Dr Al Sears Telomere Secrets Volume 1, Telomere Secrets Volume 2,Telomere Secrets Volume 3,Telomere Secrets Volume 4, Telomere Secrets Volume 5

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Dr. Sears’

Telomere

Secrets Volume 1:

Activate the Enzyme that Rebuilds Your Telomeres

© 2013 by Wellness Research & Consulting Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. Published by: Al Sears, MD 11903 Southern Blvd., Ste. 208 Royal Palm Beach, FL 33411 561-784-7852 www.AlSearsMD.com Dr. Al Sears wrote this report to provide information in regard to the subject matter covered. It is offered with the understanding that the publisher and the author are not liable for any misconception or misuse of the information provided. Every effort has been made to make this report as complete and accurate as possible. The purpose of this report is to educate. The author and the publisher shall have neither liability nor responsibility to any person or entity with respect to any loss, damage, or injury caused or alleged to be caused directly or indirectly by the information contained in this report. The information presented herein is in no way intended as a substitute for medical counseling or medical attention.

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Uniquely Qualified to Keep You Healthier For Life Dr. Al Sears, M.D. currently owns and operates a successful integrative medicine and anti-aging clinic in Royal Palm Beach, Florida, with over 25,000 patients. His cutting-edge therapies and reputation for solving some of the most difficult-to-diagnose cases attract patients from around the world. As a graduate of the University of South Florida College of Medicine, Dr. Sears scored in the 99th percentile on his MCAT and graduated with honors in Internal Medicine, Neurology, Psychiatry, and Physical Medicine. After entering private practice, Dr. Sears was one of the first to be board-certified in anti-aging medicine. As a pioneer in this new field of medicine, he is an avid researcher, published author, and enthusiastic lecturer. He is the first doctor licensed in the U.S. to administer TA-65, the most important breakthrough in anti-aging medicine today. Dr. Sears is board-certified as a clinical nutrition specialist and a member of the American College of Sports Medicine (ACSM), the American College for the Advancement in Medicine (ACAM), the American Medical Association (AMA), the Southern Medical Association (SMA), the American Academy of Anti-Aging Medicine (A4M), and the Herb Research Foundation, (HRF). Dr. Sears is also an ACE-certified fitness trainer. Dr. Sears currently writes and publishes the monthly e-Newsletter, Health Confidential, and daily email broadcast, Doctor’s House Call, and contributes to a host of other publications in the field. He has appeared on over 50 national radio programs, ABC News, CNN, and ESPN. Since 1999, Dr. Sears has published 14 books and over 100 reports on health and wellness with a readership of millions spread over 163 countries. In his first book, The T-Factor, King of Hormones, Dr. Sears perfected the use of natural and bio-identical testosterone boosters to help men restore the drive, ambition, muscle strength, vitality and sexual performance of their youth. Dr. Sears followed up with 12 Secrets to Virility, a full-blown strategy for male performance that includes his own patient-tested protocols for successfully dealing with men’s health concerns like fighting excess estrogen, protecting the prostate, eliminating fat gain and keeping a sharp mind and memory. In 2004, Dr. Sears was one of the first to fight against the conventional belief that cholesterol causes heart disease, proving that cholesterol is not the cause, but the part of the body that heart disease acts upon. In The Doctor’s Heart Cure, Dr. Sears offers an easy-to-follow solution that effectively eliminates your risk of heart disease, high blood pressure and stroke. In 2006, Dr. Sears shocked the fitness world by revealing the dangers of aerobics, “cardio” and long-distance running in his book, PACE: The 12-Minute Revolution. Expanding on the fitness principles in The Doctor’s Heart Cure, he developed a fast, simple solution to restore muscle strength, guard against heart attack and burn excess fat. Today, PACE is practiced by thousands of people worldwide. In 2010, Dr. Sears made history by bringing telomere biology to the general public. As the first U.S. doctor

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licensed to administer a groundbreaking DNA therapy that activates the gene that regulates telomerase, his breakthrough book Reset Your Biological Clock shows how anyone can preserve the energy of youth by controlling the length of your telomere, the true marker of aging. An avid lecturer, Dr. Sears regularly speaks at conferences sponsored by the American Academy of AntiAging Medicine (A4M), the American College for the Advancement of Medicine (ACAM), the Age Management Medicine Group (AMMG), and the Society for Anti-Aging, Aesthetic and Regenerative Medicine Malaysia (SAAARMM). As the founder and director of Wellness Research Foundation, a non-profit research organization, Dr. Sears has made it his life’s work to bring his patients the latest breakthroughs in natural therapies. As part of his ongoing research, Dr. Sears travels the world in search of herbs, novel cures and traditional remedies. Meeting with doctors and healers, Dr. Sears has brought back and revitalized much of the traditional knowledge considered endangered in today’s modern world.

••During an expedition to the Peruvian Andes, Dr. Sears brought back a nutrient-dense oil made from the Sacha Inchi nut, containing the highest plant source of heart and brain boosting omega-3 fatty acids.

••In India, Dr. Sears studied at the oldest existing school of Ayurvedic medicine, the ancient

Indian healing tradition, and was tutored by Ayurvedic doctors on the use of potent Indian herbs used to treat heart disease, cancer and Alzheimer’s disease.

••While trekking through the Amazon rainforest in Brazil, Dr. Sears lived among the native Ashaninka Indians, incorporating their ancient knowledge of healing herbs into his own nutritional supplement formulas.

••In Jamaica, Dr. Sears met with the last living healer from the ancient and forgotten lineage

known as the Maroons. Coming from West Africa 500 years ago, their knowledge was on the brink of extinction until Dr. Sears published a book showcasing their unique herbs and healing formulas.

••On the island of Bali, Dr. Sears had a meeting with the most famous of the ancient healers

known as “Balians,” – Ketut Leyir – and also met two of the country’s foremost herbalists. Dr. Sears is publishing a book showing how to use Balinese herbs and make unique healing mixtures for the skin and body.

With a life-long interest in botany, herbology, physiology and anthropology, Dr. Sears has a unique capacity to investigate the evidence behind the stories and claims of traditional medicine from native cultures around the world. By exposing the flaws of mainstream medicine and pioneering new solutions through innovative approaches to exercise, nutrition and aging, Dr. Sears continues to empower the lives of his patients and readers through his books, newsletters and regular media appearances.

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Dr. Sears’ Telomere Secrets: Volume 1: Activate the Enzyme that Rebuilds Your Telomeres I remember writing the word “telomere” on a piece of scratch paper. Underneath, I added, “This will change the world as we know it.” That was back in 1990, just moments after I finished reading an article in the journal Nature about a new technology that promised to turn everything we know about aging and disease on its ear. Today, I want to show you how I’m discovering the revolution is in full swing all around me. I no longer guess at how and why we age. I know EXACTLY how the mechanism of aging works... and how to influence it so that we maintain the power, strength and enthusiasm of youth for longer than anyone imagined possible. Finding this “cellular control switch” inside our cells and understanding how I can influence it to extend our “health span” is the greatest discovery of our time. I now have a true “age-reversing therapy,” and with it, the ability to slow the loss of our physical and mental powers. In many cases, I can EXTEND the time we have on this earth to feel young and vibrant. In this special report, I’ll show you what this discovery really means, the story behind the researchers who won the Nobel Prize for its discovery and how YOU can use a handful of simple nutrients to set this “control switch” to “perpetual youth.” I’ll also show you the science behind the magic and why researchers from the University of California at San Francisco to Harvard University all agree that this breakthrough will change life as we know it... forever.

I Now Understand the True Mechanism of Aging Over the past century, dozens of ideas, theories and hypotheses have made their way through the halls of universities and laboratories around the world. But as captivating as these ideas may have been at the time, I now know that all the factors I used to think of as “causes” of aging are merely the “consequences” of aging. Most of the so-called “causes” come from internal sources. In other words, the hormones, cells and sources of energy inside our bodies start to decline over time and cause the loss of energy, vitality and immunity we associate with aging. There’s “menopause” the hormonal changes that usher women into middle age, “adropause” or the loss of male sex hormones like testosterone in men that cause a loss of sex drive, ambition and muscular physique. There’s “somatopause” the loss of growth hormone that immediately saps your physical performance and adds pounds of fat around your middle, there’s “thyropause” the loss of thyroid hormones that throw off your metabolism and energy... and dozens of other “pauses” that rob you of your youth. There were also the ideas that focused on external causes of aging such as poor diet, stress, lack of exercise or physical challenges, predation, contamination of our air, water and food supply, as well as the new modern

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threat, the toxic “chemical body burden” that accumulates in your blood from the time we’re in the womb. But ALL these influences, whether internal or external all point to ONE FINAL PATHWAY that determines how and why you age, and that’s the shortening of the telomere. To better understand what this means... let’s take a look at what the “telomere,” or your “cellular control switch” really is.

Your Telomeres Tell Your Cells How Old They Are Deep within your DNA, located in the nucleus of each cell, are the building blocks or “blueprint” of every cell in your body. At the end of each strand of DNA is a little bit of genetic material called the telomere (tee-lo-mere).

The telomeres are the “protective tips” or “caps” at the ends of each strand of DNA. As a whole, your DNA contains the blueprint or program for EVERY cell in your body.

The telomere is the part of your chromosome that controls aging. And every time your cells divide, your telomeres get shorter. And when your telomeres finally run out, cell division stops and life comes to an end. But there’s more to it than that. As you age and your telomeres get shorter, your body produces cells that are older, weaker, and more decrepit. It’s programmed old age... complete with all the telltale problems that come with it. In fact, the shorter your telomeres, the “older” your body is, regardless of your actual age. In this way, your telomeres “tell” or instruct your cells how to behave based on how old they are. But when you slow the countdown, you may be able to extend your lifespan, and feel younger longer. First, there’s something even more remarkable about the telomere you need to know.

The Telomere is the “Director” of Your Life Movie Because telomere biology is an emerging science, there are researchers who suggest the telomere is merely an “end point” that signals the end of life when the telomere burns down to the end and cell division stops. I believe the telomere has a more powerful, more commanding role in how we live day-to-day and year-toyear. Playing the role “control switch” in your cells, the telomere serves as the “director” of the unfolding drama we call life. This control switch determines how old your cells act, what they’re capable of, and what their true potential is at EVERY moment of your life. Like a movie director, the telomere tells the cell what to look like, how to move and what to say. It literally gives your cells a complete set of instructions, like a script or screenplay, based on what act and scene of your “life movie” you’re currently acting in. And those instructions can change quickly if there’s a rapid loss of the telomere. But today we know we can influence the director of this movie.

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There are newly discovered telomerase activators you can take RIGHT NOW that don’t cost more than a few hundred dollars a month... and that’s if you take the best 9 or 10 that we know of. What’s more, you can get started without going through a lot of blood work or physical exams. Below is a list of the best nutrients that are clinically proven to activate telomerase, your “fountain of youth” enzyme.

Use These Newly Discovered Telomerase Activators To Activate Your “Fountain of Youth” Enzyme There are a lot of new terms that may take some getting used to, but here’s a quick recap of what you need to know:

••Telomere: These are the “caps” at the end of each chromosome. Your chromosomes are the

blueprints of life and are packed together in the nucleus, or center, of every one of your cells.

Every time your cells divide, the telomere gets a little bit shorter. When the telomere runs out, cell division stops and life comes to an end. I like to think of the telomere as your cellular control switch, because the length of your telomeres determines which part of your genome you express. By keeping longer telomeres, your control switch is set in the “younger” part of your genome, which means your body will create younger-looking and younger-acting cells.

••Telomerase: This is the enzyme that “rebuilds”

your telomeres. In our cells, this enzyme is “turned off.” That means there’s usually no way to stop the loss of your telomeres, or to rebuild them.

The telomerase enzyme was first discovered by Dr. Elizabeth Blackburn in 1984. Today, we are finding new ways to “turn on” this fountain of youth enzyme to prevent the shortening of the telomere and in many cases, lengthen it.

••TA-65®: This was the first compound ever

discovered that “flips the switch.” This molecule “turns on” your telomerase so you can extend the life of your telomeres and therefore your cells.

And here’s the REALLY good news...

This photo from NASA shows human chromosomes (in grey), capped by the telomeres, seen as the white dots at the ends.

••Newly Discovered Telomerase Activators:

There are a handful of nutrients that are proven to not only prevent the loss of the telomere, but to activate telomerase and rebuild the telomere.

Here are the best of these newly discovered activators:

Resveratrol: It’s probably no surprise this popular anti-aging nutrient can, according to new studies, “significantly increase telomerase activity.” By helping to “turn on” genes that promote longevity, and “turn off ” genes that

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promote disease, this new research confirms resveratrol’s role as a leading telomerase activator.1 By influencing the way genes are expressed, resveratrol has the ability to activate anti-aging genes called sirtuins. Sirtuins transmit signals to every cell in your body that literally cancel out the effects of aging. They bring the processes that lead cell death to a crawl, buying your body more time to repair the DNA damage that brings life to an end. Resveratrol is in the skin of grapes. It protects the grape from threats such as cold weather, UV radiation and microbes. The amount of resveratrol in wine differs. White wine is not made with the skins like red is – so white wine has little resveratrol. Red wines from colder regions have the most resveratrol. Drinking one or two glasses of red wine is one way to benefit from resveratrol. To get the maximum amount choose wines from Burgundy and Argentina’s Cafayate Valley. Most red wines from California and Australia will have lower amounts. If you’re not a fan of red wine, resveratrol is also in:

••Raisins ••Purple Grape Juice ••Peanuts ••Mulberries ••Eucalyptus Trees ••Japanese knot wood The problem lies in getting sufficient amounts of resveratrol. You’d need to drink 1,000 to 3,000 glasses of wine to experience the life extending benefits of resveratrol. Resveratrol supplements are a better option. They’re inexpensive and completely safe. You can take it any time of day, with or without food.You can find them in health food stores or on line. I recommend taking around 10 mg to 20 mg per day for telomerase activation.

Green Tea (EGCG): The extract of green tea, EGCG, has a powerful protective effect on telomeres. In a study published in the British Journal of Nutrition, the telomeres of green tea drinkers were about 0.46 kilobases longer. This average difference in the telomere length corresponds to, “approximately a difference of five years of life.” 2 The active ingredient in green tea is EGCG, which can prevent and repair cell damage. As a scavenger of free radicals, EGCG combats the effects of pollution, sunlight and smoking, which helps skin from wrinkling and aging. The best way to receive the benefits abundant in green tea – including the EGCG – is to start with whole tea leaves (sold in specialty tea stores) or with a tea bag. Most of the bottled green tea drinks contain additives like aspartame that counteract brewed green tea’s

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healing properties. I suggest you make your own to maximize the powerful, antioxidant-fighting benefits. You can also find ECGC supplements at your local health food store. I suggest taking 50 mg of ECGC daily.

N-Acetyl-Cysteine (NAC): This potent amino acid is a building block of your body’s primary antioxidant called glutathione (GSH) and has the ability to prevent the death of cells by activating the human telomerase gene, your “fountain of youth gene.” Just one of the many examples of how NAC protects your cells from early death is in your inner ear. Our military now treats soldiers with NAC during training to protect them from blast noise from gunfire and explosions.3 In fact, one study looked at military officers after shooting practice. The guns are incredibly loud. A roaring jet engine from a plane taking off a few feet above your head would be about 120 decibels. These officers were hearing gunfire that was up to 160 decibels. After the noise exposure, one group took NAC and one got no treatment. The NAC group had much better hearing. Not only that, but the unprotected group had damage to the inner ear structure that’s responsible for turning sound into nerve impulses so your brain can make sense of it. But the NAC group stayed completely normal and totally protected.4 To stimulate the activation of telomerase, I recommend a dose of 1,800 mg to 2,400 mg a day. NAC is available at your local nutrition and/or health food stores.

Alpha Tocopherol: The most well-known form of vitamin E, alpha tocopherol protects against telomere shortening by activating and restoring telomerase.5 That may explain why vitamin E can help prevent heart disease and even cancer. Research from Finland gave us with the first massive study proving that vitamin E prevents prostate cancer. Researchers monitored over 29,000 men for up to 8 years. They took either vitamin E or a placebo daily. The men taking the vitamin E had a 32% lower rate of prostate cancer. Also, these men had a 41% fewer deaths from prostate cancer than those men not taking vitamin E. The researchers believed that vitamin E prevented cancer in a several ways. By:

••Neutralizing free radicals in your body ••Protecting your cells from oxidation ••Aiding in cell membrane stability ••Stopping damaged cells from multiplying Today we know vitamin E’s primary protective mechanism comes from the telomere from being shortened, and by activating the enzyme that rebuilds your telomere, telomerase. The very best forms of vitamin E come straight from mother nature. You can find vitamin E in a wide variety of foods. The best of these includes:

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••Nuts ••Nut oils ••Seeds ••Apples ••Beef ••Seafood ••Avocados ••Spinach Sadly, the vast majority of Americans don’t consume nearly enough vitamin E. And, it would be very difficult to eat enough to get the amounts of vitamin E used in the studies. To get these amounts you’ll need to take vitamin E in supplement form. Fill your diet with foods rich in vitamin E. But in addition, I also recommend 400 IU of vitamin E daily.

Gamma Tocotrienol: One of the four lesser-known forms of vitamin E, gamma tocotrienol can, “modulate the length of the telomere possibly via telomerase.” During one study, telomere lengths were 16% longer than controls when exposed to gamma tocotrienol.6 Most people don’t know this, but there are eight forms of vitamin E: four tocopherols and four tocotrienols. While they’re all antioxidants, there are big differences. Tocotrienols help:

••Reduce cholesterol oxidation ••Maintain healthy triglyceride levels ••Support normal blood pressure levels Tocotrienols are hard to come by. You won’t find them in most foods. In fact, it’s almost impossible to get enough of them even if you do eat the few foods that contain them. For instance, palm oil is rich in tocotrienols. But who consumes a lot of palm oil? Even if you did, you’d have to drink a cup a day to get enough of the recommended amount. Annatto is one of the richest sources of tocotrienols in the world, but is also hard to come by. The problem with most vitamin E supplements is they contain none of the heart healthy tocotrienols and only ONE type of tocopherol. I recommend a supplement of “mixed tocotrienols,” as it is just about impossible to get gamma tocotrienol on its own. Look for at least 20 mg of mixed tocotrienols per dose.

L-Carnosine: L-carnosine can help you live longer, and you can’t get it from any other food source. Your body uses

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L-carnosine to repair tissues and clear away toxins. But here’s something else it can do that even I didn’t know until recently... It helps preserve your telomeres. By doing this, it extends the life cycle of your cells.7 I first read about carnosine’s anti-aging talents in a study done in Beijing. Researchers saw that cells grown with carnosine had healthier telomeres than cells grown without it. After a lot of digging and a little math, I discovered that the dose they used was extremely high. It would be about the same as taking 17.1 grams of carnosine. I don’t recommend that you take that much. You can get the benefits for your body at a lower dose. Carnosine is stored in a few places in your body, and your muscles and brain get the most of it. But when it comes to your blood, carnosine doesn’t stick around for very long. I recommend 1000 milligrams of carnosine every day to keep the levels in your blood high enough to make a difference. Grass-fed, pasture-raised meat is the best way to get carnosine from food. A typical 3.5-ounce serving of beef has about 124 to 220 milligrams of carnosine. When you eat red meat, carnosine can be detected in your blood for about five hours afterward. When you don’t eat it, you won’t have any carnosine in your blood at all. Take carnosine as a supplement if you can’t get enough by eating red meat, I recommend taking 500 milligrams twice a day instead of all at once. That way your body always has some on hand to use for protecting your telomeres, supporting your muscles, and encouraging tissue repair.

L-Arginine: A popular amino acid for improving blood flow, l-arginine increases telomerase activity by stimulating the production of nitric oxide (NO), the molecule that relaxes your blood vessels.8 The real star here is nitric oxide (NO). And the first step to more NO is a simple amino acid called l-arginine. Your body uses this amino acid to trigger the release of NO. Body builders have been using l-arginine for years. Taken before a workout, it gives them a “muscle pump” by getting more blood and oxygen to their muscles. Sometimes referred to as the “miracle molecule,” NO is a gas produced by a single layer of cells that line your blood vessels. When NO is released, it causes your blood vessels to relax and expand, sending a rush of oxygen through your body. This expansion of your blood vessels, and the increased flow of blood and oxygen that follows, is essential for life. You couldn’t live without it. And with new research showing NO increases telomerase activity, l-arginine is even more important. Fortunately, l-arginine is inexpensive and easy to find at just about any vitamin shop or health food store. I recommend 500 mg to 1,000 mg a day.

Vitamin C: We knew vitamin C prevented the loss of your telomeres, but we now have evidence that it increases telomerase activity in specific stem cells.9

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Your telomeres are very sensitive to oxidation. And as you know by now, the shorter your telomeres, the older your cells act and the more susceptible they are to becoming cancerous. The new, exciting discovery about vitamin C is that it’s very effective at slowing down this aging process. A Japanese study tested vitamin C’s effect on telomeres. It was found that raising the level of vitamin C in the cells could slow down the shortening of telomeres up to 62%. Another study found that skin cells treated with vitamin C kept their young firm shape because it slowed shortening of the cell DNA’s telomeres. The telomeres also suffered less damage in the presence of vitamin C.10 Vitamin C isn’t just “good for you.” It protects your DNA. And according to this new research, you should take at least 540 mg per day.

Vitamin D3: Famous for it’s ability to increase immune function and prevent cancer, vitamin D also activates telomerase. One very recent study showed vitamin D increased telomerase activity by 19.2%.11 Vitamin D may be the single most important nutrient in your body. Vitamin D helps:

••Boost your mood and mental performance ••Prevent prostate, breast, ovarian, and many other cancers ••Reduce your risk of skin cancer ••Prevent and treat bone diseases ••Prevent diabetes Vitamin D is used by every cell and keeps them healthy and functioning at their best, and it’s critical for your immune system. If you don’t have enough, some cells may end up damaged and diseased. To prevent cancer, your levels of vitamin D must be much higher than the 400 IU our government recommends. Based on this new data, I recommend taking at least 2,000 IU per day. You can also get vitamin D from Nature. The best sources include:

••Cod Liver Oil ••Herring ••Catfish ••Salmon, cooked ••Mackerel, cooked ••Sardines, canned in oil, drained ••Tuna, canned in oil 12

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Milk Thistle (Silymarin extract): This ancient, well-known herb is popular for detoxification but was recently discovered to activate telomerase. Researchers concluded, “silymarin increased telomerase activity 3-fold.”12 Milk thistle, also known as the plant Silybum marianum, is one of the best for clearing toxins from your blood and GI tract and helps restore liver function. Many ailments are related to toxin build-up. These toxins amass over time. This further interferes with the function of your liver.

I have been able to document its capacity to heal damaged livers by measuring serum liver enzymes. I recommend 200 mg in capsule form twice a day. There are no regular food sources for this herb. Look for dried extract with a minimum of 80% silymarin, the active ingredient for liver cleansing, and as we now know, telomerase activation.

Ginko Biloba: Originally known as a brain booster because it helps open up blood vessels to enhance circulation and oxygen delivery, there’s evidence that, “ginkgo biloba extract significantly increased telomerase activity,” and helps prevent the loss of the telomere in sensitive cells that line your blood vessels.13 While the research is unclear regarding how much ginko biloba effectively activates telomerase, I recommend keeping your daily dose between 40 mg and 80 mg and cycling every 4 to 6 weeks. In other words, do not take ginko continuously for the rest of your life. It will lose its effectiveness. Take it for 4 to 6 weeks, then stop. Wait for 4 to 6 weeks, then start the cycle again.

Folic Acid: This humble B vitamin is important for making the DNA found in your telomeres. A number of studies suggest folic acid stimulates the activation of telomerase.14 Folic acid is one of the B vitamins I prescribe to help stop the loss of your telomeres. And it’s one of five nutrients used to get rid of excess homocysteine that builds up in your blood stream when you’re antioxidant levels start to drop. Homocysteine is a damaging amino acid that triples the amount of telomere length lost during cell division. Fortunately, there are supplements you can take to lower your homocysteine in a very short time. This is the formula I recommend to my patients:

••Vitamin B12 – 500 mcg ••Folic Acid – 800 mcg ••Vitamin B6 – 25 mg ••Riboflavin (B2) – 25 mg ••TMG (trimethylglycine) – 500 mg

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But I want you to keep something in mind. The new research showing folic acid activates telomerase used a dose of 2 mg to 5 mg daily.

Acetyl L-Carnitine: This simple amino acid boost your brain’s level of Nerve Growth Factor by up to 100 times, which explains why this is a favorite brain booster. But studies suggest that acetyl l-carnitine activates the human telomerase gene through a chain reaction that starts with the increase of Nerve Growth Factor.15 L-carnitine is the utility system for your vital organs. Your heart uses it in bulk to keep blood pumping. Your brain burns through it at lightning speed. Your liver and kidneys require it to work properly. Your sex organs thrive on it for optimum function. Plus, 95 percent of all cells in your body rely on l-carnitine to melt fat away. That’s because l-carnitine shuttles fat into your cells where it’s used for energy, instead of being stored as fat. The problem is your body can’t make enough on its own. When scientists looked at levels of this vital nutrient in muscle tissue across a range of age groups, they found a “drastic reduction,” in older folks.16 Why? Because these days, you can’t get enough of it from Nature’s richest source: red meat. (The word “carnitine” comes from “carnus,” the Latin word for meat.) Here are good sources of l-carnitine based on a single 3.5 oz serving:

••Beef Steak, 95 mg ••Ground Beef, 94 mg ••Pork, 27.7 mg ••Bacon, 23.3 mg You can also supplement your diet with l-carnitine. While the research on how much you need to activate telomerase is still being determined, I recommend a daily amount of 1000 mg. I give my patients the liquid form of l-carnitine. It’s the most absorbable. The powders tend to clump and the capsules may contain unwanted fillers and binders that may inhibit its absorption. Also, many l-carnitine capsules use the synthetic “D form” of l-carnitine, which interferes with the natural action of l-carnitine. Make sure you choose a supplement that uses naturally occurring l-carnitine. Plus, the liquid form is easy to use. The formula I give my patients requires just one tablespoon a day.

Reference: 1 Wang XB, Zhu L, Huang J, Yin YG, Kong XQ, Rong QF, Shi AW, Cao KJ. Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells. Chin Med J (Engl). 2011 Dec;124(24):4310-5. 2 Chjan R, Woo J, Suen E, Leung, Tang N. Chinese tea consumption is associated with longer telomere length in elderly Chinese men. Br. J Nutr. 2010 Jan;103(1):107-13. Epub 2009 Aug 12.  3 Ewert D, Lu J, Li W, Du X, Floyd R, Kopke R. “Antioxidant treatment reduces blast-induced cochlear damage and hearing loss.” Hear

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Res. 2012 Mar;285(1-2):29-39. 4 Lindblad A, Rosenhall U, Olofsson A, Hagerman B. “The efficacy of N-acetylcysteine to protect the human cochlea from subclinical hearing loss…” Noise Health. 2011 Nov-Dec;13(55):392-401. 5 Makpol S, Zainuddin A, Rahim NA, Yusof YA, Ngah WZ. Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals. Planta Med. 2010 Jun;76(9):869-75. 6 Suzana Makpol, et al. Gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. Oxidative Medicine and Cellular Longevity. 3(1); Jan-Feb 2010. 7 Shao L, Li QH, Tan Z, “L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts,” Biochem Biophys Res Commun. 2004 Nov 12;324(2):931-6. 8 Scalera F, Martens-Lobenhoffer J, Täger M, Bukowska A, Lendeckel U, Bode-Böger SM. Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging. Biochem Biophys Res Commun. 2006 Jul 7;345(3):1075-82 9 Wei F, Qu C, Song T, Ding G, Fan Z, Liu D, Liu Y, Zhang C, Shi S, Wang S. Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity. J Cell Physiol. 2012 Sep;227(9):3216-24. 10 Yokoo S, Furumoto K, Hiyama E, Miwa N. “Slow-down of age-dependent telomere shortening is executed … by anti-oxidative effects of pro-vitamin C.” J Cell Biochem. 2004 Oct 15;93(3):588-97. 11 Zhu H, Guo D, Li K, Pedersen-White J, Stallmann-Jorgensen IS, Huang Y, Parikh S, Liu K, Dong Y. Increased telomerase activity and vitamin D supplementation in overweight African Americans. Int J Obes (Lond). 2012 Jun;36(6):805-9. 12 Parzonko A, Naruszewicz M. Silymarin inhibits endothelial progenitor cells’ senescence and protects against the antiproliferative activity of rapamycin: preliminary study. J Cardiovasc Pharmacol. 2010 Dec;56(6):610-8. 13 Dong, Xie Xu, PhD; et al., Ginko Biloba reduces endothelial progenitor cell senescence through augmentation of Telomerase Activity. Journal of Cardiovascular Pharmacology. Feb 2007, vol.49, issue 2, pp. 111-115. 14 Paul L, et al. Telomere length in peripheral blood mononuclear cells is associated with folate status in men. J Nutr. 2009 Jul;139(7):1273-8. 15 Taglialatela G. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp Gerontol. 1994 Jan-Feb;29(1):55-66. 16 Costell et al. “Age-dependent decrease of carnitine content in muscle of mice and humans.” Biochemical and Biophysical Research Communications. 1989. 161(3):1135-43.

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Dr. Sears’

Telomere

Secrets Volume 2:

Upgrade to a Smarter, Faster Brain

© 2013 by Wellness Research & Consulting Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. Published by: Al Sears, MD 11903 Southern Blvd., Ste. 208 Royal Palm Beach, FL 33411 561-784-7852 www.AlSearsMD.com Dr. Al Sears wrote this report to provide information in regard to the subject matter covered. It is offered with the understanding that the publisher and the author are not liable for any misconception or misuse of the information provided. Every effort has been made to make this report as complete and accurate as possible. The purpose of this report is to educate. The author and the publisher shall have neither liability nor responsibility to any person or entity with respect to any loss, damage, or injury caused or alleged to be caused directly or indirectly by the information contained in this report. The information presented herein is in no way intended as a substitute for medical counseling or medical attention.

2

www.AlSearsMD.com

Uniquely Qualified to Keep You Healthier For Life Dr. Al Sears, M.D. currently owns and operates a successful integrative medicine and anti-aging clinic in Royal Palm Beach, Florida, with over 25,000 patients. His cutting-edge therapies and reputation for solving some of the most difficult-to-diagnose cases attract patients from around the world. As a graduate of the University of South Florida College of Medicine, Dr. Sears scored in the 99th percentile on his MCAT and graduated with honors in Internal Medicine, Neurology, Psychiatry, and Physical Medicine. After entering private practice, Dr. Sears was one of the first to be board-certified in anti-aging medicine. As a pioneer in this new field of medicine, he is an avid researcher, published author, and enthusiastic lecturer. He is the first doctor licensed in the U.S. to administer TA-65, the most important breakthrough in anti-aging medicine today. Dr. Sears is board-certified as a clinical nutrition specialist and a member of the American College of Sports Medicine (ACSM), the American College for the Advancement in Medicine (ACAM), the American Medical Association (AMA), the Southern Medical Association (SMA), the American Academy of Anti-Aging Medicine (A4M), and the Herb Research Foundation, (HRF). Dr. Sears is also an ACE-certified fitness trainer. Dr. Sears currently writes and publishes the monthly e-Newsletter, Health Confidential, and daily email broadcast, Doctor’s House Call, and contributes to a host of other publications in the field. He has appeared on over 50 national radio programs, ABC News, CNN, and ESPN. Since 1999, Dr. Sears has published 14 books and over 100 reports on health and wellness with a readership of millions spread over 163 countries. In his first book, The T-Factor, King of Hormones, Dr. Sears perfected the use of natural and bio-identical testosterone boosters to help men restore the drive, ambition, muscle strength, vitality and sexual performance of their youth. Dr. Sears followed up with 12 Secrets to Virility, a full-blown strategy for male performance that includes his own patient-tested protocols for successfully dealing with men’s health concerns like fighting excess estrogen, protecting the prostate, eliminating fat gain and keeping a sharp mind and memory. In 2004, Dr. Sears was one of the first to fight against the conventional belief that cholesterol causes heart disease, proving that cholesterol is not the cause, but the part of the body that heart disease acts upon. In The Doctor’s Heart Cure, Dr. Sears offers an easy-to-follow solution that effectively eliminates your risk of heart disease, high blood pressure and stroke. In 2006, Dr. Sears shocked the fitness world by revealing the dangers of aerobics, “cardio” and long-distance running in his book, PACE: The 12-Minute Revolution. Expanding on the fitness principles in The Doctor’s Heart Cure, he developed a fast, simple solution to restore muscle strength, guard against heart attack and burn excess fat. Today, PACE is practiced by thousands of people worldwide. In 2010, Dr. Sears made history by bringing telomere biology to the general public. As the first U.S. doctor

Dr. Sears’ Telomere Secrets: Volume 1: Upgrade to a Smarter, Fast Brain

3

licensed to administer a groundbreaking DNA therapy that activates the gene that regulates telomerase, his breakthrough book Reset Your Biological Clock shows how anyone can preserve the energy of youth by controlling the length of your telomere, the true marker of aging. An avid lecturer, Dr. Sears regularly speaks at conferences sponsored by the American Academy of AntiAging Medicine (A4M), the American College for the Advancement of Medicine (ACAM), the Age Management Medicine Group (AMMG), and the Society for Anti-Aging, Aesthetic and Regenerative Medicine Malaysia (SAAARMM). As the founder and director of Wellness Research Foundation, a non-profit research organization, Dr. Sears has made it his life’s work to bring his patients the latest breakthroughs in natural therapies. As part of his ongoing research, Dr. Sears travels the world in search of herbs, novel cures and traditional remedies. Meeting with doctors and healers, Dr. Sears has brought back and revitalized much of the traditional knowledge considered endangered in today’s modern world.

••During an expedition to the Peruvian Andes, Dr. Sears brought back a nutrient-dense oil made from the Sacha Inchi nut, containing the highest plant source of heart and brain boosting omega-3 fatty acids.

••In India, Dr. Sears studied at the oldest existing school of Ayurvedic medicine, the ancient

Indian healing tradition, and was tutored by Ayurvedic doctors on the use of potent Indian herbs used to treat heart disease, cancer and Alzheimer’s disease.

••While trekking through the Amazon rainforest in Brazil, Dr. Sears lived among the native Ashaninka Indians, incorporating their ancient knowledge of healing herbs into his own nutritional supplement formulas.

••In Jamaica, Dr. Sears met with the last living healer from the ancient and forgotten lineage

known as the Maroons. Coming from West Africa 500 years ago, their knowledge was on the brink of extinction until Dr. Sears published a book showcasing their unique herbs and healing formulas.

••On the island of Bali, Dr. Sears had a meeting with the most famous of the ancient healers

known as “Balians,” – Ketut Leyir – and also met two of the country’s foremost herbalists. Dr. Sears is publishing a book showing how to use Balinese herbs and make unique healing mixtures for the skin and body.

With a life-long interest in botany, herbology, physiology and anthropology, Dr. Sears has a unique capacity to investigate the evidence behind the stories and claims of traditional medicine from native cultures around the world. By exposing the flaws of mainstream medicine and pioneering new solutions through innovative approaches to exercise, nutrition and aging, Dr. Sears continues to empower the lives of his patients and readers through his books, newsletters and regular media appearances.

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Dr. Sears’ Telomere Secrets: Volume 2: Upgrade to a Smarter, Faster Brain “It was akin to a Ponce de León effect…” Referring to the Spanish explorer who sought the mythical Fountain of Youth, Dr. Ronald DePinho revealed the details of his groundbreaking experiment in the Harvard Gazette.1 “When we flipped the telomerase switch on and looked a month later, the brains had largely returned to normal.” As a professor of genetics from Harvard Medical School and the director of applied cancer science at the Boston-based Dana-Farber Cancer Institute, Dr. Ronald DePinho was thrust into the limelight when the nearmiraculous results of his therapy gave new life to the aging brains of the animals in his lab. Restoring an old, shrunken brain to normal size would have been headline news all on its own. But there was more to the story. Dr. DePinho’s team of researchers discovered these rejuvenated brains gave birth to new nerve cells, developed new layers of the protective myelin sheath that surrounds nerve cells, and awakened slumbering brain stem cells so they could produce new neurons. In other words, Dr. DePinho’s therapy transformed faulty, aging brains into youthful, high-performing brains you might expect to find in a teenager. What caused this remarkable reversal of aging? Telomerase. It’s the enzyme that helps you rebuild the biological clocks at the end of your DNA called telomeres. Research into telomeres and how telomerase works is so revolutionary, it won the Nobel Prize for medicine in 2009. Today, I’m going to show you how to tap the remarkable power of your telomeres and the age-reversing enzyme that helps maintain them. That means you can use this very-same technology to restore and revive your own brain. In this special report I’ll show you how.

Regenerate Your Brain Cells with This Revolutionary Technology At the end of each strand of DNA is a little bit of genetic material called the telomere (tee-lo-mere). Telomeres are the “time keepers” attached to every strand of your DNA. Each time your cells divide, your telomeres get shorter. When your telomeres run down, cell division stops and your life ends. By slowing down the loss of your telomeres, you not only extend your brainpower, you stay younger longer. That’s what I do for my patients. And it’s important you know how this works.

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As the telomere gets shorter, your body produces cells that are older, weaker and more decrepit. This speeding up of telomere loss actually causes your body to transcribe an older, more dysfunctional part of your genome. That means your body becomes weaker, more frail and open to all the pitfalls of aging. It’s programmed old age for your brain… complete with all the telltale problems like memory loss, dementia and Alzheimer’s. In fact, the shorter your telomeres, the “older” your brain is, regardless of your actual age. In this way, your telomeres “tell” or instruct your brain cells how to behave based on how old they are. But when you switch on telomerase and make telomeres longer, like Dr. DePinho did, you regenerate your brain cells… regardless of how old you are.

The telomeres are the “protective tips” or “caps” at the ends of each strand of DNA. As a whole, your DNA contains the blueprint or program for EVERY cell in your body.

Just have a look at these study results.

Aging, Shrunken Brains Return to Normal Size When Dr. DePinho turned on the enzyme telomerase, the aging brains in the old mice returned to normal size.2 Check out these pictures. The brain on the left is taken from the group of old mice. The “brain shrinkage,” which happens naturally as you get older is clear to see. The brain on the left is clearly smaller, more narrow and weighs less. The brain on the right is from the same group of old mice… but this one was revived and restored by Dr. DePinho’s telomerase therapy. You can see how the brain on the right looks fuller and more robust. It weighs more, too. Here’s something else… the aging brains that Dr. DePinho restored had a new, heavier layer of a very important covering known as the “myelin sheath.” This insulating, protective cover surrounds the nerve cells in your brain and helps shuttle the electrical impulses your brain cells use to communicate with each other.

The smaller, “shrunken” brain on the left shows the loss of size that comes with age… the brain on the right was restored to normal size by “switching on” telomerase.

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You may have heard of the myelin sheath. Not only does it get thinner and more vulnerable as you age, it’s also the target of the amyloid-beta plaques that build up in Alzheimer’s patients. But miraculously, the myelin sheaths in the mice

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revived by Dr. DePinho, grew a new, heavier layer of this critical insulation. Here are the pictures.

The picture on the left shows a thin, narrow band where the myelin sheath has deteriorated with age. The photo on the right shows how the same myelin sheath has been restored to its full, youthful size.

In the picture on the left, you can see a very thin layer of grey that surrounds the nerve cell. This is the narrow myelin sheath in a nerve cell of one of the old mice. By contrast, you can see the thicker, heavier myelin sheath in the photo on the right. This shows you how the protective covering was fully restored after the telomeres in these rejuvenated mice became longer. Dr. DePinho noticed other changes, too. To test whether their newly-restored brains gave the mice new functional ability, researchers set up a maze to see if the mice would avoid a certain area when they detected the scent of a predator or a foul smell. Remarkably, these mice regained their sense of smell. When these mice were still “old,” their olfactory nerve cells had atrophied and they had lost their survival skills. But once Dr. DePinho restored their brain function, their nerve centers regenerated and they were able to negotiate the maze with ease. Even their memories and overall awareness improved. Now keep in mind, NEVER in the course of human history has anyone accomplished something even close to this. Previously, only in science fiction novels could you hope to resurrect dead brain cells. In the real world, it was pure fantasy. Today, this “miraculous” event is not only doable, it’s something you can actively pursue yourself. Given the right nutrients, you can start the process of regenerating your aging brain. For the first time, you have the potential to avoid the painful and debilitating loss of cognitive function by restoring the youthful characteristics of your own brain. And that’s good news, because you need to something…

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Shorter Telomeres are the Real Culprit Behind “Senior Moments” When your telomeres shorten, it causes the next generation of cells to be weaker, more vulnerable and more decrepit. And these older brain cells make you a prime candidate for all of those “senior moments” that come from memory loss, lack of concentration and muddled focus. And that’s not all… Studies published in respected journals like Annals of Neurology and Neurobiology of Aging show shorter telomeres are connected to some of the scariest age-related brain concerns like stroke, dementia and Alzheimer’s.3 4 5 But this decline in your ability to think, plan, strategize and remember, is NOT unavoidable. What doctors simply call “part of the aging process,” is really caused by shortening telomeres. And as you’ll see, telomeres can be influenced. You can slow their loss, and even lengthen them. Later in this report I’ll show you how. First, I want you to show you how this loss of brain power comes in three primary forms.

The 3 Enemies Zapping Your Brain Power As you age, your brain comes up against 3 major problems… all of which, are caused by shrinking telomeres.

••Your brain shrinks, impairing neurons and dulling connections between neurons.

••Levels of neurotransmitters decline, slowing, marring and reducing messages.

••Brain circulation decreases, and oxygen delivery drops.

It’s true… just like the old mice in Dr. DePinho’s experiment, your brain shrinks as you grow older. What’s more, research has shown that the problem is worse in men. The shrinking starts in adulthood. Researchers believe that the average brain shrinks 2% per decade. This means that at 80, your brain will be 12% smaller than at 20.6

By the time you’re 80, you’ve lost almost 15% of your total brain volume!

Another side effect of aging is the reduction of neurotransmitters in the brain. The two main neurotransmitters that decrease are acetylcholine and dopamine. These two chemicals are crucial for neuron communication. A lack of these chemicals causes messages to travel slowly, to break, or to stop traveling all together. The brain also loses some blood circulation as it ages. Blood brings nourishment to cells, and keeps the cells functioning. Without good circulation, your brain works less effectively.

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But here’s the good news: You can reverse the loss… and in many cases you can restore youthful brain function. Here’s the first step.

Nourish Your Aging Brain with a Limitless Number of New Brain Cells Decades ago, we were taught that your brain has a “set” number of brain cells. Remember hearing that once your brain cells died, that was it? It made it sound like your brain was in a constant state of degeneration. And that’s true in part. But here’s the difference: Today, we know that you CAN grow new brain cells… AND new neural networks that ramp up your brain power no matter how old you are. When you activate the enzyme telomerase, and add length to your shortening telomeres, it kicks your brain into a growth cycle that creates new brain cells through a process called neurogenesis. You see, your brain already has a population of neural stem cells. These “progenitor cells” can differentiate into brain neurons. In turn, these new brain cells create new networks by using neurites, the “branches” that stretch out and connect with other brain cells. But these stem cells need to be “activated.” And there’s a simple amino acid that’s not only a proven telomerase activator, it stimulates the process of neurogenesis by building new neural networks in your brain. Here’s how it works.

Sharpen Your Mental Edge with This Overlooked Brain Booster One of the most effective nutrients for rebuilding your telomeres and boosting your brain power is ALC. Studies suggest that ALC activates the human telomerase gene through a chain reaction that starts with the increase of Nerve Growth Factor.7 In just a moment, I’ll explain why Nerve Growth Factor is so important and how it can help create a younger, faster, more responsive brain. First, I want to show you why this particular amino acid is critical for keeping your mental edge. ALC is the utility system for your vital organs. Your heart uses it in bulk to keep blood pumping. Your brain burns through it at lightning speed. Your liver and kidneys require it to work properly. Your sex organs thrive on it for optimum function. Plus, 95 percent of all cells in your body rely on ALC to melt fat away. That’s because ALC shuttles fat into your cells where it’s used for energy, instead of being stored as fat. The problem is your body can’t make enough on its own. When

The chemical structure of acetyl l-carnitine: Taken daily, ALC can rebuild and regrow your aging brain.

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scientists looked at levels of this vital nutrient in muscle tissue across a range of age groups, they found a “drastic reduction,” in older folks.8 ALC stands for acetyl-L-carnitine. You won’t hear about this high-octane IQ fuel from most doctors. But it’s the key to brainpower. Studies show ALC keeps the mind from slowing down as time goes by. In fact it shores up your ability to recall words and names, follow what others are saying, and think and reason clearly. You’ll never have to worry about those “senior moments.” That’s because ALC ramps up production of a brain chemical called acetylcholine. This is a neurotransmitter that helps your brain relay signals between the neurons responsible for cognitive thought, focus, and memory. Your brain needs more and more acetylcholine as it ages, but can’t make more of it on its own. ALC makes up the difference, keeping those neurons firing literally at the speed of light. As I mentioned, poor blood circulation is another reason your thinking can get fuzzy with time. Your brain cells aren’t getting enough oxygen. Clinical evidence has shown that ALC keeps your brain’s cellular engines powered up in spite of decreased blood flow.9 It’s also a potent antioxidant. You’ve heard about free radicals. They cause damage by latching on to healthy cells, disrupting their natural functioning, changing their DNA, and even killing them. It’s a little-known fact, but free radical damage lies behind a lot of the gradual loss of brainpower that comes with aging. High-energy cells throw off a lot of free radicals. Because they use so much energy, your brain cells are particularly vulnerable. ALC puts the brakes on free radical activity. It boosts production of adenosine triphosphate (ATP), the basic fuel every cell in your body needs to make and transport energy.10 Higher levels of ATP boost your metabolism at the cellular level and can hel you to lose weight. It also literally reverses the age-related cell damage that can lead to brain fog. It even works in people who’ve already shown signs of senility or Alzheimer’s.

Your brain and nervous system are made up of nerve cells. The dendrites and axons are both forms of neurites, the “branches” that connect to other nerve cells. ALC works by regrowing nerve cells and forming new neural networks.

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The science proves it. Researchers recently looked at the effects of ALC in people with mild cognitive impairment and even early-stage Alzheimer’s disease. With as little as 1.5 to 3 grams per day, they showed significantly improved brain function across the board after three months.11

www.AlSearsMD.com

As if that weren’t enough, ALC boasts a long list of health benefits that go far beyond the brain. It’s been shown to ramp up male performance and slow nerve damage in diabetics.12 13 There’s even evidence that ALC can re-grow nerve cells.14 That’s because ALC helps slow the loss, and restore the function of Nerve Growth Factor (NGF)… a powerful protein that controls the growth and maintenance of your brian’s neurons. As your telomeres get shorter, there’s a decline both in the production of NGF and the number of NGF receptors you have in your brain cells. And this decline leads to a drop in brain performance and opens you up to memory loss and dementia. That’s why those studies I mentioned earlier found a connection between short telomeres and memory problems, dementia, stroke and Alzheimer’s. Even more impressive, ALC boosts neurite growth an incredible 100 TIMES MORE than NGF alone.15 As we discussed, neurites are those “branches” that extend from the middle of the neuron and connect with other brain cells to form networks. These neural networks are the key to a fast brain and alert mental state. The more networks you have and the faster these electrical impulses fire between cells, the clearer you can think and the better you remember. I recommend at least 1,000 milligrams per day. And if you’re feeling like you have memory concerns, or worse, you can safely take 3,000 mg a day. Think of it this way: When your telomeres get shorter, it cuts off production of NGF and your overall brain power starts to tank. ALC switches on telomerase, which rebuilds your telomeres… which in turn, reactivates NGF and a host of other performance-enhancing nutrients and enzymes, which fire up abilities you enjoyed when you were younger… but thought were gone forever. So remember… All of these brain-boosting changes are triggered by ALC’s ability to influence your telomeres. The telomere is at the heart of your brain’s power and ability to function. At the end of the day, your telomeres have absolute control over how healthy your brain cells are, and how well they function. Telomerase activators, like ALC, rebuild your telomeres and protect them from the accelerated loss that makes you grow old before your time. By activating telomerase, you have the opportunity to produce younger cells… even as you get older. Reference: 1 Richard Saltus, “Partial reversal of aging achieved in mice: Control of telomerase gene appears to control process,” Dana-Farber Cancer Institute. Sunday, November 28, 2010. Published in the Harvard Gazette: http://news.harvard.edu/gazette/story/2010/11/ partial-reversal-of-aging-achieved-in-mice/ 2 Horner J, Maratos-Flier E, Depinho R, et. al. “Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.” Nature. 2011 Jan 6;469(7328):102-6. 3 Honig LS, Schupf N, Lee JH, Tang MX, Mayeux R. Shorter telomeres are associated with mortality in those with APOE epsilon4 and dementia. Ann Neurol 2006; 60: 181–87.

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4 Panossian LA, Porter VR, Valenzuela HF, et al. Telomere shortening in T cells correlates with Alzheimer’s disease status. Neurobiol Aging 2003; 24: 77–84. 5 Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. 6 American Foundation for Aging Research: Neurobiology of Aging Information “What Physical Changes Happen to the Brain?” www.infoaging.com 7 Taglialatela G. Acetyl-L-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp Gerontol. 1994 Jan-Feb;29(1):55-66. 8 Costell et al. “Age-dependent decrease of carnitine content in muscle of mice and humans.” Biochemical and Biophysical Research Communications. 1989. 161(3):1135-43. 9 Calvani et al. “Attenuation by acetyl-l-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion.” International Journal of Tissue Reactions. 1992. 21(1):1-6. 10 Shigenaga et al. “Oxidative damage and mitochondrial decay in aging.” Proceedings of the National Academy of Sciences. 1994. 11 Montgomery et al. “Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer’s disease.” International Clinical Psychopharmacology. 2003. 18(2):61-71. 12 Giammuso et al. “Improved pallesthetic sensitivity of pudendal nerve in impotent diabetic patients treated with acetyl-L-carnitine.” Acta Urologica Italica (Italy). 1996. 10(3):185-187. 13 Gorio et al. “Peptide alterations in automatic diabetic neuropathy prevented by acetyl-L-carnitine.” International Journal of Clinical Pharmacological Research. 1992. 12:(5-6):225-230. 14 Taglialatela et al. “Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor.” Developmental Brain Research. 1991. 59(2):221-30. 15 Tagliatatela G, Angelucci L, Ramacci MT, et al. “Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor.” Brain Res Dev Brain Res. 1991 Apr 24;59(2):221-30.

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www.AlSearsMD.com

Dr. Sears’

Telomere

Secrets Volume 3:

Rejuvenate Your Aging Heart

© 2013 by Wellness Research & Consulting Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. Published by: Al Sears, MD 11903 Southern Blvd., Ste. 208 Royal Palm Beach, FL 33411 561-784-7852 www.AlSearsMD.com Dr. Al Sears wrote this report to provide information in regard to the subject matter covered. It is offered with the understanding that the publisher and the author are not liable for any misconception or misuse of the information provided. Every effort has been made to make this report as complete and accurate as possible. The purpose of this report is to educate. The author and the publisher shall have neither liability nor responsibility to any person or entity with respect to any loss, damage, or injury caused or alleged to be caused directly or indirectly by the information contained in this report. The information presented herein is in no way intended as a substitute for medical counseling or medical attention.

2

www.AlSearsMD.com

Uniquely Qualified to Keep You Healthier For Life Dr. Al Sears, M.D. currently owns and operates a successful integrative medicine and anti-aging clinic in Royal Palm Beach, Florida, with over 25,000 patients. His cutting-edge therapies and reputation for solving some of the most difficult-to-diagnose cases attract patients from around the world. As a graduate of the University of South Florida College of Medicine, Dr. Sears scored in the 99th percentile on his MCAT and graduated with honors in Internal Medicine, Neurology, Psychiatry, and Physical Medicine. After entering private practice, Dr. Sears was one of the first to be board-certified in anti-aging medicine. As a pioneer in this new field of medicine, he is an avid researcher, published author, and enthusiastic lecturer. He is the first doctor licensed in the U.S. to administer TA-65, the most important breakthrough in anti-aging medicine today. Dr. Sears is board-certified as a clinical nutrition specialist and a member of the American College of Sports Medicine (ACSM), the American College for the Advancement in Medicine (ACAM), the American Medical Association (AMA), the Southern Medical Association (SMA), the American Academy of Anti-Aging Medicine (A4M), and the Herb Research Foundation, (HRF). Dr. Sears is also an ACE-certified fitness trainer. Dr. Sears currently writes and publishes the monthly e-Newsletter, Health Confidential, and daily email broadcast, Doctor’s House Call, and contributes to a host of other publications in the field. He has appeared on over 50 national radio programs, ABC News, CNN, and ESPN. Since 1999, Dr. Sears has published 14 books and over 100 reports on health and wellness with a readership of millions spread over 163 countries. In his first book, The T-Factor, King of Hormones, Dr. Sears perfected the use of natural and bio-identical testosterone boosters to help men restore the drive, ambition, muscle strength, vitality and sexual performance of their youth. Dr. Sears followed up with 12 Secrets to Virility, a full-blown strategy for male performance that includes his own patient-tested protocols for successfully dealing with men’s health concerns like fighting excess estrogen, protecting the prostate, eliminating fat gain and keeping a sharp mind and memory. In 2004, Dr. Sears was one of the first to fight against the conventional belief that cholesterol causes heart disease, proving that cholesterol is not the cause, but the part of the body that heart disease acts upon. In The Doctor’s Heart Cure, Dr. Sears offers an easy-to-follow solution that effectively eliminates your risk of heart disease, high blood pressure and stroke. In 2006, Dr. Sears shocked the fitness world by revealing the dangers of aerobics, “cardio” and long-distance running in his book, PACE: The 12-Minute Revolution. Expanding on the fitness principles in The Doctor’s Heart Cure, he developed a fast, simple solution to restore muscle strength, guard against heart attack and burn excess fat. Today, PACE is practiced by thousands of people worldwide. In 2010, Dr. Sears made history by bringing telomere biology to the general public. As the first U.S. doctor

Dr. Sears’ Telomere Secrets: Volume 3: Rejuvenate Your Aging Heart

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licensed to administer a groundbreaking DNA therapy that activates the gene that regulates telomerase, his breakthrough book Reset Your Biological Clock shows how anyone can preserve the energy of youth by controlling the length of your telomere, the true marker of aging. An avid lecturer, Dr. Sears regularly speaks at conferences sponsored by the American Academy of AntiAging Medicine (A4M), the American College for the Advancement of Medicine (ACAM), the Age Management Medicine Group (AMMG), and the Society for Anti-Aging, Aesthetic and Regenerative Medicine Malaysia (SAAARMM). As the founder and director of Wellness Research Foundation, a non-profit research organization, Dr. Sears has made it his life’s work to bring his patients the latest breakthroughs in natural therapies. As part of his ongoing research, Dr. Sears travels the world in search of herbs, novel cures and traditional remedies. Meeting with doctors and healers, Dr. Sears has brought back and revitalized much of the traditional knowledge considered endangered in today’s modern world.

••During an expedition to the Peruvian Andes, Dr. Sears brought back a nutrient-dense oil made from the Sacha Inchi nut, containing the highest plant source of heart and brain boosting omega-3 fatty acids.

••In India, Dr. Sears studied at the oldest existing school of Ayurvedic medicine, the ancient

Indian healing tradition, and was tutored by Ayurvedic doctors on the use of potent Indian herbs used to treat heart disease, cancer and Alzheimer’s disease.

••While trekking through the Amazon rainforest in Brazil, Dr. Sears lived among the native Ashaninka Indians, incorporating their ancient knowledge of healing herbs into his own nutritional supplement formulas.

••In Jamaica, Dr. Sears met with the last living healer from the ancient and forgotten lineage

known as the Maroons. Coming from West Africa 500 years ago, their knowledge was on the brink of extinction until Dr. Sears published a book showcasing their unique herbs and healing formulas.

••On the island of Bali, Dr. Sears had a meeting with the most famous of the ancient healers

known as “Balians,” – Ketut Leyir – and also met two of the country’s foremost herbalists. Dr. Sears is publishing a book showing how to use Balinese herbs and make unique healing mixtures for the skin and body.

With a life-long interest in botany, herbology, physiology and anthropology, Dr. Sears has a unique capacity to investigate the evidence behind the stories and claims of traditional medicine from native cultures around the world. By exposing the flaws of mainstream medicine and pioneering new solutions through innovative approaches to exercise, nutrition and aging, Dr. Sears continues to empower the lives of his patients and readers through his books, newsletters and regular media appearances.

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Dr. Sears’ Telomere Secrets: Volume 3: Rejuvenate Your Aging Heart When your heart weakens, it’s painfully obvious. It may be one of the most noticeable changes associated with aging. Your body only has one way to get oxygen to your 75 trillion cells, and that’s through a fist-sized, muscular pump called your heart. And when your heart loses its pumping power, you lose power to EVERY cell in your body. When that happens, every cell, organ and tissue in your body loses energy. Your performance drops system wide… and you see that in every move you make. Your capacity to work, play, perform and achieve goes into a tailspin. Even your ability to get out of bed is jeopardized. All because your heart can no longer get enough oxygen to your cells. While this may sound like a typical side effect of aging, it’s not inevitable. In fact, new studies tell us your heart has a single “master mechanism” that decides how much energy your heart can hold onto as it gets older.

The “Cellular Secret” that Energizes Your Heart Muscle This “mechanism,” called the telomere (tee-lo-mere), is embedded in the core of every one of your cells, but “burns down” and gets shorter with age. And the shorter it gets, the weaker your cells become. Here’s the good news: Telomeres come equipped with an enzyme designed to rebuild it. This enzyme is usually “switched off,” but a series of discoveries has shown us how to switch it back on. In this special report, I’ll show you how to activate this enzyme and how you can easily revive your heart’s energy, vitality and pumping power. Just by doing this one thing, you can restore your heart to a level of power and performance you enjoyed when you were in your 30s and 40s. And you can keep this performance boost for life.

Reignite Your Heart’s Power with This Nobel Prize-Winning Technology Located in every chromosome, telomeres are the “time keepers” attached to every strand of your DNA. Each time your cells divide, your telomeres get shorter. When your telomeres run down, cell division stops and your life ends. By slowing down the loss of your telomeres, you not only extend your heart’s power, you stay younger longer. That’s what I do for my patients. And that’s what I’m going to show you today. As the telomere gets shorter, your body produces cells that are older, weaker and more decrepit. This speeding up of telomere loss actually causes your body to transcribe an older, more dysfunctional part of your genome. That means your body becomes weaker, more frail and open to all the pitfalls of aging. It’s “programmed old age” for your heart… complete with congestive heart failure, heart attack and

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hardening of the arteries. In fact, the shorter your telomeres, the “older” your heart is, regardless of your actual age. In this way, your telomeres “tell” or instruct your heart’s cells how to behave based on how old they are. This discovery was so groundbreaking, it won the Nobel Prize in Medicine in 2009. And there’s clear evidence that shorter telomeres weaken your heart and increase your risk of heart disease. Just have a look at these study results.

Short Telomeres Set You Up for Heart Attack, Heart Failure, Clogged Arteries and Early Death

The telomeres are the “protective tips” or “caps” at the ends of each strand of DNA. As a whole, your DNA contains the blueprint or program for EVERY cell in your body.

When researchers investigated the first long-term connection between telomeres and heart health over the span of two decades, the results were clear and conclusive.1

Published in the journal Arteriosclerosis, Thrombosis and Vascular Biology, the team of doctors at a research hospital in Denmark followed almost 20,000 people for 19 years. The people with short telomeres had a…

••50% increased risk of heart attack ••25% increased risk of early death Another study, published in the same journal, found an alarming increase in heart attack risk… this time, people with short telomeres had an increased risk between 280% and 320%! 2 These newly-reported results confirm what we now consider a FACT: Shorter telomeres make you a target for heart disease. Aside from heart attack, your risk of atherosclerosis or hardening of the arteries goes up to. In a study published in the prestigious journal Lancet, researchers found an association between short telomeres and atherosclerosis.3 The people with short telomeres had accelerated aging of their blood vessels and had a build up of plaque that correlated to someone 8.6 years older. This increased risk extends into the very fiber of your heart muscle. In a study published in the Journal of the American College of Cardiology, researchers discovered that people with heart failure had telomeres that were 40% shorter than normal. 4 Heart failure is now characterized by both telomere erosion and the death of cardiac “myocytes.” These are the muscle cells in your heart and are responsible for generating the electrical impulses that control your heart rate, among other things. But there is good news. At the beginning of this report, I mentioned the telomere comes equipped with an enzyme designed to

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rebuild it. That enzyme, called telomerase, can extend the length of your telomeres. And when you switch on telomerase and make telomeres longer, you regenerate your heart’s cells… regardless of how old you are.

The Newly-Discovered Power of the Famous “Red Wine” Nutrient By now I’m sure you’ve heard of resveratrol. Resveratrol is a nutrient found in red wine, and has been the focus of national media, being featured on 60 Minutes, Oprah and the Dr. Oz show. Known as a “longevity nutrient,” resveratrol has multiple heart benefits and is able to normalize your blood pressure and cholesterol levels. But recently, researchers discovered something new about resveratrol… it has the power to switch on the gene that produces telomerase, the enzyme that rebuilds your telomeres. Published in the English version of the Chinese Medical Journal, researchers found resveratrol, “significantly increased telomerase activity.” 5 And that’s great news… it means you have a simple and reliable way of rebuilding your telomeres and keeping your heart young and vital. And when we’re talking about telomerase, it’s important to remember that adding length to your telomeres means you can actually make your heart younger. That’s the key to understanding this newest breakthrough… You see, the length of your telomere dictates the kind of cell your body produces. Longer telomeres produce younger-acting cells. That’s what gives you the experience a full “restoration.” Your body is literally creating a younger, more powerful heart… even though you’re technically getting older with each passing day. We’ve known for years that resveratrol can “turn on” genes that promote health and longevity, and “turn off ” genes that cause cancer and heart disease. But this new study, throws the door wide open. For the first time, we have reliable evidence that a simple, easy-to-take nutrient can re-energize your tired heart. Let me show you how this genetic switch works…

Resveratrol Switches On Your “Anti-Aging Gene” Your body has a gene that can increase lifespan dramatically… one study saw an increase by as much as 100%.6 All living things carry it, including humans. Even more exciting is the discovery that natural substances found in certain foods have the power to activate this gene. We first discovered evidence of this “longevity gene” about twenty years ago. If you starve mice, giving them a nutritionally balanced diet with very few calories, their lifespan increases dramatically. Later studies revealed that this strange effect wasn’t limited to mice: calorie-restricted diets produced similar results in many life forms, from single celled organisms to plants and mammals.7 Very recently, we found the explanation for this mysterious phenomenon. They isolated a family of genes

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called sirtuins (“silent information regulator proteins”). Sirtuins kick in under conditions of severe stress, bringing about a miraculous transformation. They transmit signals to every cell in your body that literally cancel out the effects of aging. The processes that lead to cell death slow to a crawl, buying your body more time. The discovery of sirtuins pointed to another amazing fact. Most folks think of genetics as written in stone. You have the genes you inherited, and that’s it. What sirtuins show is that certain genes can be awakened and called upon to change your body in the course of a single lifetime.

When Resveratrol Rebuilds Your Telomeres Your Heart Springs Back to Life When resveratrol acts on your telomeres, two things happen: First, resveratrol protects your telomeres from becoming shorter. That immediately slows the aging of your heart. Second, resveratrol activates the telomerase enzyme, and gradually starts to rebuild your telomeres. That enables your heart to produce younger cells. And that produces some remarkable benefits: One way resveratrol protects your heart is by preventing blood clots, a major cause of heart attack, particularly in older folks. In one study, researchers gave healthy male subjects a blood-clotting factor along with high doses of resveratrol. They found that resveratrol prevented their blood platelets from sticking together.8 Not only does this help your heart, it also prevents strokes, another effect of clotting. Another way it powers your heart involves miraculous capability called “angiogenesis,” a fancy term for blood vessel growth. Resveratrol acts a bit like bypass surgery by creating new blood vessels to deliver more oxygen to your heart when it’s not getting enough. Resveratrol also acts as a potent antioxidant, binding with “free radicals,” the molecules that cause cell damage and lead to death over time. Oxidative stress is the cause of many diseases and aging itself. And many scientists report that resveratrol slows down the oxidation of dangerous low-density lipoprotein (LDL) and scavenges very harmful hydroxyl radicals. Resveratrol also helps to protect your levels of glutathione, which is your body’s “master antioxidant” and detoxifier. Finally trans-resveratrol drives down levels of bad fats called triglycerides. These are the fatty acids that clog your arteries. Scientists have been able to lower triglyceride levels as much as 15 percent in pre-menopausal women using concentrated grape powder.9 As powerful as resveratrol is, your telomeres are VERY sensitive to oxidative stress. And that’s why I recommend the most powerful antioxidants to my patients. If you were sitting in my consulting room, I’d tell you same thing. To maintain what I like to call your “hundred-year heart,” there are a few other nutrients you should consider.

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Is Your Heart “Starving” for these 4 Must-Have Nutrients? In medical school, physicians receive very little training in nutrition. Traditional medical education focuses on disease rather than health. As a result, most doctors remain woefully unable to advise you about nutrition and nutritional supplements to help you heal your heart and avoid cardiovascular disease. Yet good nutrition is essential for a healthy heart. Your heart never gets to rest. Until the moment of your death, your heart steadily and tirelessly keeps the rhythm of your life. Your heart can only perform this staggering feat if it has an adequate supply of nutrients. To keep your heart pumping strong, feed it the nutrients it needs. Research conducted at my Wellness Research Foundation along with the experience with thousands of patients shows that most heart disease sufferers are deficient in one or more of five key nutrients: CoQ10, L-carnitine, L-arginine, Vitamin E, and Vitamin C. We’ve talked about CoQ10, and why resveratrol is now an essential for heart health. Now let’s take a look at the four nutrients I consider the most overlooked.

Rejuvenate Your Heart with these 4 “Super-Nutrients” While a good multivitamin forms a foundation toward a well-nourished heart, you can further protect your heart with a few additional key nutrients: L-carnitine, L-arginine, tocopherols and tocotrienols (vitamin E), and antioxidant doses of vitamin C.

L-Carnitine: Your Fat-Burning Furnace L-carnitine plays an essential role in the healthy functioning of the body. Every form of life, from the simplest single-cell organism to the unfathomably complex human body, depends on carnitine for energy production within the cells. Carnitine shuttles fat (or long-chain fatty acids, to be more precise) into the energy centers or mitochondria of the cells, where the fat can be burned to produce energy. Without enough carnitine, the cell’s furnace cannot work at peak efficiency and its energy-production system slows down or stalls. When the body has sufficient carnitine reserves, the cells can burn more fat and generate more energy. In addition to generating energy, fat burning creates even more health benefits. For example, carnitineenhanced fat burning prevents the accumulation of excess fat in the heart, liver, and muscles. If allowed to build up, this fat contributes to a number of different health problems, such as heart disease, diabetes, and high triglyceride levels. Carnitine is present in greatest concentrations in the heart, brain, muscles, and testicles, all of which require lots of energy. Carnitine is often referred to as “the energy vitamin,” but it is not really a vitamin at all. A vitamin is a substance that cannot be produced by the body and must be obtained through food. Because the body can synthesize carnitine from the amino acids lysine and methionine, carnitine is not a true vitamin. Other people classify carnitine as an amino acid, but it isn’t a true amino acid, either. While carnitine has a chemical structure similar to many amino acids, technically it is a nitrogen-containing, short-chain carboxylic

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acid. In simple terms, carnitine is a water-soluble, vitamin-like compound similar to the B-complex groups of vitamins. More than 20 placebo-controlled studies support L-carnitine’s role in protecting your heart.10 Carnitine reduces arterial plaque, lowers LDL cholesterol, and increases HDL levels. These benefits appear in healthy subjects as well as in patients with heart disease. You obtain carnitine from red meat and dairy. In fact, when scientists first isolated it from the muscle tissue of several animals, they named it carnitine, using the Latin root carn, meaning flesh or meat. Unless you eat a diet high in red meat and dairy, it can be difficult to obtain optimal amounts of carnitine from dietary sources alone. Take 500 milligrams of L-carnitine as a supplement every day. It is important that you choose the naturally occurring L-carnitine and not the synthetic D, L-carnitine. The D-form interferes with the natural action of the L-carnitine.

Build a Better Heart with L-Arginine L-arginine, a naturally occurring amino acid, is the precursor to nitric oxide. L-arginine improves blood flow because in the bloodstream it breaks down into nitric oxide, which helps dilate the blood vessels in the lining of the heart. Without nitric oxide, your blood vessels narrow. Arterial plaque makes these vessels rigid and restricts blood flow. Recent studies show that arginine supplementation effectively increases the elasticity of blood vessels, providing a much safer alternative to prescription drugs.11 L-arginine also assists in muscle building, and remember, your heart is a muscle. One double-blind study measured the change in muscle strength and lean muscle mass in men taking L-arginine. Men in the study took either L-arginine or a placebo while participating in a strength-training program. Those taking the L-arginine showed a significantly greater increase in muscle strength and lean muscle mass after only five weeks.12 Supplements containing L-arginine have been used by athletes for more than 20 years but have become more popular in recent years. Why? Because of the popularity and expense of the prescription drug Viagra. Viagra, like, arginine improves blood flow by increasing nitric oxide. Good food sources of L-arginine include red meat, fish, chicken, beans, chocolate, raisins, nuts, sesame seeds, and sunflower seeds. You can also now find it in supplement form in most nutrition stores. Take 500 milligrams of L-arginine daily with food to support muscle growth and heart health. Like carnitine, buy only the L-form of this amino acid.

2 Forms of Vitamin E Lengthen Your Telomeres You may already know that vitamin E helps protect your heart. A number of studies show a link between vitamin E and lowered risk of heart disease. Two landmark studies in The England Journal of Medicine report heart protection from Vitamin E alone. One eight-year study tracked more than 87,000 registered female nurses.13

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A related study followed nearly 40,000 male health care workers.14 People who took daily vitamin E supplements (100 IU or more) for a minimum of two years had about a 40 percent (41 percent in women, 37 percent in men) lower risk of heart disease. They also had a 29 percent lower risk of stroke, and a 13 percent reduction in overall death rates. This conclusion continues to be supported by the bulk of the evidence but some studies find conflicting results because the supplemental form of vitamin E is a partial solution. New evidence shows that a more natural group of vitamin E-like compounds are more effective. In nature, vitamin E exists as a mixture of four types of tocopherols and four types of tocotrienols. So there are eight forms of Vitamin E in total. The vitamin E you find on the drug store shelves contains a single type of tocopherol known as alphatocopherol. Taking too much of one tocopherol can block the absorption of the other tocopherols. For this reason, take a blend of both tocopherols and tocotrienols, which is much closer to the way these nutrients exist in nature. Tocopherols and tocotrienols have many proven health benefits. Tocopherols and tocotrienols fight the free radicals in your body that cause diseases of inflammation (such as rheumatoid arthritis). They also lower your risk of heart disease by increasing your blood circulation. They also lower your risk of cancers of the prostate, colon, and breast. Many patients have been able to give up their blood-thinning drugs after they begin tocopherol supplementation. There is evidence that a daily supplement of mixed tocopherols increases the elasticity of the arteries.15 These nutrients also lower risk of heart disease by increasing blood circulation and decreasing the stickiness of platelets in your blood.16 Today, we know that two forms of vitamin E can activate telomerase and lengthen your telomeres. The most well-known form of vitamin E, alpha tocopherol protects against telomere shortening by activating and restoring telomerase.17 That may explain why vitamin E can help prevent heart disease… but there’s more: One of the four lesser-known forms of vitamin E, gamma tocotrienol can, “modulate the length of the telomere possibly via telomerase.” During one study, telomere lengths were 16% longer than controls when exposed to gamma tocotrienol.18 You find tocopherols and tocotrienols in “fatty foods,” including meat, fish, nuts, oils, dark-green leafy vegetables, seeds, and avocados. However, it is virtually impossible to consume enough of these nutrients in a typical diet. For example, you would have to eat two pounds of sunflower seeds every day to consume all of the tocopherols and tocotrienols you need. Take 400 IU of vitamin E (mixed tocopherols) with at least 5 mg (20mg is optimal) of mixed tocotrienols daily. Vitamin E and the other tocopherols are oil soluble. Like the old form of CoQ10, your body can only absorb these nutrients when you eat enough fat. Take them with a teaspoon of almond butter or other natural fat or oil like cod liver oil.

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Take Vitamin C for Longer Telomeres Vitamin C earned a reputation as a preventative for colds since its discovery more than 70 years ago. And vitamin C has a lot more to offer! It is essential for many of the body’s life-sustaining functions. For example, vitamin C:

••Fights free radicals. ••Helps form collagen and elastin, (supportive proteins in the tissues, especially your blood vessel walls).

••Sustains your immune system. ••Aids in the production of amino acids that regulate the nervous system. ••Helps break down histamines which are the inflammatory element of allergic reactions, among many additional functions.

The Noble Prize winning scientist Linus Pauling was the first to claim that vitamin C could extend your life. Dr. Pauling took between 12,000 and 18,000 mg of vitamin C every day for 40 years. Pauling’s theory was dismissed until the 1980’s when scientists discovered that antioxidants could protect cells from oxidative damage. The free radical theory of aging became popular. Vitamin C was found to be among the nutrients that protect cells from free radicals. But oxidative damage to cells can be repaired. It is the oxidative damage to telomeres that is not repaired. This results in further shortening of telomeres. This very specific effect of free radical damage helps drive the aging process. In 1998 a Japanese study tested vitamin C’s effect on telomeres. It was found that raising the level of vitamin C in the cells could slow down the loss of telomeres up to 62%.19 When it comes to cardiovascular disease, studies find a link between low levels of vitamin C and risk of stroke. A 10-year study of more than 2,400 middle-aged men established a relationship between vitamin C intake and reduced risk of stroke.20 Men with the lowest vitamin C levels had an increased risk of having a stroke 2.4 times greater than men who had higher vitamin C levels. The researchers found that taking vitamin C had more impact on the risk of stroke than being overweight or having high blood pressure. In addition, researchers at the University of California analyzed the vitamin C intakes and death rates of more than 11,000 men and women.21 The study showed a dramatic decline in death from heart disease among the men with the highest vitamin C intake, especially among those who took a vitamin C supplement. Merely obtaining the recommended daily allowance for vitamin C through food did not seem to offer any protection against heart disease. Keep in mind, the human body cannot synthesize or produce vitamin C. We can only get this nutrient from our diet -- or from supplements. Unfortunately, one-fourth of all Americans do not get even the minimum amount of vitamin C (60 milligrams) that cells need to perform basic biological functions. Foods like oranges, strawberries, broccoli, and bell peppers contain substantial amounts of vitamin C. But still, it is difficult to consume therapeutic amounts of

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vitamin C from diet alone. Some drugs, including aspirin, alcohol, analgesics, anti-depressants, anti-coagulants, oral contraceptives, and steroids, reduce the levels of vitamin C in the body. Diabetic and sulfa drugs may not be as effective when taken with large doses of vitamin C. Large doses of vitamin C may cause false negative readings when testing for blood in the stool. Take at least 500 milligrams of vitamin C twice a day with food. At higher doses for shorter periods, vitamin C provides some protection against viruses. If you have a viral illness (such as a cold), take 1,000 milligrams every couple of hours with a full glass of water. Reference: 1 Weischer M, et al. Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):82209. 2 Brouilette S, et al. White cell telomere length and risk of premature myocardial infarction. Aterioscler Thromb Vasc Biol. 2003 May 1;23(5):842-6. 3 Samani NJ, et al. Telomere shortening in atherosclerosis. Lancet. 2001 Aug 11;358(9280):472-3. 4 van der Harst P, et al. Telomere length of circulating leukocytes is decreased in patients with chronic heart failure. J Am Coll Cardiol. 2007 Apr 3; 49(13):1459-64. 5 Wang XB, et al. Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells. Chin Med J (Engl). 2011 Dec;124(24):4310-5. 6 Howitz et al, “Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan,” Nature, 2003, 425(6954):191-6. 7 Sinclair DA, Guarente L, “Unlocking the secrets of longevity genes,” Scientific American, 2006, 294(3): 48-57. 8 Wang et al, “Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro,” International Journal of Molecular Medicine, 2007 9(1):77-9. 9 Zern et al, “Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress,” The Journal of Nutrition, 2005, 135(8):1911-7. 10 Borum RP and Bennett SG. Carnitine as an essential nutrient. Journal of American College of Nutrition. 1986; 5(2):177-182. 11 Antioxidant-Amino Acid Mix Shields Blood Vessels, Reuters Health, 1/22/03. 12 Elam R, Hardin DH, Sutton RA, and Hagen L. Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males. Journal of Sports Medicine and Physical Fitness, 1989 Mar; 29(1):52-56. 13 Stampfer MJ, Hennekens CH, Manson JE, et al. Vitamin E consumption and the risk of coronary disease in women. New England Journal of Medicine. 1993 May 20; 328(20):1444-1449. 14 Rimm EB, Stampfer MJ, Ascherio A, et al. Vitamin E consumption and the risk of coronary heart disease in men. New England Journal of Medicine. 1993 May 20; 328(20):1450-1456. 15 Mottram P, Shige H, and Nestel P. Vitamin E improves arterial compliance in middle-aged men and women. Atherosclerosis. 1999 Aug; 145(2):399-404. 16 Mabile L, Bruckdorfer KR and Rice-Evans C. Moderate supplementation with natural alpha-tocopherol decreases platelet aggregation and low-density lipoprotein oxidation. Atherosclerosis. 1999 Nov 1; 147(1):177-185. 17 Makpol S, Zainuddin A, Rahim NA, Yusof YA, Ngah WZ. Alpha-tocopherol modulates hydrogen peroxide-induced DNA damage and telomere shortening of human skin fibroblasts derived from differently aged individuals. Planta Med. 2010 Jun;76(9):869-75. 18 Suzana Makpol, et al. Gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. Oxidative Medicine and Cellular Longevity. 3(1); Jan-Feb 2010. 19 Furumoto K. et al. “Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress.” Life Science 1998, vol. 63, no. 11 pp. 935-48. 20 Kurl S, Tuomainen TP, Laukkanen JA, et al. Plasma vitamin C modifies the association between hypertension and risk of stroke. Stroke. 2002 Jun; 33(6):1568-1573. 21 Enstrom JE, Kanim LE and Kleim MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992 May; 3(3):194-202.

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Dr. Sears’

Telomere

Secrets Volume 4: 1:

Extinguish Activate thethe FireEnzyme of Inflammation that Rebuilds Your Telomeres

© 2014 by Wellness Research & Consulting Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. Published by: Al Sears, MD 11905 Southern Blvd., Ste. 102 Royal Palm Beach, FL 33411 561-784-7852 www.AlSearsMD.com Dr. Al Sears wrote this report to provide information in regard to the subject matter covered. It is offered with the understanding that the publisher and the author are not liable for any misconception or misuse of the information provided. Every effort has been made to make this report as complete and accurate as possible. The purpose of this report is to educate. The author and the publisher shall have neither liability nor responsibility to any person or entity with respect to any loss, damage, or injury caused or alleged to be caused directly or indirectly by the information contained in this report. The information presented herein is in no way intended as a substitute for medical counseling or medical attention.

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Uniquely Qualified to Keep You Healthier For Life Al Sears, M.D. currently owns and operates a successful integrative medicine and anti-aging clinic in Royal Palm Beach, Florida, with over 25,000 patients. His cutting-edge therapies and reputation for solving some of the most difficult-to-diagnose cases attract patients from around the world. As a graduate of the University of South Florida College of Medicine, Dr. Sears scored in the 99th percentile on his MCAT and graduated with honors in Internal Medicine, Neurology, Psychiatry, and Physical Medicine. After entering private practice, Dr. Sears was one of the first to be board-certified in anti-aging medicine. As a pioneer in this new field of medicine, he is an avid researcher, published author, and enthusiastic lecturer. He is the first doctor licensed in the U.S. to administer TA-65, the most important breakthrough in anti-aging medicine today. Dr. Sears is board-certified as a clinical nutrition specialist and a member of the American College of Sports Medicine (ACSM), the American College for the Advancement in Medicine (ACAM), the American Medical Association (AMA), the Southern Medical Association (SMA), the American Academy of Anti-Aging Medicine (A4M), and the Herb Research Foundation, (HRF). Dr. Sears is also an ACE-certified fitness trainer. Dr. Sears currently writes and publishes the daily email broadcast, Doctor’s House Call, and contributes to a host of other publications in the field. He has appeared on over 50 national radio programs, ABC News, CNN, and ESPN. Since 1999, Dr. Sears has published 14 books and over 100 reports on health and wellness with a readership of millions spread over 163 countries. In his first book, The T-Factor, King of Hormones, Dr. Sears perfected the use of natural and bio-identical testosterone boosters to help men restore the drive, ambition, muscle strength, vitality and sexual performance of their youth. Dr. Sears followed up with 12 Secrets to Virility, a full-blown strategy for male performance that includes his own patient-tested protocols for successfully dealing with men’s health concerns like fighting excess estrogen, protecting the prostate, eliminating fat gain and keeping a sharp mind and memory. In 2004, Dr. Sears was one of the first to fight against the conventional belief that cholesterol causes heart disease, proving that cholesterol is not the cause, but the part of the body that heart disease acts upon. In The Doctor’s Heart Cure, Dr. Sears offers an easy-to-follow solution that effectively eliminates your risk of heart disease, high blood pressure and stroke. In 2009, Dr. Sears shocked the fitness world by revealing the dangers of aerobics, “cardio” and long-distance running in his book, PACE: The 12-Minute Fitness Revolution. Expanding on the fitness principles in The Doctor’s Heart Cure, he developed a fast, simple solution to restore muscle strength, guard against heart attack and burn excess fat. Today, PACE is practiced by thousands of people worldwide. In 2010, Dr. Sears made history by bringing telomere biology to the general public. As the first U.S. doctor

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licensed to administer a groundbreaking DNA therapy that activates the gene that regulates telomerase, his breakthrough book Reset Your Biological Clock shows how anyone can preserve the energy of youth by controlling the length of your telomere, the true marker of aging. An avid lecturer, Dr. Sears regularly speaks at conferences sponsored by the American Academy of AntiAging Medicine (A4M), the American College for the Advancement of Medicine (ACAM), the Age Management Medicine Group (AMMG), and the Society for Anti-Aging, Aesthetic and Regenerative Medicine Malaysia (SAAARMM). As the founder and director of Wellness Research Foundation, a non-profit research organization, Dr. Sears has made it his life’s work to bring his patients the latest breakthroughs in natural therapies. As part of his ongoing research, Dr. Sears travels the world in search of herbs, novel cures and traditional remedies. Meeting with doctors and healers, Dr. Sears has brought back and revitalized much of the traditional knowledge considered endangered in today’s modern world.

••During an expedition to the Peruvian Andes, Dr. Sears brought back a nutrient-dense oil made from the Sacha Inchi nut, containing the highest plant source of heart and brain boosting omega-3 fatty acids.

••In India, Dr. Sears studied at the oldest existing school of Ayurvedic medicine, the ancient

Indian healing tradition, and was tutored by Ayurvedic doctors on the use of potent Indian herbs used to treat heart disease, cancer and Alzheimer’s disease.

••While trekking through the Amazon rainforest in Brazil, Dr. Sears lived among the native Ashaninka Indians, incorporating their ancient knowledge of healing herbs into his own nutritional supplement formulas.

••In Jamaica, Dr. Sears met with the last living healer from the ancient and forgotten lineage

known as the Maroons. Coming from West Africa 500 years ago, their knowledge was on the brink of extinction until Dr. Sears published a book showcasing their unique herbs and healing formulas.

••On the island of Bali, Dr. Sears had a meeting with the most famous of the ancient healers

known as “Balians,” – Ketut Leyir – and also met two of the country’s foremost herbalists. Dr. Sears is publishing a book showing how to use Balinese herbs and make unique healing mixtures for the skin and body.

With a life-long interest in botany, herbology, physiology and anthropology, Dr. Sears has a unique capacity to investigate the evidence behind the stories and claims of traditional medicine from native cultures around the world. By exposing the flaws of mainstream medicine and pioneering new solutions through innovative approaches to exercise, nutrition and aging, Dr. Sears continues to empower the lives of his patients and readers through his books, newsletters and regular media appearances.

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Dr. Sears’ Telomere Secrets: Volume 4: Extinguish the Fire of Inflammation It’s the longest organ you’ve never heard of… Running over 93,000 miles long, this thin barrier is so important that in one way or another, it can be linked to most heart-related diseases like high blood pressure and heart disease. It’s a living, intelligent and reactive system. It protects the vessels of every other organ system, even your eyes and your lymph nodes. Your blood brain barrier is part of it, too. This organ is called the endothelial cell barrier, or ECB for short. It’s a dynamic system that also regulates the flow of almost every biologically active molecule in your body. You could think of it as a relative of the largest organ in your body, your skin. It shields you from attacks on the outside, and your ECB does a similar job on the inside. But there’s a problem.

This Forgotten Organ is Under Attack… And On Fire Ignited by toxins, pollutants, and the rise of vegetable oils and unnatural fats, this “fire of inflammation” scorches and consumes the inner lining of your blood vessels, and is the primary cause of heart attack, stroke and a host of chronic diseases. But new studies suggest inflammation has a deeper, little-known cause… a “cellular trigger” hiding deep within your DNA. This genetic material also provides an unlikely solution. In this special report, I’ll show you how these secret triggers — hiding deep within your cells — are the true culprit behind the modern epidemic of inflammation and the diseases that come with it. You’ll also find out how this same breakthrough gives you new options for healing and repairing your blood vessels… even if you’ve already suffered a heart attack. PLUS you’ll discover the “super nutrient” that mobilizes your body’s secret store of “protector cells” that not only extinguish the fire but make repairs to damaged blood vessels. First, let me show you what this “cellular trigger” really is.

The Discovery of Our Time Unveils the True Mechanism Behind Inflammation Deep within your DNA, located in the nucleus of each cell, are the building blocks or “blueprint” of every cell in your body. At the end of each strand of DNA is a little bit of genetic material called the telomere (tee-lo-mere). The telomere is the part of your chromosome that controls aging. And every time your cells divide, your telomeres get shorter. And when your telomeres finally run out, cell division stops and life comes to an end.

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But there’s more to it than that. As you age and your telomeres get shorter, your body produces cells that are older, weaker, and more decrepit. In fact, the shorter your telomeres, the “older” your body is, regardless of your actual age. In this way, your telomeres “tell” or instruct your cells how to behave based on how old they are. And for your endothelial cell barrier, or ECB, short telomeres light the match that ignites inflammation. But when you slow the loss of your telomeres, you can extend the youthful quality of your blood vessels and avoid disease altogether. And that’s the key.

Telomeres are the caps at the end of each chromosome.

Today, I’ll show you HOW to influence your telomeres so you can reverse the damage to your ECB. And that includes getting rid of plaque buildup in your arteries. Here’s what we know.

The Length of Your Telomeres Determines Your Risk for Chronic Inflammation At it’s most basic level, inflammation is a natural defense mechanism our bodies use to protect us. Like when you cut your finger, the area around the cut becomes swollen or inflamed as a way to isolate the injury and trigger the release of white blood cells and other factors that promote a healing response. And that’s a good thing. A healthy inflammation response is essential for life. Chronic inflammation, on the other hand, is a condition where a particular area is ALWAYS irritated, swollen and inflamed. And it’s chronic inflammation that destroys the ECB. Your ECB can be as thin as a single layer of cells that wrap the inner lining of your blood vessels… and it’s no wonder that chronic, round-the-clock inflammation can weaken and eventually destroy this vital, protective covering. For years, doctors in the know have warned their patients about the causes of chronic inflammation like smoking, environmental toxins, and processed foods, like the vegetable oils in so many of our foods. But new studies suggest the telomere is the controlling element, and ultimate trigger for the kind of chronic inflammation that leads to heart attack, stroke, heart disease and mental decline. That is a true breakthrough, because it means you have a lot more control over your health and your future than you may have thought. As you’ll see, when you CONTROL the length of the telomere, you can stop and reverse the damage caused by chronic inflammation.

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Cells with Short Telomeres Produce the Factors that Cause Inflammation A new, compelling study from the University of California at San Francisco gives us clear evidence that telomere length determines your risk and severity of inflammation. After acknowledging that, “cells with critically short telomeres produce pro-inflammatory factors,” researchers studied 1,962 healthy men and women between the ages of 70 and 79. And their findings confirmed previous research: People with short telomeres had high levels of two proinflammatory factors interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-a).1 Both IL-6 and TNF-a are known as cytokines, a group inflammatory compounds that cause chronic inflammation… and lead to disease. We also know from two separate studies, one published in the journal Oncogene, and the other published in the journal Blood, that TNF-a blocks telomerase, the enzyme that rebuilds your telomeres.2 3 From these studies, we learn that:

••Not only do short telomeres create a breeding ground for inflammatory compounds… ••But that once inflammation occurs, cytokines like TNF-a shut down telomerase. These results show how short telomeres threaten your endothelial cell barrier, or ECB in general. But from other studies we can see how short telomeres cause inflammation to specific organs and tissues. Published in the journal American Journal of Respiratory and Critical Medicine, the study’s title tells the whole story: “Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease…” In simplified terms, short telomeres drive and maintain the inflammation associated with the lung disease COPD.4 Part of the danger of inflammation, especially when it threatens the ECB, is that there’s nowhere to hide. Your ECB covers every inch of your body from head to toe. It’s not surprising then, to find that short telomeres trigger all the familiar forms of heart disease, including atherosclerosis or hardening of the arteries… which, as you know, can clog any stretch of your vasculature, anywhere in your body. A collection of studies confirm this, showing us that short telomeres are associated with atherosclerosis, heart attack and high blood pressure.5 6 7 But here’s the good news. You can ease inflammation and support your telomeres with a few high-powered nutrients.

This “Super Nutrient” Mobilizes a Secret Army of Blood Vessel Builders Here’s great news for your ECB: Researchers uncovered “hidden” benefits from the popular heart and longevity nutrient resveratrol. Turns out resveratrol stimulates the production of adult stem cells called endothelial progenitor cells.

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These stem cells are so powerful, they have the ability to seek out, repair and heal the trouble areas in your ECB. Since the release of a landmark study published in the New England Journal of Medicine in 2003, scientists and researchers have focused more and more on the power of these endothelial progenitor cells. And for good reason. The study from the New England Journal of Medicine showed a “strong correlation” between the number of progenitor cells circulating in the blood and a person’s overall risk of heart disease.8 The connection is so strong, many believe the number of progenitor cells will become the new “marker” of cardiovascular health, even replacing the two major forms of cholesterol, HDL and LDL. Simply stated, the more of these progenitor cells you have, the more likely you are to avoid disease. This view is supported by the fact that patients with diabetes, high blood pressure and/or cardiovascular disease have low levels of progenitor cells. Studies showed, “the number of endothelial progenitor cells was significantly reduced in patients with hypercholesteroemia (extremely high cholesterol levels) compared with that in control subjects.” 9 In these patients with very high cholesterol, they found the ability of endothelial progenitor cells to proliferate, migrate, adhere to vessel walls and induce the regeneration of blood vessels was weakened. Resveratrol had the opposite effect. In numerous recent studies, resveratrol has been shown to increase the number of these endothelial progenitor cells.10 11 12 13 Resveratrol also has the distinction of activating telomerase, the enzyme that rebuilds your telomere. These two critical functions are enabled by resveratrol’s ability to “turn on” genes that promote longevity, and “turn off ” genes that promote disease.14 By influencing the way genes are expressed, resveratrol has the ability to activate anti-aging genes called sirtuins. Sirtuins transmit signals to every cell in your body that literally cancel out the effects of aging. They bring the processes that lead cell death to a crawl, buying your body more time to repair the DNA damage that brings life to an end. Resveratrol is in the skin of grapes. It protects the grape from threats such as cold weather, UV radiation and microbes. The amount of resveratrol in wine differs. White wine is not made with the skins like red is – so white wine has little resveratrol. Red wines from colder regions have the most resveratrol. Drinking one or two glasses of red wine is one way to benefit from resveratrol. To get the maximum amount choose wines from Burgundy and Argentina’s Cafayate Valley. Most red wines from California and Australia will have lower amounts. If you’re not a fan of red wine, resveratrol is also in:

••Raisins ••Purple Grape Juice ••Peanuts

••Mulberries ••Eucalyptus Trees ••Japanese knot wood

The problem lies in getting sufficient amounts of resveratrol. You’d need to drink 1,000 to 3,000 glasses of wine to experience the life extending benefits of resveratrol.

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Resveratrol supplements are a better option. They’re inexpensive and completely safe. You can take it any time of day, with or without food.You can find them in health food stores or on line. I recommend taking around 10 mg to 20 mg per day for telomerase activation and the stimulation of endothelial progenitor cells.

Resveratrol’s Little-Known “Cousin” Helps Reduce Inflammation Resveratrol has made a lot of headlines for everything it can do for your body. And as you just discovered, it helps activate telomerase and mobilizes stem cells that repair and maintain healthy arteries. Resveratrol used to be the only nutrient we knew of that could do this… until now. Resveratrol has a cousin that may be even more effective. It’s called pterostilbene (tero-STILL-bean). It can give you many of the same benefits, and when you look at the preliminary research, perhaps even a few more that resveratrol doesn’t give you. For example, studies have shown pterostilbene works harder to support the colon, brain, and cardiovascular system.15 16 In one study, researchers found that pterostilbene lowered cellular stress and improved cognition in animals. Both resveratrol and pterostilbene have remarkable effects on learning and memory. Pterostilbene was the most effective resveratrol-like compound at preventing loss of the neurotransmitter dopamine from memory centers in aging animals.17 Supplementation with pterostilbene reversed cognitive behavioral deficits. This study showed working memory function was correlated with levels of pterostilbene in the hippocampus, a key brain location where memory is processed. More to the point, pterostilbene may also be better than resveratrol at promoting a healthy, normal inflammatory response.18 But there are a few other differences. For starters, pterostilbene is more bioavailable.19 That means it gets absorbed into tissues more easily, so it can have its most beneficial effect. And while resveratrol fights free radicals in your bloodstream, pterostilbene targets these inflammatory molecules in a different way. In clinical studies, pterostilbene seems to block an enzyme that ordinarily would make some free radicals stronger.20 You can get pterostilbene from some of the same sources as resveratrol. Red-skinned grapes have some, as do vaccinium berries like blueberries, cranberries, lingonberries, bilberries, and the sparkleberry. Pterostilbene and resveratrol are found together in nature, and also work together in your body. When you combine them, the results are even better than using one without the other.21 The problem is, it’s very difficult to get an effective amount of both from drinking red wine or eating red grapes or bilberries. In cases like this, I recommend you take a supplement. Make sure you get a supplement that has both resveratrol and pterostilbene listed on the label. I recommend at least 50mg of pterostilbene taken with resveratrol daily.

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The Best Inflammation Fighter You’ve Never Heard Of… One of the ways I measure inflammation in my patients is a protein your liver makes in response to the presence of inflammation. It’s called C-reactive protein (CRP) and can be detected with a simple blood test. C-reactive protein is recognized as an excellent predictor of heart disease. When part of your body is injured, it sends out signals asking for help. The immune system responds by sending white blood cells and inflammatory molecules (including CRP) to the injured area. These defense cells try to fix the injured areas and fight off any intruders, but this defensive response causes inflammation. The inflammatory response requires energy in the form of oxidative “fire” that can damage surrounding tissues. Elevated CRP levels indicate that there is inflammation in the body. Using this measure, we can detect hidden heart disease using CRP better than with cholesterol levels. The New England Journal of Medicine published a study on CRP that involved nearly 28,000 participants. Researchers tried to predict cardiac events (heart attack and stroke) using LDL cholesterol and CRP levels in the blood. They found that CRP predicted cardiac events better than LDL cholesterol.22 What can you do to keep your levels of CRP low? One of the best ways is exercise. We discovered that even moderate physical activity can lower CRP levels. People who went from not exercising at all to exercising a small amount five times a week cut their CRP levels by as much as 30%.23 And there’s compelling evidence that a carotenoid called astaxanthin can lower inflammation and thereby lower your levels of CRP. Astaxanthin is the pigment that gives salmon its pink color and acts as a powerful antioxidant. In one study, volunteers took 4 mg of astaxanthin three times a day. Their CRP dropped almost 21% while the control group’s level continued to creep up.24 Astaxanthin also protects your DNA, your “cellular blueprint” that determines whether you stay healthy or get sick. In this new study, volunteers took either a placebo or 2 mg or 8 mg of astaxanthin. After 8 weeks, the marker that determines DNA damage dropped by a third in the 2 mg group. In the 8 mg group, it dropped by 43%.25 Like your ECB, your DNA is damaged by free radical molecules. These form when you’re exposed to things like pollution, smoke, radiation and processed food. Astaxanthin may just be the best antioxidant for DNA protection. It’s 6,000 times more effective than vitamin C, 800 times more than CoQ10 and 550 times more than vitamin E or green tea.26 27 Salmon is a great source. But buy wild salmon. It contains far more astaxanthin. Four ounces of farm raised Atlantic salmon contains about 0.5 to 1.1 mg of astaxanthin. But wild-caught sockeye salmon contains a whopping 4.5 mg.28 You can also find astaxanthin in pink-colored seafood like lobster, crab and shrimp. Or you can pick up a supplement at your favorite vitamin store. I suggest you take 4 to 8 mg a day.

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References: 1 Aoife O’Donovan, et al. Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study. PLoS One. 2011; 6(5): e19687. 2 Beyne-Rauzy O, Recher C, Dastugue N, Demur C, Pottier G, et al. Tumor necrosis factor alpha induces senescence and chromosomal instability in human leukemic cells. Oncogene 23: 7507-7516, 2004. 3 Beyne-Rauzy O, Prade-Houdellier N, Demur C, Recher C, Ayel J, Laurent G, Mansat-De Mas V. Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells. Blood 106: 3200-3205, 2005. 4 Amsellem V, et al. Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 Dec 15;184(12):1358-66. 5 Edo MD, Adres V. Aging, telomeres, and atherosclerosis. Review. Cardiovasc Res 66: 213- 221, 2005. 6 Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, et al. Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 37: 381-385, 2001. 7 Benetos A, Gardner JP, Zureik M, Labat C, Xiaobin L, et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension 37: 381-385, 2001. 8 Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003 Feb 13;348(7):593-600. 9 Chen JZ, Zhang FR, Tao QM, Wang XX, Zhu JH, Zhu JH. Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia. Clin Sci (Lond). 2004 Sep;107(3):273-80. 10 Balestrieri ML, Schiano C, Felice F, et al. Effect of low doses of red wine and pure resveratrol on circulating endothelial progenitor cells. J Biochem (Tokyo). 2007 Nov 4. 11 Wang XB, Huang J, Zou JG, et al. Effects of resveratrol on number and activity of endothelial progenitor cells from human peripheral blood. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1109-15. 12 Lefèvre J, Michaud SE, Haddad P, et al. Moderate consumption of red wine (cabernet sauvignon) improves ischemia-induced neovascularization in ApoE-deficient mice: Effect on endothelial progenitor cells and nitric oxide. FASEB J. 2007 Jul 19. 13 J G, Cq W, Hh F, et al. Effects of resveratrol on endothelial progenitor cells and their contributions to reendothelialization in intimainjured rats. J Cardiovasc Pharmacol. 2006 May;47(5):711-21. 14 Wang XB, Zhu L, Huang J, Yin YG, Kong XQ, Rong QF, Shi AW, Cao KJ. Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells. Chin Med J (Engl). 2011 Dec;124(24):4310-5. 15 Nutakul W, et al, “Inhibitory effects of resveratrol and pterostilbene on human colon cancer cells: a side-by-side comparison,” J Agric Food Chem. 2011;59(20):10964-70. 16 Mikstacka R, et al, “Antioxidant effect of trans-resveratrol, pterostilbene, quercetin and their combinations in human erythrocytes in vitro,” Plant Foods Hum Nutr. 2010;65:57-63. 17 Joseph JA, Fisher DR, Cheng V, Rimando AM, Shukitt-Hale B. “Cellular and behavioral effects of stilbene resveratrol analogues…” J Agric Food Chem. 2008 Nov 26;56(22):10544-51. 18 Chang J, et al, “Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer’s disease,” Neurobiol Aging. 2011 Oct 7. [Epub ahead of print] 19 Kapetanovic IM, et al, “Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats,” Cancer Chemother Pharmacol. 2011;68(3):593-601. 20 Mikstacka R, et al, “Inhibition of human recombinant cytochromes P450 CYP1A1 and CYP1B1 by trans-resveratrol methyl ethers,” Mol Nutr Food Res. 2007;51(5):517-24. 21 Mikstacka R, et al, “Antioxidant effect of trans-resveratrol, pterostilbene, quercetin and their combinations in human erythrocytes in vitro,” Plant Foods Hum Nutr. 2010;65:57-63. 22 Ridker P, Rifai N, Rose L, et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the predication of first cardiovascular events. New England Journal of Medicine. 2002 Nov 14; 347(20):1557-1565. 23 Church T, Barlow CE, Earnest CP, et al. Association between cardiorespiratory fitness and C-reactive protein in men. Arteriosclerosis and Thrombosis: Journal of Vascular Biology. 2002 Nov 1; 22(11):1869-1879. 24 Spiller, G., Dewell, A., et al. “Effect of daily use natural astaxanthin on C-reactive protein.” Health Research & Studies Center, Los Altos, CA January 31, 2006. 25 Park JS, Chyun JH, Kim YK, Line LL, Chew BP. “Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans.” Nutrition & Metabolism 2010, 7:18, 5 March 2010. 26 Bagchi , D. “Oxygen free radical scavenging abilities of vitamin C, E, β-carotene, pycnogenol, grape seed extract and astaxanthin in vitro” Pharmacy Sciences Creighton University School of Health Sciences. 2001, June. 27 Pandey, S., Devmurari, V., Goyani, M., Bhavika, R.,“Anti aging therapy: Various alignments to control premature aging.” International Journal of Pharma and Bio Sciences 2010;V1(2). 28 Turujman, S. A., Wamer, W. G., Wei, R. R., and Albert, R. H. (1997) Rapid liquid chromatographic method to distinguish wild salmon from aquacultured salmon fed synthetic astaxanthin. J. AOAC Int., 80(3):622-632.

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Dr. Sears’

Telomere

Secrets Volume 5: 1:

Activate Erase Wrinkles the Enzyme and Turn that GrayingRebuilds Hair Back to Telomeres its Original Color Your

© 2013 by Wellness Research & Consulting Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the publisher. Published by: Al Sears, MD 11903 Southern Blvd., Ste. 208 Royal Palm Beach, FL 33411 561-784-7852 www.AlSearsMD.com Dr. Al Sears wrote this report to provide information in regard to the subject matter covered. It is offered with the understanding that the publisher and the author are not liable for any misconception or misuse of the information provided. Every effort has been made to make this report as complete and accurate as possible. The purpose of this report is to educate. The author and the publisher shall have neither liability nor responsibility to any person or entity with respect to any loss, damage, or injury caused or alleged to be caused directly or indirectly by the information contained in this report. The information presented herein is in no way intended as a substitute for medical counseling or medical attention.

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Uniquely Qualified to Keep You Healthier For Life Dr. Al Sears, M.D. currently owns and operates a successful integrative medicine and anti-aging clinic in Royal Palm Beach, Florida, with over 25,000 patients. His cutting-edge therapies and reputation for solving some of the most difficult-to-diagnose cases attract patients from around the world. As a graduate of the University of South Florida College of Medicine, Dr. Sears scored in the 99th percentile on his MCAT and graduated with honors in Internal Medicine, Neurology, Psychiatry, and Physical Medicine. After entering private practice, Dr. Sears was one of the first to be board-certified in anti-aging medicine. As a pioneer in this new field of medicine, he is an avid researcher, published author, and enthusiastic lecturer. He is the first doctor licensed in the U.S. to administer TA-65, the most important breakthrough in anti-aging medicine today. Dr. Sears is board-certified as a clinical nutrition specialist and a member of the American College of Sports Medicine (ACSM), the American College for the Advancement in Medicine (ACAM), the American Medical Association (AMA), the Southern Medical Association (SMA), the American Academy of Anti-Aging Medicine (A4M), and the Herb Research Foundation, (HRF). Dr. Sears is also an ACE-certified fitness trainer. Dr. Sears currently writes and publishes the monthly e-Newsletter, Health Confidential, and daily email broadcast, Doctor’s House Call, and contributes to a host of other publications in the field. He has appeared on over 50 national radio programs, ABC News, CNN, and ESPN. Since 1999, Dr. Sears has published 14 books and over 100 reports on health and wellness with a readership of millions spread over 163 countries. In his first book, The T-Factor, King of Hormones, Dr. Sears perfected the use of natural and bio-identical testosterone boosters to help men restore the drive, ambition, muscle strength, vitality and sexual performance of their youth. Dr. Sears followed up with 12 Secrets to Virility, a full-blown strategy for male performance that includes his own patient-tested protocols for successfully dealing with men’s health concerns like fighting excess estrogen, protecting the prostate, eliminating fat gain and keeping a sharp mind and memory. In 2004, Dr. Sears was one of the first to fight against the conventional belief that cholesterol causes heart disease, proving that cholesterol is not the cause, but the part of the body that heart disease acts upon. In The Doctor’s Heart Cure, Dr. Sears offers an easy-to-follow solution that effectively eliminates your risk of heart disease, high blood pressure and stroke. In 2006, Dr. Sears shocked the fitness world by revealing the dangers of aerobics, “cardio” and long-distance running in his book, PACE: The 12-Minute Revolution. Expanding on the fitness principles in The Doctor’s Heart Cure, he developed a fast, simple solution to restore muscle strength, guard against heart attack and burn excess fat. Today, PACE is practiced by thousands of people worldwide. In 2010, Dr. Sears made history by bringing telomere biology to the general public. As the first U.S. doctor

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licensed to administer a groundbreaking DNA therapy that activates the gene that regulates telomerase, his breakthrough book Reset Your Biological Clock shows how anyone can preserve the energy of youth by controlling the length of your telomere, the true marker of aging. An avid lecturer, Dr. Sears regularly speaks at conferences sponsored by the American Academy of AntiAging Medicine (A4M), the American College for the Advancement of Medicine (ACAM), the Age Management Medicine Group (AMMG), and the Society for Anti-Aging, Aesthetic and Regenerative Medicine Malaysia (SAAARMM). As the founder and director of Wellness Research Foundation, a non-profit research organization, Dr. Sears has made it his life’s work to bring his patients the latest breakthroughs in natural therapies. As part of his ongoing research, Dr. Sears travels the world in search of herbs, novel cures and traditional remedies. Meeting with doctors and healers, Dr. Sears has brought back and revitalized much of the traditional knowledge considered endangered in today’s modern world.

••During an expedition to the Peruvian Andes, Dr. Sears brought back a nutrient-dense oil made from the Sacha Inchi nut, containing the highest plant source of heart and brain boosting omega-3 fatty acids.

••In India, Dr. Sears studied at the oldest existing school of Ayurvedic medicine, the ancient

Indian healing tradition, and was tutored by Ayurvedic doctors on the use of potent Indian herbs used to treat heart disease, cancer and Alzheimer’s disease.

••While trekking through the Amazon rainforest in Brazil, Dr. Sears lived among the native Ashaninka Indians, incorporating their ancient knowledge of healing herbs into his own nutritional supplement formulas.

••In Jamaica, Dr. Sears met with the last living healer from the ancient and forgotten lineage

known as the Maroons. Coming from West Africa 500 years ago, their knowledge was on the brink of extinction until Dr. Sears published a book showcasing their unique herbs and healing formulas.

••On the island of Bali, Dr. Sears had a meeting with the most famous of the ancient healers

known as “Balians,” – Ketut Leyir – and also met two of the country’s foremost herbalists. Dr. Sears is publishing a book showing how to use Balinese herbs and make unique healing mixtures for the skin and body.

With a life-long interest in botany, herbology, physiology and anthropology, Dr. Sears has a unique capacity to investigate the evidence behind the stories and claims of traditional medicine from native cultures around the world. By exposing the flaws of mainstream medicine and pioneering new solutions through innovative approaches to exercise, nutrition and aging, Dr. Sears continues to empower the lives of his patients and readers through his books, newsletters and regular media appearances.

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Dr. Sears’ Telomere Secrets: Volume 5: Erase Wrinkles and Turn Graying Hair Back to its Original Color You are genetically programmed to wilt like a flower. That’s the reality. Every time your cells divide, your body sends a new command that causes your skin to become progressively dryer, droopier and full of new lines and wrinkles. Same with your hair and nails. They are programmed to lose their shine and luster. Over time, your hair thins and turns gray while your nails become brittle and cracked. It seems like an “act of fate,” but your body is simply following a script. Like actors reciting lines, your cells have no choice but to lose their power and good looks as they age. That’s the only storyline they know. But new discoveries show you can CHANGE the story… and CHANGE the script. By “writing” a new program, you can tell the cells in your skin, hair and nails to stop older and more decrepit. So instead of getting lines on your forehead and bags under your eyes, you can keep and maintain a fresh, radiant look as you age. You can even make repairs to your skin, which can make you look years younger. And in some cases, you can even “go back in time” and revive the genetic coding you had when you were in your twenties. In this special report, you’ll discover the NEW research behind the telomere and how it controls the way you look… from your hair, skin and nails, down to the way you appear older and less attractive as you age. You’ll find out how this breakthrough technology can increase skin tone and firmness, restore natural skin moisture, reduce the appearance of fine lines, wrinkles, age spots and large pores… and even turn your greying hair back to its original color. You’ll also find new ways of “reprogramming” your genetic code so you can keep that younger-looking version of yourself to star in your own life drama for years to come.

Your Cells Hold the Secret of Life-Long Sex Appeal Telomeres are the “time keepers” attached to every strand of your DNA. Each time your cells divide, your telomeres get shorter. When your telomeres run down, cell division stops and your life ends. By slowing down the loss of your telomeres, you not only extend your lifespan, you stay younger longer. That’s what I do for my patients. And it’s important you know how this works.

Telomeres are the caps at the end of each chromosome.

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As the telomere gets shorter, your body produces cells that are older, weaker and more decrepit. This speeding up of telomere loss actually causes your body to transcribe an older, more dysfunctional part of your genome. That means your body becomes weaker, more frail and open to all the pitfalls of aging. That includes your appearance, too… your skin, face and hair are EXTREMELY sensitive to telomere loss. One study found that people who look younger than their actual ages live longer than those who look older. In a long-term study involving 913 pairs of twins, Danish researchers discovered that the twins who looked younger than their true age had better health and longer survival rates than their older-looking siblings. And the larger the difference in perceived age, the more likely it was that the older-looking twin died first. And the reason for this difference? The people who looked younger had longer telomeres. Longer telomeres not only help you look better, but it increases your chances of living longer… and decreases your risk of chronic disease. But that’s not all.

These two women are twins, yet the twin on the left was perceived to be 64-years old, while the twin on the right was perceived to be 74-years old.

The twins with longer telomeres also had:

••Stronger Grip Strength: Measuring the strength of your grip correlates to overall muscle power and ability to perform daily activities.

••Greater Physical Function: As measured by an 11-point strength scale, like walking up two flights of stairs.

••Better Cognitive Ability: Compared to the twins with shorter telomeres, the twins with longer telomeres had better memories with faster recall.

••Longer Life Spans: The twins with longer telomeres lived longer than and had better survival

rates than their twins with shorter telomeres. They were also less likely to suffer from chronic diseases, like cancer, obesity and heart disease.

The message here is clear. When you preserve telomere length, you preserve life and youth. It means we now understand the very mechanism by which you age. And we’ve found a simple system that helps you preserve your telomeres and extend your lifespan. And when you preserve your telomeres, you LOOK younger and more attractive. Studies suggest that too much sun and UV exposure has a dramatic and debilitating effect on your telomeres. And these shrinking telomeres are the primary cause of “photo aging,” the damage caused by the sun’s rays. But when you PROTECT your telomeres from sun damage and REPAIR your DNA, you can reverse some of

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the damage and maintain younger-looking skin and hair. Let me explain.

Shrinking Telomeres Cause Your Skin to Get Old Before Its Time Dermatologists along with the cosmetic industry spend millions of dollars a year trying to convince you the sun is somehow “bad” for you. Their answer, of course, is to slather on layer after layer of sunscreens and tanning lotions. As you’ll discover later in this report, many of these products contain toxins that cause cancer and block your body’s ability to create vitamin D. But the sun is not your real enemy. Moderate sun exposure is essential for healthy skin and hair. The real problem is what overexposure does to the telomeres in your skin cells. A study published in the journal Micron found telomere shortening was the real culprit behind skin aging… and overexposure to the sun accelerated telomere shortening.1 By measuring telomere loss and sun exposure, researchers were able to show how telomere loss is the mechanism that creates the thick, coarse skin that comes from too much direct sun exposure. Dermatologists call this “photo aging.” In the study, researchers from the Department of Dermatology at the Boston University School of Medicine concluded that UV rays damage telomeres in two ways: 1) By creating proteins that directly damage the cells’ DNA where telomeres are located, and 2) by generating free radicals that attack and further degrade telomere length. To compare telomere length and the quality of skin, the team looked at the skin of a 91-year-old woman. Have a look at the pictures to the right. In photo A, you can see the effect of photo aging. The skin is darker, drier, heavier and marked by blemishes and age spots. And most notably, the photo-aged skin has shorter telomeres. Compare that to the woman’s “chronologically aged” skin in photo B. Without sun exposure, her skin remained softer, with more moisture and fewer lines, wrinkles and age spots. Why? Because the skin cells not exposed to the sun have

Telomere loss caused by photo aging created the thick, dry skin along with blemishes and age spots (photo A). The woman’s skin NOT exposed to the sun had longer telomeres and remained softer with fewer blemishes and wrinkles (photo B).

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longer telomeres. For the first time, we have conclusive evidence that telomere length is the true measure of how your skin ages. And it’s not hard to understand why. Your skin cells are the fastest-dividing cells in the human body. They have to be to withstand the wear-andtear of threats from our environment. When you consider our skin is under constant attack, it’s not surprising to find out that our skin cells are one of the few regenerative tissues to express telomerase, the enzyme that rebuilds your telomeres. That fact that our skin cells get some protection from telomere loss is encouraging. But the real question is whether our skin can hold on to this supply of telomerase in the face of environmental threats our ancient ancestors never had to worry about. Back when our ancestors were hunter/gatherers, they faced “organic” threats from their environment like wind, rain and climate changes, as well as cuts and lacerations they suffered during their walks and/or hunts. Today we face “inorganic” threats in the form of chemicals, drugs and other toxins that attack our skin and shorten our telomeres. In spite of our cosmetics, day spas and various treatments, it’s harder to maintain your natural beauty in the modern world than it was centuries ago. And that’s why you must do SOMETHING to stop the loss of telomere length in your skin, hair and nails. If you don’t, you will age faster and accelerate your built-in genetic program that’s designed to make you less attractive as you age. Fortunately, there are simple strategies I give my patients to help protect their telomeres, and in same cases, even lengthen them. And that’s good news, because overexposure to sun light is NOT the only threat to your telomeres.

What Else is Accelerating Loss of Skin Tone? It is worth knowing the factors that can damage your skin causing it to lose its tone and wrinkle earlier than you’d like. Then, you’ll know exactly how you can keep your skin taut and healthy, while still taking advantage of the benefits of sunlight. Aside from overexposure to sunlight, some of the big contributors to damaged skin include:

••Nutritional deficiencies… ••Over consumption of artificial polyunsaturated fats… ••Not getting enough omega-3 fats… ••Exposure to toxins and allergens in our food and water… ••Air pollution… ••Chemical lotions and creams… 8

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••And smoking. Let’s take a closer look at each of these factors.

Sunscreens Don’t Protect Against Photo Aging People slather up with sunscreen and head into intense sun for hours thinking they’re safe from overexposure to the sun. Nothing could be further from the truth. Most sunscreens block UV-B light, the light that causes sunburn. But most do NOT block UV-A light, and it is overexposure to UV-A light which accelerates photo aging of your skin. When you spend a long time in the sun, unprotected from UV-A, this type of radiation can chemically transform and excite certain acids in your skin that then contribute to photo aging pigmentation changes and wrinkles.2 Even worse, many sunscreens still use a compound called PABA. This chemical actually increases photo aging because it inhibits your skin’s ability to repair cellular damage. And there is another reason you should avoid PABA: Many people are allergic and get a rash which looks like a sunburn and further inflames and damages skin. As the Boston University study showed, overexposure to sunlight can also generate free radicals. And that can damage skin cells and reduce the amount of antioxidants present in your skin, specifically vitamin C, vitamin E, and CoQ10.3 The effect of sunlight on the antioxidants present in the skin is important. While moderate sun exposure actually helps to increase antioxidants present in the skin, inappropriate ratios of UV-A radiation or overexposure consumes and lowers antioxidant levels in your skin. This tells us in part how sunlight can damage your skin… and it helps us find ways to counteract the process. Your body uses vitamin C to make collagen. Collagen forms a kind of latticework or scaffolding as the basis of your skin’s structure. When you have healthy collagen, you have taunt, smooth and toned skin. But when any factor damages your skin’s collagen, your skin loses its scaffolding, sags and begins to wrinkle. With a deficiency of vitamin C, this process goes on unchecked without repair. Additionally, vitamin C is critical to many of your skin’s other maintenance and repair processes. When your skin lacks adequate vitamin C, these processes are retarded, slowing repair and contributing to aging of your skin. In other words, if you don’t get enough vitamin C, your skin suffers. But when you get plenty of vitamin C, research shows it does more than just the basics. British researchers examined the skin more than 4,000 American women between the ages of 40 and 74. The women who got more vitamin C showed fewer wrinkles and less dryness.4 As we age, our body’s ability to make collagen decreases. But a team at Duke University discovered that vitamin C reverses this trend. They took skin cells from both newborns and retirees and added vitamin C. When they did, the cells divided

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much faster… even cells from 93-year-olds. The researchers concluded that vitamin C helps your body beat the drop in collagen production.5 Studies also show that vitamin C supports an important immune system function. Your skin is your immune system’s first line of defense. A strong skin barrier keeps attacking microbes out. But it can also help keep healthy moisture in. And a study from The British Journal of Nutrition shows that vitamin C supports a healthier skin barrier.6 So taking vitamin C is a great way to promote healthier, younger-looking skin. But it’s not the only nutrient that can help your skin shrug off UV damage.

Safeguard Your Skin with the Right Fats Omega-3 fatty acids are a group of healthy unsaturated fats. They’re essential for your good health, but your body can’t make them on its own… so you MUST get them from your diet. Omega-3’s are great for your heart, support a strong immune system and may even help with “brain fog” and forgetfulness. But Omega-3’s also support healthy skin. In fact, researchers at Germany’s Heinrich-Heine University say they can be “part of lifelong protection” for your skin.7 More than 15 years of studies from around the world show that the Omega-3 fatty acids found in fish oil support your skin’s UV defenses. One of many studies I’ve found comes from the University of Liverpool. Scientists there found that fish oil, rich in Omega-3’s, “markedly reduced” sunburn response.8 In other words, subjects experienced less skin damage. The kind of damage that makes your skin look older than its years. And fish oil may promote younger looking skin in another way. Most of us think of limp, droopy skin as a sign of age. Skin elasticity, the ability of skin to “snap back” when stretched, is seen as a sign of youth. So a nutrient that could improve your skin elasticity by 10% in just 3 months would be terrific, wouldn’t it? Well that’s exactly what happened when German researchers gave a supplement rich in fish oil to a group of 24 women.9 And these women weren’t teenagers. This study worked with women as old as 60. It appears as though fish oil may work at nearly any age. And there’s good news for rough, scaly skin, too. I’ve come across several studies that show fish oil promotes improvement of dry, scaly skin. After taking fish oil for just a few weeks, the subjects’ skin was smoother and healthier looking… while those taking a placebo showed no improvement at all.10 11 A report in the journal Circulation says it promotes better blood flow in small arteries.12 Since these same

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small arteries nourish your skin, this is another way fish oil supports better skin health, and that youthful appearance you desire. Fish oil is great. But I’ve found another supplement that works remarkably well… whether you take it internally or rub it on your skin. But there’s more to keeping your skin young. I’ve discovered two breakthrough ingredients that help stop the loss of your telomeres, and in some cases even rebuild them.

Rebuild, Repair and Restore Your Skin Cells with this DNA Breakthrough At the beginning of this report I showed how your telomeres are the mechanism by which your skin ages. And now, I’ll show you a way to apply this Nobel Prize-winning breakthrough to skin care. It virtually shuts down the aging of your skin’s DNA. By repairing your skin’s DNA, you can plump up your skin and erase wrinkles, tighten up your sagging jaw line, make your crow’s feet disappear, and banish sun and aging spots. It all begins with an extract that slows the aging process and can extend the lifespan of your skin cells by up to 30%. This amazing extract, called teprenone, delays the shortening of your telomeres and protects your skin’s DNA so you can avoid many of the destructive effects that come with age. That’s why this compound is so exciting. It’s the single best – and easiest – thing you can do for your skin to restore the youthful glow you want the world to see. As you know, each and every day toxins bombard your skin. And when those enzymes disappear it degrades the proteins, antioxidants and oxygen your skin needs to thrive. And it damages your skin’s DNA in the process. Teprenone actively limits, even prevents, oxidative build up in your skin cells and protect your DNA by helping your skin to produce a protein that protects cells against oxidant damage. It also protects the antioxidant activity naturally produced by your skin cells. In clinical trials of women, the results were promising:13

••100% increased the level of moisture in their skin ••100% saw sun spots improve significantly ••Over 90% saw a decrease in redness and pore size ••75% experienced an improvement in skin tone and elasticity ••75% felt roughness and fine lines faded noticeably In a similar study, a clinical trial involving a group of mature women who were suffering from age-related skin problems experienced a 35% increase in skin firmness… a 45% improvement in skin tone… and a restoration of natural skin moisture.14 Teprenone protects your telomeres by activating genes involved in their regulation and elongation. And by protecting your DNA from free radical stress, teprenone supports healthy cell division. It also helps improve the

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metabolism of your skin cells and prevents the loss of cell function by up to 60%.15

Keep the Moisture and Suppleness of Your Youth Squalane is a naturally-occurring lipid in your skin. In fact, it accounts for about 12% of the total fat content in an area of your skin called the sebum.16 You had plenty of squalane during your childhood and into your teen years. The problem is, once you enter your 20s, the amount of squalane in your skin decreases rapidly. More importantly, that loss of squalane opens you up to sunburn and damage caused by the suns UV rays. Squalane has a powerful hydrating action and penetrates into the deepest layer of your skin for the most protection. At the same time, it produces a barrier against water loss, restoring moisture and suppleness to your face, and reducing fine lines and wrinkles. Squalane is easily absorbed and leaves it soft and supple with no greasy residue. It also helps prevent the growth of harmful microorganisms by creating a protective antibacterial coating on your skin.17 Reference: 1 Kosmadaki MG, et al. The role of telomeres in skin aging/photoaging. Micron. 2004;35(3):155-9. 2 Hanson KM and Simon JD. (1998) Epidermal transurocanic acid and the UV-A induced photoaging of the skin. Proc Natl Acad Sci USA 95(18): 10576-78 3 Yamamoto Y. (2001) Role of active oxygen species and antioxidants in photoaging. J Dermatol Sci 27 Suppl 1: S1-4 4 Cosgrove MC, et al. Dietary nutrient intakes and skin-aging appearance among middle-aged American wom- en1,2,3,4. American Journal of Clinical Nutrition, Vol. 86, No. 4, 1225-1231, October 2007. 5 Phillips CL, et al. Effects of Ascorbic Acid on Proliferation and Collagen Synthesis in Relation to the Donor Age of Human Dermal Fibroblasts. Journal of Investigative Dermatology (1994) 103, 228–232. 6 Maggini S, et al. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr. 2007 Oct;98 Suppl 1:S29-35. 7 Sies H and Stahl W. Nutritional protection against skin damage from sunlight. Annu Rev Nutr. 2004;24:173-200. 8 Rhodes LE, et al. Dietary Fish Oil Reduces Basal and Ultraviolet B-Generated PGE2 Levels in Skin and Increases the Threshold to Provocation of Polymorphic Light Eruption. Journal of Investigative Dermatology (1995) 105, 532–535. 9 Segger D, et al. Supplementation with Eskimo Skin Care improves skin elasticity in women. A pilot study. J Der- matolog Treat. 2008;19(5):279-83. 10 Ziboh VA, et al. Effects of Dietary Supplementation of Fish Oil on Neutrophil and Epidermal Fatty Acids. Arch Dermatol 1986;122:1277-1282. 11 S.B.Bittinera,etal.ADouble-Blind,Randomised,Placebo-ControlledTrialOfFishOilInPsoriasis.TheLancet. Volume 331, Issue 8582, 20 February 1988, Pages 378-380. 12 Goode GK, et al. Dietary Supplementation With Marine Fish Oil Improves In Vitro Small Artery Endothelial Function in Hypercholesterolemic Patients. Circulation. 1997;96:2802-2807. 13 Monograph. Renovage study for patent WO 2006/120646. Sederma. 2007 14 Ibid. 15 Ibid. 16 Botek AA, et al. The structure and function of the sebaceous glands. The Biology of the Skin. New York, NY: Parthenon Publishing Group, Inc.;2001:94. 17 Kelly GS. Squalane and its potential clinical uses. Altern Med Rev. 1999 Feb;4(1):29-36.

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