MICR220 Guide

Table of contents :
OBJECTIVES OF THE UNIT
LEARNING OUTCOMES
STRUCTURE OF THE UNIT
UNIT COORDINATOR AND TEACHING STAFF
SESSION TIMES AND LOCATIONS
UNIT RESOURCES
ASSESSMENTS
GRIEVANCES AND STUDENTS RIGHTS & RESPONSIBILITIES
STUDENT FEEDBACK
TIMETABLE 2023
BRIEF LEARNING OUTCOMES AND RECOMMENDED TEXTBOOK CHAPTERS

Citation preview

SCHOOL OF BIOMEDICAL SCIENCES

MICR2209 Introduction to Infectious Diseases and Immunology

UNIT GUIDE SEMESTER 2, 2023 UNIT COORDINATOR DR CALILA SANTOS

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CONTENTS OBJECTIVES OF THE UNIT ......................................................................................... 3 LEARNING OUTCOMES ............................................................................................ 3 STRUCTURE OF THE UNIT ........................................................................................... 4 UNIT COORDINATOR AND TEACHING STAFF.......................................................... 4 SESSION TIMES AND LOCATIONS............................................................................. 5 UNIT RESOURCES ...................................................................................................... 6 ASSESSMENTS............................................................................................................ 8 GRIEVANCES AND STUDENTS RIGHTS & RESPONSIBILITIES ...................................... 9 STUDENT FEEDBACK ................................................................................................. 9 TIMETABLE 2023 ...................................................................................................... 10 BRIEF LEARNING OUTCOMES AND RECOMMENDED TEXTBOOK CHAPTERS ...... 12

All material reproduced herein has been copied in accordance with and pursuant to a statutory licence administered by Copyright Agency Limited (CAL), granted to the University of Western Australia pursuant to Part VB of the Copyright Act 1968 (Cth). Copying of this material by students, except for fair dealing purposes under the Copyright Act, is prohibited. For the purposes of this fair dealing exception, students should be aware that the rule allowing copying, for fair dealing purposes, of 10% of the work, or one chapter/article, applies to the original work from which the excerpt in this course material was taken, and not to the course material itself.

© The University of Western Australia 2015

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MICR2209 INTRODUCTION TO INFECTIOUS DISEASES AND IMMUNOLOGY OBJECTIVES OF THE UNIT Since the earliest recorded suggestions that invisible organisms might cause disease (e.g. Lucretius, about 98–55 BC), the first recorded observations of microbes by Robert Hooke (1635–1703), Edward Jenner’s use of material from cowpox lesions to vaccinate humans against smallpox, and John Snow’s discovery of the source of a cholera outbreak in England in 1849, enormous advances have occurred in the development of knowledge of microbes, infectious diseases and immunology. Introduction to Infectious Diseases and Immunology (MICR2209) provides an up-to-date overview of viral, bacterial, protozoan and fungal infections; the immune response to infection; and how these aspects of human disease are linked. Students who complete this unit will understand the causes, sources and effects of infectious disease; be familiar with the mechanisms of immunological response to infectious agents and know how such knowledge can be used to prevent disease. MICR2209 is a required second year unit for students majoring in Microbiology and Immunology at the University of Western Australia. Prerequisites are SCIE1106 Molecular Biology of the Cell, plus one of the first-year biology units BIOL1130, ANHB1101 or ANHB1102, or IMED1001 and IMED1002.

LEARNING OUTCOMES Assessment Activity

Outcomes Students will be able to recall and integrate key knowledge and concepts about:  Components and function of the immune system  Innate and adaptive immunity  Viral genetics, detection and culture  RNA and DNA viruses, and viral diseases  Protist and fungal diseases and their sources  Bacterial pathogens, diseases and their sources, antibiotics and antibiotic resistance

Mid-semester MCQ and Final Exam

Students will acquire practical knowledge of:  Methods used in analysis and identification of immune cells  Critical skills used to solve clinical cases  Biological, molecular and bioinformatics techniques used in virology  Techniques used in the study and diagnosis of fungal and protist disease  The use of phenotypic assays for bacterial identification  Methods for bacterial culture and staining

Laboratory and workshop assessments

Students will have the opportunity to develop verbal communication skills through interactive sessions

Lab and tutorial sessions

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STRUCTURE OF THE UNIT The unit is presented as 4 discrete modules including: Module

Title

Module coordinator (s)

Email address

1

Introduction to immunology and the immune system

Dr Calila Santos

[email protected]

2

Introduction to viruses and viral diseases

A/Prof Allison Imrie

[email protected]

3

Introduction to bacteria and bacterial diseases

Dr Kate Hammer and Dr Tim Barnett

[email protected] [email protected]

4

Introduction to diseases caused by fungi and protists

Prof Barbara Chang and A/Prof Chris Peacock

[email protected] [email protected]

Each module involves a series of lectures (5–6), online workshops and tutorials. The practical component of all modules will be delivered as four intensive (3-hour) wet lab in the L Block G15 and G17 laboratories.

UNIT COORDINATOR AND TEACHING STAFF Dr Calila Santos (Unit coordinator) Room 1.19, Division of Infection & Immunity, School of Biomedical Sciences, L Block, QEII Medical Centre. Telephone: 6457 4658, [email protected]

Teaching staff: CS: Dr Calila Santos AI: A/Prof Allison Imrie KH: A/Prof Kate Hammer TM: Dr Tim Barnett BC: Prof Barbara Chang CP: A/Prof Chris Peacock SV: Ms Sarah Power MV: Ms Marivic Weeratunga

[email protected] [email protected] [email protected] [email protected]

[email protected] [email protected] [email protected] (Lab preparation) [email protected] (Class allocation)

Contacting academic and professional staff by email    



All general queries related to this unit should be directed to the Unit Coordinator (Dr Calila Santos) via her email address. Any queries related to the content for specific modules in the unit should be directed to the respective module coordinator. Always include a subject heading with the tagline “RE: MICR2209 - ….” as we receive emails from students in numerous units. All email messages should be polite, considerate, and contain correct grammar and spelling. All should begin with an appropriate salutation, e.g. “Dear…”, and end with a suitable closing, e.g. “Regards…”. Writing a professional email is a generic skill that you should acquire while at UWA. Do not expect an answer to an email outside of business hours (Monday – Friday, 9.00 – 17.00).

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Please check the “Announcement” section in the unit’s LMS page before sending an email. Your question may have already been addressed.

SESSION TIMES AND LOCATIONS Lectures All lectures will be delivered face-to-face, and attendance is highly recommended. Lectures will be delivered in FJ Clark Lecture Theatre QEII P block as per timetable (pages 10 and 11).

Workshops Over the semester, you will have two online workshops (immunology, virology). Each workshop is comprised of a series of short readings, clinical cases, video links and study questions. You will have approximately 2 weeks to complete each workshop. Each workshop will be assessed via an online quiz.

Tutorials Four online tutorials have been scheduled. The aims of MICR2209 tutorials are to revise each workshop prior to assessment (quiz), and to answer relevant questions about each module content. Tutorials follow a Question & Answer (Q&A) format and rely on the participation of students. Details about each tutorial session (e.g. link) will be provided closer to the tutorial date. Attendance is highly recommended.

Laboratory session You will have four compulsory laboratory sessions. The laboratory practical session will be delivered G15 Laboratory QEII L block, and you must enrol in one of the three session options laboratory sessions: Wednesday or

1 - 4 pm

Thursday or

9 - 12 pm

Thursday

1 - 4 pm

G15 and G17 Laboratories QEII L block

Four compulsory laboratory sessions  Immunology/ Virology lab (week 6)  Bacteriology labs 1 and 2 (weeks 8 and 9)  Fungi/ Protists lab (week 11)

Queries regarding timetables and schedules (i.e. timetable clashes) are to be directed to Administrative Officer Marivic Weeratunga via the email [email protected]. Laboratory class requirements 



It is compulsory for all students to attend face-to-face laboratories to undertake experimental work. Attendance records will be kept on file and no laboratory classes can be re-run due to setup and reagent costs and venue availability. A student is considered to be absent if more than 15 minutes late for a practical, without a substantiated reason. In the event of non-attendance, an application for special consideration no later than three university working days after the date of the missed session is required. If a session is missed without accepted excuse, the laboratory assessment cannot be undertaken. For more details, visit: https://www.uwa.edu.au/students/my-course/examsassessments-and-results/special-consideration

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You must complete the PC2 lab safety induction and pre-labs before attending the lab. Inductions will be delivered online via LMS. Failure to complete all inductions will prevent you from entering the lab. An online copy of the Laboratory Manual will be available in the LMS at least two weeks before the lab class. It is important that you read the manual before coming to class, to familiarise yourself with the experiments, main concepts and study questions. Please note that a hard copy will be given to you in the lab, and that you are not required to print a copy.

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UNIT RESOURCES Learning Management System (LMS) All course materials, including lecture handouts, lab, tutorial and workshop information, and notices about the unit will be posted on the Blackboard LMS site for the unit. For assistance with the LMS, do not contact the unit coordinator. On the LMS site, select the “Student LMS Help” link, or visit https://www.uwa.edu.au/library/help-and-support, or in person at the Reid Library and the Science Library. Or, browse answers online anytime or ask a question through askUWA available at: http://ipoint.uwa.edu.au

Lecture Capture System UWA’s Lecture Capture System (powered by Echo360) captures lectures in selected venues or recording prepared by lecturers and publishes them in LMS. MICR2209 lectures will be captured as audio and screen capture and will be available for streaming. All lectures will be uploaded to the LMS as per timetable. Students have access to two discussion forums. The Student Discussion Board has been set up of students to communicate and interact amongst themselves. Students are encouraged to ask peers questions about lectures, labs and tutorials; or post any interesting content related to the Unit. The Question and Answers board has been set up for students to post general questions about the unit, directed to the unit coordinator. Discussion forums will be monitored weekly. Students are encouraged to preferentially contact academics during lectures and other presential activities.

Textbook It is highly recommended that you have regular access to the following text:  Prescott's Microbiology, Willey et al., 12th ed., McGraw Hill Publishers, 2023. https://onesearch.library.uwa.edu.au/permalink/61UWA_INST/khft73/alma991339823902101

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Basic Immunology, Abbas et al., 7th ed., Elsevier Saunders, 2023. https://onesearch.library.uwa.edu.au/permalink/61UWA_INST/1vk1d8f/alma991462333602101

Background Resources (MICR2208) Students who have not completed Introduction to Microbiology MICR2208 and who have received no training in microbiology are likely to lack knowledge central to understanding the content of MICR2209. To address this limitation the lecture notes from the MICR2208 unit (2023) have been made available to MICR2209 students on the LMS site, for study or revision. Amongst these, the lectures from MICR2208 identified below are considered particularly relevant and important background. In addition to the MICR2208 resources, sections in the textbook (Prescott’s Microbiology 12th ed. (PM)) that cover important background information are identified.

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Please note that these chapters contain much more detail than is necessary for students to learn they are provided for reference only. Students with no background in microbiology are strongly advised to investigate the content of the resources noted below prior to and during this unit. General:  Lecture 1 (History and Scope of Microbiology); PM Chapter 1  Lecture 2 (Taxonomy of Microorganisms); PM Chapter 19 Module 1: Introduction to immunology and the immune system:  No relevant lectures; PM Chapter 32 and 33 Module 2: Introduction to viral diseases:  Lectures 10 and 11; PM Chapter 6 Module 3: Introduction to bacterial diseases:  Lectures 3 and 4 (Prokaryotic structure and function); PM Chapter 3  [Lectures 5 and 6 cover many important bacteria, but not exclusively pathogens. PM Chapters 21, 22 and 23 provide reference information on most bacteria]  Lecture 14 (Bacterial nutrition, culture media and cultivation) and Lecture 15 (Growth and measurement of bacterial growth); PM Chapter 7 and 8 Module 4: Introduction to diseases caused by protists and fungi:  Lecture 8 (Eukaryotic microbes); PM Chapter 5  Lecture 9 (Fungi); PM Chapter 25  Lectures 12 and 13 (Protists); PM Chapter 24

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ASSESSMENTS Summary   

Final examination – 55% Mid-semester exam – 20% Laboratory and workshop assessments – 25%

Details Event

Marks

Content

55%

All lectures and laboratory

Final examination

Format Closed book MCQ/EMQ 2 hours

20%

Lectures 1–13

Closed book MCQ/EMQ 50 minutes

Immunology workshop quiz

6%

Immunology online workshop

Online MCQ 25 minutes

Virology workshop quiz

6%

Virology online workshop

Online MCQ 25 minutes

Mid semester exam

Laboratory

13%

Laboratory classes

SAQ (completion of laboratory manual)

Date and Venue End of semester exam period Venue: to be announced Week 7 - see class allocation Wed, 10:00 -12:00, QE2P: [G16] Mary Lockett Lecture Theatre Wed, 15:00 - 17:00, QE2P: [G31] FJ Clark Lecture Theatre Thurs, 12:00 - 14:00, QE2P: [G16] Mary Lockett Lecture Theatre Week 4 – quiz will be available for 24 hours, from 1 pm 14/8 to 1 pm 15/8 Venue: Online/ LMS Week 7 – quiz will be available for 24 hours, from 1 pm 11/9 to 1 pm 12/9 Venue: Online/ LMS Lab manual questions to be completed and submitted prior to leaving each lab session Venue: QE2L: [G15 and 17] Microbiology Lab

MCQ (multiple-choice questions); EMQ (extended multiple-choice questions); SAQ (short-answer questions)

Assessment Notes MCQ lecture test: approximately 40 multiple-choice questions (~3 per lecture). Closed book. Students should enrol in one of the above session times. Workshop assessments: there are two MCQ quizzes of approximately 20 questions each, which will be made available on the LMS unit site two weeks after the online workshop has opened. The quiz will be available for 24 hours, and you can sit the exam at any time on the date of the quiz. You will have only one attempt to complete the quiz (once you start the quiz, you must finish it). It is essential that you are ready, have sufficient time, and have a strong and reliable internet connection before opening and beginning the quiz. Laboratory assessments: you are expected to answer all study questions in the laboratory manual during the laboratory classes and submit your manual to your demonstrator to be graded before you leave the laboratory. The manual will be marked and retuned to you by the end of the laboratory week. In addition, approximately 10 MCQ questions, related to the laboratory content, will be included in the final examination. Final exam: MCQs and EMQs covering all lectures and laboratory. Detailed format information and practice questions will be provided during the semester.

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Penalty for late assignments and absences A penalty of 5 per cent of the possible mark allocated for the assessment item is deducted per day for the first 7 days (including weekends and public holidays), after which the assigned work is not accepted. Each 24-hour block is recorded from the time the assignment is due. Assessments submitted later than 7 days after the deadline receive a mark of zero, unless an application for mitigation is approved in accordance with the University Policy on Assessment: Special Consideration (UP11/23). To avoid a mark penalty, if an assessment task is missed due to illness or another unforeseeable cause, special consideration will need to be granted by the Medical Faculty’s Student Office. Applications for special consideration are submitted through askUWA.

GRIEVANCES AND STUDENTS RIGHTS & RESPONSIBILITIES Students are reminded that the University has adopted a comprehensive Charter of Student Rights and a Grievance Resolution policy. The Charter is available at https://www.uwa.edu.au/students/mycourse/university-charter and the grievance policy is available at http://www.student.uwa.edu.au/life/complaints

Appeals against academic assessment If students feel they have been unfairly assessed, they have the right to appeal their mark by submitting an Appeal Against Academic Assessment form to the Head of School and Faculty Office. The form must be submitted within twenty working days of the release of the formal result. It is recommended that students contact the Guild Education Officers to aid them in the appeals process. They can be contacted on +61 8 6488 2295 or [email protected]. Full regulations governing appeals procedures are available from Academic Policy Services, available online at https://www.web.uwa.edu.au/university/complaints/students

STUDENT FEEDBACK We recognise students as responsible active participants in their educational experience by way of providing valuable feedback on learning and teaching and their student experience. By answering the Student Experience of Learning and Teaching (SELT) survey, and providing feedback on your experience of learning and teaching in MICR2209, we are able to modify future delivery and content of the unit, ensuring high quality teaching and learning practices at UWA. Your feedback is used by the lecturing and demonstrating staff to develop their individual teaching approaches, unit content and student engagement methods. It may also be used to support excellence in teaching and promotion applications.

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MICR2209 INTRODUCTION TO INFECTIOUS DISEASES AND IMMUNOLOGY TIMETABLE 2023 Lectures: Mondays (selected weeks) and Tuesdays, QE2P: G.31 FJ Clark Lecture theatre Workshops: Two self-guided, online workshops, followed by multiple-choice question online quizzes Tutorials: Online via MS Teams on selected weeks Laboratory classes: Weeks 6, 8, 11 and 12 (allocation via CAS), QE2L:G15 and 17 Microbiology Laboratory CS: Dr Calila Santos; AI: A/Prof Allison Imrie; KH: Dr Kate Hammer; TB: Dr Timothy Barnett; BC: Prof Barbara Chang; CP: A/Prof Chris Peacock

WEEK

DATE

TIME

ACTIVITY

TOPIC

LECTURER

Mon 24/7

12 pm

Lecture

L1: Introduction to the Unit and Host-Parasite relationships

CS

Module 1: Introduction to immunology and the immune system 1/30

2/31

3/32

Tue 25/7 Tue 25/7 Mon 31/7 Tue 1/8 Tue 8/8 Mon 14/8

2 pm

Lecture

L2: Immunity and the immune system

3 pm

Lecture

L3: Innate immunity

12 pm

Workshop

CS

2 pm 3 pm 2 pm 3 pm

Mon 21/8

36

CS

Lecture Tutorial

1 pm

Online QUIZ

L6: Adaptive immunity - humoral immune responses L7: Introduction to immunopathology Immunology workshop revision and lecture Q&A

CS CS

Immunology Workshop Online MCQ Quiz (quiz available for 24 hours) Module 2: Introduction to viral diseases

Tue 15/8

6/35

Selfguided

L5: Adaptive immunity - cell mediated immune responses

12 pm

4/33

5/34

Lecture

Online activity available - Introduction to Immunology and The Immune System L4: The major histocompatibility complex and antigen presentation

2 pm 3 pm 12 pm

Tue 22/8

2 pm

Tue 29/8

2 pm

3 pm

3 pm

Wed or Thurs 30 or 31/9 - see class allocation

Lecture Workshop Lecture

Lecture

L8: Introduction to virology

AI

L9: Virus genomes and genetics

AI

Online activity available - Diagnosis of Viral Infections L10: Virus detection and cultivation L11: The DNA viruses and the diseases they cause L12: The RNA viruses and the diseases they cause L13: Introduction to viral pathogenesis

Selfguided AI

AI

Immunology and Virology Lab LAB 1

(Students must complete the online PC2 lab safety induction and online pre-lab before attending the lab)

Venue: QE2L: [ G15 and G17] Microbiology Lab

STUDY BREAK

10

CS

WEEK

DATE Mon 11/9

TIME

ACTIVITY

TOPIC

LECTURER

12 pm

Tutorial

Virology workshop revision, post lab 1 and lecture Q&A

1 pm

Online QUIZ

Virology Workshop Online MCQ Quiz (quiz available for 24 hours)

CS/AI

Module 3: Introduction to bacterial diseases 7/37

Tue 12/9

2 pm 3 pm

Wed or Thurs 13 or 14/9 - see class allocation Mon 12 pm 18/9 8/38

Tue 19/9

2 pm 3 pm

Wed or Thurs 20 or 21/9 - see class allocation Tue 26/9 9/39

2 pm 3 pm

Wed or Thurs 27 or 28/9 - see class allocation Mon 12 pm 2/10

Tue 3/10 Mon 9/10 Tue 10/10

2 pm 3 pm 12 pm 2 pm 3 pm

Wed or Thurs 11 or 12/10 - see class allocation Mon 12 pm 16/10 12/42

EXAM Lecture Lecture LAB 2

Lecture

LAB 3 Tutorial

L14: Introduction to bacteriology L15: Food and waterborne bacterial diseases

KH

MID-SEMESTER LECTURE EXAM (lectures 1-13) Venue: QE2P: [G.31] FJ Clark Lecture theatre and QE2P: [G16] Mary Lockett Lecture Theatre (allocation via CAS) L16: Airborne bacterial diseases L17: Direct contact bacterial diseases

KH

L18: Opportunistic bacterial diseases Bacteriology Lab (Students must complete online pre-lab before attending the lab)

Venue: QE2L: [ G15 and G17] Microbiology Lab

L19: Antibacterial agents: development and mode of action L20: Antibacterial agents: resistance and gene transfer Bacteriology Lab (follow up) (Students must complete online pre-lab before attending the lab)

Venue: QE2L: [ G15 and G17] Microbiology Lab Bacteriology review and Q&A session

CS

TB

CS CS/KH

Module 4: Introduction to fungal and protozoal diseases

10/40

11/41

Lecture

Tue 17/10

2 pm 3 pm

Lecture Lecture Lecture LAB 4 Tutorial Lecture

L21: Introduction to mycology and fungal diseases

BC

L22: Systemic and opportunistic fungal diseases

BC

L23: Introduction to protozoan diseases - direct contact, food- and water-borne protozoan diseases

CP

L24: Arthropod-borne protozoan diseases

CP

L25: Helminth infections

CP

Mycology and Parasitology Lab (Students must complete online pre-lab before attending the lab)

Venue: QE2L: [ G15 and G17] Microbiology Lab

Mycology/Parasitology lecture and Q&A post-lab L26: Introduction to infectious diseases epidemiology Unit review and student feedback

CS CS/CP/BC CS

Queries regarding timetables and schedules (i.e. timetable clashes) are to be directed to Teaching Operations Officers [email protected]

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BRIEF LEARNING OUTCOMES AND RECOMMENDED TEXTBOOK CHAPTERS

LECTURE TOPIC

BRIEF LEARNING OUTCOMES At the end of these lectures, you will be able to describe and explain the following:

CHAPTER IN PRESCOTT’S MICROBIOLOGY 12th ed.*

• concepts of infection, pathogenicity, virulence, latency • phases of infectious diseases Chapter 35 • components of the infection chain • virulence factors of microbes Module 1: Introduction to immunology and the immune system Also recommended: Basic Immunology, Abbas et al., 6th ed., Elsevier Saunders, 2020 • fundamental concepts of immunity L2: Immunity & The Chapter 32 • major cell types of the immune system and their Immune System lineage, and functions • primary and secondary lymphoid tissues • physical and chemical barriers to infection • receptors of the innate immune system • effector cells and functions - phagocytosis, cytokines L3: Innate immunity Chapter 32 and inflammation, interaction of innate and adaptive immune systems • complement system • major cell types of the cell mediated immune L4: Adaptive immunity Chapter 32 response cell mediated immune Chapter 34 • T cell development, maturation, and different subsets responses part I L1: Host-Parasite relationships

L5: Adaptive immunity cell mediated immune responses part II L6: Adaptive immunity: humoral immune responses L7: Introduction to immunopathology

• the major histocompatibility complex (MHC) • interaction of MHC and the T cell receptor • T cell activation and regulation • activation of B lymphocytes and production of antibodies • antibody structures, functions, generation of antibody diversity • immunopathology and hypersensitivity disorders • congenital and acquired immunodeficiencies • immunologic tolerance and autoimmunity

Chapter 33

Chapter 33

Chapter 33 Chapter 34

Module 2: Introduction to viral diseases L8: Introduction to virology and virus classification

• basic components of virus morphology, structure, and taxonomy

L10: The DNA viruses and the diseases they cause

• virus identification samples, methods • dynamics of viraemia and host anti-virus immune responses • Herpesviruses, Human papilloma virus • Hepatitis B virus

L11: The RNA viruses and the diseases they cause

• Influenza virus, Rotavirus • Human immunodeficiency virus

L9: Virus detection and cultivation

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Chapter 6 Chapter 6 Chapter 26 Chapter 6 Chapter 38

• Coronavirus

L12: SARS-CoV-2 and COVID-19

Chapter 38

• viral disease mechanisms • ways viruses can enter the host • localised and systemic viral infections

L13: Introduction to viral pathogenesis

Chapter 38

Module 3: Introduction to bacterial diseases L14: Introduction to bacteriology L15: Food and waterborne bacterial diseases L16: Airborne bacterial diseases L17: Direct contact bacterial diseases L18: Opportunistic bacterial diseases L19: Antibacterial agents: development and mode of action L20: Antibacterial agents: resistance and gene transfer

• bacterial structures and functions • bacterial growth, factors affecting growth, bacterial culture, growth media • bacterial taxonomy • organisation and defences of gastrointestinal tract • food poisoning, botulism, cholera, diarrhoea, typhoid, salmonellosis, dysentery • organisation and defences of respiratory tract • streptococcal infections, pertussis, TB, meningitis, pneumonias • types of direct contact • clostridial, staphylococcal, streptococcal infections • sexually transmitted infections • risk factors and scenarios for opportunistic infections • surgical site infections and biofilms • antibiotic-associated diarrhea, febrile neutropenia, pneumonia • history of chemotherapy • general characteristics of antimicrobials • main mechanisms of antibacterial action • antibiotic resistance mechanisms and role of mobile genetic elements • public health issue

Chapter 3 Chapter 7 Chapter 39 Chapter 34 Chapter 39

Chapter 39

Chapter 39

Chapter 9 Chapter 16 Chapter 9 Chapter 16

Module 4: Introduction to fungal and protozoal diseases

L21: Introduction to protozoan diseases

L22: Arthropod-borne protozoan diseases L23: Helminth diseases L24: Introduction to mycology and fungal diseases

• • • • •

defining characteristics of protozoans taxonomy of protozoan parasites importance of parasitic diseases direct contact parasitic diseases examples water and food borne parasitic disease examples

• epidemiology, pathology, diagnosis and treatment of vector borne parasitic disease examples • malaria, leishmaniasis, sleeping sickness, Chagas disease • transmission, life-cycle overview and diseases • nematodes, trematodes, cestodes • fungal structures, functions and reproduction • cutaneous and subcutaneous mycoses

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Chapter 24 Chapter 40

Chapter 40

Not in Prescott Chapter 25 Chapter 40

L25: Systemic and opportunistic fungal diseases

• systemic mycoses • opportunistic mycoses

L26: Introduction to infectious diseases epidemiology

• basic epidemiology terms and concepts • emerging, re-emerging pathogens and disease outbreaks • public health surveillance and preventive measures • One Health

Chapter 40 Chapter 36

*Lecture material and slides may not have come directly from this textbook; however, the cited chapters will give you useful background reading in all cases.

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School of Biomedical Sciences The University of Western Australia M504, Perth WA 6009 Tel: +61 8 6457 4658 Email: [email protected] www.uwa.edu.au

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