical Management [1st ed. 2020]
 978-3-030-18395-0, 978-3-030-18396-7

Table of contents :
Front Matter ....Pages i-viii
Front Matter ....Pages 1-1
Epidemiology (Jacqueline Clavel, Brigitte Lacour, Paula Rios)....Pages 3-15
Biology of Neuroblastoma (Gudrun Schleiermacher)....Pages 17-28
Neuroblastoma Pathogenesis (Isabelle Janoueix-Lerosey)....Pages 29-56
Neuroblastoma Pathology (Hiroyuki Shimada, Angela R. Sementa, Bruce R. Pawel, Naohiko Ikegaki)....Pages 57-83
Front Matter ....Pages 85-85
Radiology (Hervé J. Brisse, Martijn Verhagen, Kieran McHugh, Claudio Granata)....Pages 87-117
Image-Defined Risk Factors (Giovanni Cecchetto, Tom Monclair, Hervé J. Brisse)....Pages 119-137
Nuclear Medicine Procedures in Neuroblastoma (Arnoldo Piccardo, Rita Castellani, Gianluca Bottoni, Michela Massollo, Giulia Anna Follacchio, Egesta Lopci)....Pages 139-162
Radiotherapy for Neuroblastoma (Tom Boterberg)....Pages 163-170
Front Matter ....Pages 171-171
Spinal Canal Involvement in Peripheral Neuroblastic Tumors (Shifra Ash, Stefania Sorrentino, Kathelijne Kraal, Bruno De Bernardi)....Pages 173-189
Neonatal Neuroblastoma (Dominique Plantaz, Claire Freycon)....Pages 191-203
Low- and Intermediate-Risk Neuroblastoma (Vanessa Segura, Adela Cañete)....Pages 205-212
High-Risk Neuroblastoma and Current Protocols (Katherine K. Matthay, Dominique Valteau-Couanet)....Pages 213-235
Immunotherapy (Francesca del Bufalo, Franco Locatelli)....Pages 237-269
Prognostic Factors and Risk Stratification (Meredith S. Irwin)....Pages 271-292
Front Matter ....Pages 293-293
Biopsy of Neuroblastoma (Dhanya Mullassery, Laurence Abernethy, Rajeev Shukla, Paul D. Losty)....Pages 295-311
Surgical Techniques (James A. Saltsman III, Nicole J. Croteau, Michael P. LaQuaglia)....Pages 313-325
Surgical Strategies for High Risk Neuroblastoma (Sanjeev A. Vasudevan, Jed G. Nuchtern)....Pages 327-336
Surgical Strategies for Neuroblastoma with Spinal Canal Involvement (Luca Pio, Thomas Blanc, Christophe Glorion, Stephanie Puget, Michel Zerah, Sabine Sarnacki)....Pages 337-342
Neuroblastoma: Minimally Invasive Surgery (Jörg Fuchs, Steven W. Warmann)....Pages 343-355
Robotic Surgery for Neuroblastoma (Luca Pio, Thomas Blanc, Girolamo Mattioli, Yves Heloury, Sabine Sarnacki)....Pages 357-362
Complications of the Surgical Management of Children with Neuroblastoma (Andrew M. Davidoff)....Pages 363-374
Palliative Care (Alessandro Inserra, Alessandro Crocoli)....Pages 375-383

Citation preview

Neuroblastoma Clinical and Surgical Management Sabine Sarnacki Luca Pio Editors

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Neuroblastoma

Sabine Sarnacki  •  Luca Pio Editors

Neuroblastoma Clinical and Surgical Management

Editors Sabine Sarnacki Department of Pediatric Surgery Necker - Enfants Malades Hospital Assistance Publique Hopitaux de Paris University of Paris Paris France

Luca Pio Department of Pediatric Surgery Necker - Enfants Malades Hospital Assistance Publique Hopitaux de Paris University of Paris Paris France

ISBN 978-3-030-18395-0    ISBN 978-3-030-18396-7 (eBook) https://doi.org/10.1007/978-3-030-18396-7 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Foreword

Sabine Sarnacki and Luca Pio have created a comprehensive text on neuroblastoma. This is a timely submission. The roster of authors are all international experts on the diagnosis and management of neuroblastoma. Drs. Sarnacki and Pio have compiled a text that provides information extending from the epidemiology of this disease to its imaging and, most importantly, the clinical management and surgery. This text will provide the reader a single source of the most current knowledge on all aspects of neuroblastoma. They are to be congratulated for this singular effort providing us a veritable wealth of information on neuroblastoma. I believe it will serve as an invaluable reference text for readers of all levels.

Robert C. Shamberger Surgery, Boston Children’s Hospital Harvard Medical School Harvard, MA, USA Robert E. Gross Professor of Surgery Harvard Medical School Harvard, MA, USA Chief of Surgery Boston Children’s Hospital Boston, MA, USA

v

Contents

Part I Epidemiology, Biology and Pathology Assessment 1 Epidemiology����������������������������������������������������������������������������������������������   3 Jacqueline Clavel, Brigitte Lacour, and Paula Rios 2 Biology of Neuroblastoma ������������������������������������������������������������������������  17 Gudrun Schleiermacher 3 Neuroblastoma Pathogenesis��������������������������������������������������������������������  29 Isabelle Janoueix-Lerosey 4 Neuroblastoma Pathology ������������������������������������������������������������������������  57 Hiroyuki Shimada, Angela R. Sementa, Bruce R. Pawel, and Naohiko Ikegaki Part II Imaging 5 Radiology����������������������������������������������������������������������������������������������������  87 Hervé J. Brisse, Martijn Verhagen, Kieran McHugh, and Claudio Granata 6 Image-Defined Risk Factors���������������������������������������������������������������������� 119 Giovanni Cecchetto, Tom Monclair, and Hervé J. Brisse 7 Nuclear Medicine Procedures in Neuroblastoma������������������������������������ 139 Arnoldo Piccardo, Rita Castellani, Gianluca Bottoni, Michela Massollo, Giulia Anna Follacchio, and Egesta Lopci 8 Radiotherapy for Neuroblastoma������������������������������������������������������������ 163 Tom Boterberg Part III Clinical Management 9 Spinal Canal Involvement in Peripheral Neuroblastic Tumors ������������ 173 Shifra Ash, Stefania Sorrentino, Kathelijne Kraal, and Bruno De Bernardi 10 Neonatal Neuroblastoma �������������������������������������������������������������������������� 191 Dominique Plantaz and Claire Freycon vii

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Contents

11 Low- and Intermediate-Risk Neuroblastoma������������������������������������������ 205 Vanessa Segura and Adela Cañete 12 High-Risk Neuroblastoma and Current Protocols��������������������������������� 213 Katherine K. Matthay and Dominique Valteau-Couanet 13 Immunotherapy������������������������������������������������������������������������������������������ 237 Francesca del Bufalo and Franco Locatelli 14 Prognostic Factors and Risk Stratification���������������������������������������������� 271 Meredith S. Irwin Part IV Surgery 15 Biopsy of Neuroblastoma�������������������������������������������������������������������������� 295 Dhanya Mullassery, Laurence Abernethy, Rajeev Shukla, and Paul D. Losty 16 Surgical Techniques ���������������������������������������������������������������������������������� 313 James A. Saltsman III, Nicole J. Croteau, and Michael P. LaQuaglia 17 Surgical Strategies for High Risk Neuroblastoma���������������������������������� 327 Sanjeev A. Vasudevan and Jed G. Nuchtern 18 Surgical Strategies for Neuroblastoma with Spinal Canal Involvement ������������������������������������������������������������������������������������ 337 Luca Pio, Thomas Blanc, Christophe Glorion, Stephanie Puget, Michel Zerah, and Sabine Sarnacki 19 Neuroblastoma: Minimally Invasive Surgery������������������������������������������ 343 Jörg Fuchs and Steven W. Warmann 20 Robotic Surgery for Neuroblastoma�������������������������������������������������������� 357 Luca Pio, Thomas Blanc, Girolamo Mattioli, Yves Heloury, and Sabine Sarnacki 21 Complications of the Surgical Management of Children with Neuroblastoma���������������������������������������������������������������������������������� 363 Andrew M. Davidoff 22 Palliative Care�������������������������������������������������������������������������������������������� 375 Alessandro Inserra and Alessandro Crocoli

Part I Epidemiology, Biology and Pathology Assessment

1

Epidemiology Jacqueline Clavel, Brigitte Lacour, and Paula Rios

Neuroblastomas are rare diseases, and as such their surveillance requires specific large-scale reliable population registries. We are more and more able to describe neuroblastomas and other embryonal tumors all over the world, but information is still insufficient and fragile in low-income countries, now prioritized in the international strategies of cancer surveillance. Epidemiological research on risk factors, also, is limited by the rarity of the disease and mostly relies on case–control studies, that is, studies performed at the time of diagnosis, getting information by interview and, in some countries, from databases like birth certificates. Lack of knowledge about risk factors is important, and the international epidemiology consortiums are currently strengthening their efforts on etiological research.

1.1

Descriptive Epidemiology

In the International classification of disease for oncology (ICD-O-3) [1], neuroblastomas are classified into the two morphologic codes 95003 (neuroblastoma, the most frequent) and 94903 (ganglioneuroblastoma, the best differentiated form of neuroblastoma). Both are grouped in the category IV (Tumors), subgroup IV.a (neuroblastomas) of the International classification for childhood cancers (ICCC) [2].

J. Clavel (*) · B. Lacour CRESS, UMRS1153, INSERM, Université Paris-Descartes, Paris, France National Registry of Childhood Cancers, APHP Hôpital Paul Brousse, Villejuif, France CHU de Nancy, Vandoeuvre-lès-Nancy, France e-mail: [email protected] P. Rios CRESS, UMRS1153, INSERM, Université Paris-Descartes, Paris, France © Springer Nature Switzerland AG 2020 S. Sarnacki, L. Pio (eds.), Neuroblastoma, https://doi.org/10.1007/978-3-030-18396-7_1

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J. Clavel et al.

In this chapter, the epidemiological features of neuroblastomas are described using the 2000–2013 data extracted from the French National Registry of Childhood Cancer (RNCE) (http://rnce.inserm.fr). The RNCE registers 130–150 new cases of neuroblastoma aged under 15 years every year.

1.1.1 Incidence and Epidemiological Features The annual age-standardized incidence rate is around 14 cases per million of children aged 0–14 years (Table 1.1). Neuroblastomas are mostly diagnosed before the age of 5 years (85%), and 40% occur in infancy. They are very uncommon after the age of 10 years. Annual incidence rates vary from 73 cases per million in infancy to 1 case per million after the age of 10 years. Neuroblastomas are the most frequent tumors diagnosed in neonates (